prikaz prve stranice dokumenta Metallothioneins and Megalin Expression Profiling in Premalignant and Malignant Oral Squamous Epithelial Lesions
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Scientific paper - Original scientific paper
Metallothioneins and Megalin Expression Profiling in Premalignant and Malignant Oral Squamous Epithelial Lesions
Cancers, 13 (2021), 18; 4530. https://doi.org/10.3390/cancers13184530
Zulijani, Ana; Dekanić, Andrea; Ćabov, Tomislav; Jakovac, Hrvoje

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Zulijani, A., Dekanić, A., Ćabov, T. & Jakovac, H. (2021). Metallothioneins and Megalin Expression Profiling in Premalignant and Malignant Oral Squamous Epithelial Lesions. Cancers, 13. (18). doi: 10.3390/cancers13184530

Zulijani, Ana, et al. "Metallothioneins and Megalin Expression Profiling in Premalignant and Malignant Oral Squamous Epithelial Lesions." Cancers, vol. 13, no. 18, 2021. https://doi.org/10.3390/cancers13184530

Zulijani, Ana, Andrea Dekanić, Tomislav Ćabov and Hrvoje Jakovac. "Metallothioneins and Megalin Expression Profiling in Premalignant and Malignant Oral Squamous Epithelial Lesions." Cancers 13, no. 18 (2021). https://doi.org/10.3390/cancers13184530

Zulijani, A., et al. (2021) 'Metallothioneins and Megalin Expression Profiling in Premalignant and Malignant Oral Squamous Epithelial Lesions', Cancers, 13(18). doi: 10.3390/cancers13184530

Zulijani A, Dekanić A, Ćabov T, Jakovac H. Metallothioneins and Megalin Expression Profiling in Premalignant and Malignant Oral Squamous Epithelial Lesions. Cancers [Internet]. 2021 September 09 [cited 2024 November 22];13(18). doi: 10.3390/cancers13184530

A. Zulijani, A. Dekanić, T. Ćabov and H. Jakovac, "Metallothioneins and Megalin Expression Profiling in Premalignant and Malignant Oral Squamous Epithelial Lesions", Cancers, vol. 13, no. 18, September 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:882543. [Accessed: 22 November 2024]

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Metadata
Title (english)Metallothioneins and Megalin Expression Profiling in Premalignant and Malignant Oral Squamous Epithelial Lesions
AuthorAna Zulijani
AuthorAndrea Dekanić
AuthorTomislav Ćabov
AuthorHrvoje Jakovac
Author's institution(Clinical Hospital Center Rijeka)
Author's institutionUniversity of Rijeka
(Faculty of Dental Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathophysiology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
This study aimed to assess the relationship and possible interactions between metallothioneins (MTs) and megalin (LRP-2) in different grades of oral squamous cell carcinoma (OSCC) and premalignant lesions of the oral mucosa (oral leukoplakia and oral lichen planus). The study included archived samples of 114 patients and control subjects. Protein expression was examined by immunohistochemistry and immunofluorescence, and staining quantification was performed by ImageJ software. Protein interaction in cancer tissue was tested and visualized by proximity ligation assay. Mann-Whitney and Kruskal-Wallis tests were used to determine the significance of differences between each group, whereas Pearson correlation coefficient was performed to test correlation. Expression of both proteins differed significantly between each group showing the same pattern of gradual increasing from oral lichen planus to poorly differentiated OSCC. Moreover, MTs and megalin were found to co-express and interact in cancer tissue, and their expression positively correlated within the overall study group. Findings of prominent nuclear and chromosomal megalin expression suggest that it undergoes regulated intramembrane proteolysis upon MTs binding, indicating its ability to directly affect gene expression and cellular division in cancer tissue. The data obtained point to the onco-driving potential of MTs-megalin interaction.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCancers
Numberingvol. 13, no. 18, 4530
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers13184530
URN:NBNurn:nbn:hr:184:882543
Publication2021-09-09
Document URLhttps://www.mdpi.com/2072-6694/13/18/4530
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-11-02 08:58:42