prikaz prve stranice dokumenta Natural killer cell effector functions in antiviral defense
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Scientific paper - Review paper
Natural killer cell effector functions in antiviral defense
The FEBS Journal, 289 (2022), 14; 3982-3999. https://doi.org/10.1111/febs.16073
Piersma, Sytse J.; Brizić, Ilija

Cite this document

Piersma, S. J. & Brizić, I. (2022). Natural killer cell effector functions in antiviral defense. The FEBS Journal, 289. (14), 3982-3999. doi: 10.1111/febs.16073

Piersma, Sytse J. and Ilija Brizić. "Natural killer cell effector functions in antiviral defense." The FEBS Journal, vol. 289, no. 14, 2022, pp. 3982-3999. https://doi.org/10.1111/febs.16073

Piersma, Sytse J. and Ilija Brizić. "Natural killer cell effector functions in antiviral defense." The FEBS Journal 289, no. 14 (2022): 3982-3999. https://doi.org/10.1111/febs.16073

Piersma, S. J. and Brizić, I. (2022) 'Natural killer cell effector functions in antiviral defense', The FEBS Journal, 289(14), pp. 3982-3999. doi: 10.1111/febs.16073

Piersma SJ, Brizić I. Natural killer cell effector functions in antiviral defense. The FEBS Journal [Internet]. 2022 [cited 2024 May 06];289(14):3982-3999. doi: 10.1111/febs.16073

S. J. Piersma and I. Brizić, "Natural killer cell effector functions in antiviral defense", The FEBS Journal, vol. 289, no. 14, pp. 3982-3999, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:113346. [Accessed: 06 May 2024]

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Metadata
Title (english)Natural killer cell effector functions in antiviral defense
AuthorSytse J. Piersma
AuthorIlija Brizić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Natural killer (NK) cells are innate lymphoid cells involved in the control of tumors and viral infections. They provide protection by producing cytokines and by directly lysing target cells. Both effector mechanisms have been identified to contribute to viral control, depending on the context of infection. Activation of NK cells depends on the integration of signals received by cytokine receptors and activation and inhibitory receptors recognizing ligands expressed by virus-infected cells. While the control of viral infections by NK cells is well established, the signals perceived by NK cells and how these signals integrate to mediate optimal viral control have been focus of ongoing research. Here, we discuss the current knowledge on NK cell activation and integration of signals that lead to interferon gamma production and cytotoxicity in viral infections. We review NK cell interactions with viruses, with particular focus on murine cytomegalovirus studies, which helped elucidate crucial aspects of antiviral NK cell immunity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleThe FEBS Journal
Numberingvol. 289, no. 14, pp. 3982-3999
p-ISSN1742-464X
e-ISSN1742-4658
DOIhttps://doi.org/10.1111/febs.16073
URN:NBNurn:nbn:hr:184:113346
Publication2022
ProjectNumber: IP-2018-01-4435
Title (croatian): NK stanice u patogenezi kongenitalne infekcije citomegalovirusom
Acronym: NKconCMV
Leader: Ilija Brizić
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/febs.16073
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2021-09-24 16:29:10