master's thesis
Dobno uvjetovane promjene u skeletnoj muskulaturi

Jan Maroević (2016)
Sveučilište u Rijeci
Medicinski fakultet
Katedra za anatomiju
Metadata
TitleDobno uvjetovane promjene u skeletnoj muskulaturi
AuthorJan Maroević
Mentor(s)Marina Nikolić (thesis advisor)
Abstract
U današnjem svijetu sve je veći broj starije populacije koja uz svoje komorbiditete predstavlja veliki javnozdravstveni problem. Kao jedna od vodećih bolesti starije populacije navodi se sarkopenija, koja je bolest u kojoj dolazi do gubitka mišićne mase, a posljedično i gubitka mišićne snage. Sama patogeneza sarkopenije nije poznata sa sigurnošću, no može se povezati sa smanjenjem broja mišićnih vlakana, s povećanom infiltracijom tkiva masnim i vezivnim tkivom, sa starenjem miofibrila, što može rezultirati smanjenjem funkcije pojedinih segmenata unutar miofibrila, sa smanjenjem funkcije mitohondrija, što rezultira neadekvatnim provođenjem procesa odgovornih za pravilnu aktivnost stanica mišićnog sustava. Definitivan lijek za izlječenje sarkopenije ne postoji, no pažnja liječnika i znanstvenika je usmjerena na farmakološko i nefarmakološko liječenje i prevenciju. Nefarmakološki pristup se temelji na dva tipa treninga, aerobnom i otpornom tipu treninga koji na svoj način poboljšavaju mišićnu masu i mišićnu snagu te usporavaju napredovanje sarkopenije. Farmakološko liječenje se temelji na korištenju pripravaka koji su inače u organizmu ključni za nastanak mišićnog tkiva kao što su testosteron, hormon rasta i prekursor spolnih hormona dehidroepiandrosteron. Kao najnovija metoda liječenja navodi se regulacija miostatina.
Keywordsaging Sarcopenia Muscle Skeletal
Committee MembersIvana Marić (committee chairperson)
Tamara Šoić-Vranić (committee member)
Elizabeta Dadić-Hero (committee member)
GranterSveučilište u Rijeci
Medicinski fakultet
Lower level organizational unitsKatedra za anatomiju
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeMedicine
Academic title abbreviationdr. med.
Genremaster's thesis
Language Croatian
Defense date2016-07-15
Parallel abstract (English)
In todays world there is a large number of old people which with their problems represent a major public health issue. Sarcopenia is one of the leading issues of older population in the world. Sarcopenia is a state in which there is a loss of muscle mass and after that the loss of muscle strenght. Patogenesis of sarcopenia isn't clearly defined, but it can be linked with the loss of muscle fibers, with aging of myofibrils which can lead to loss of function of certain segments of the muscle, with reduction of the function of mytochondria which can result in incorrect signals that are responsible for correct function of the muscle cell. Definite cure for sarcopenia does not exist, but the attention of scientists and doctors is focused on farmacological and non-farmacological treatment. Non-farmacological treatment is based on two types of training, aerobic training and resistance type of training. Both are focused on gaining muscle mass and muscle strenght and by that they slow down the progress of sarcopenia. Farmacological treatment is based on usage of preparations that are crucial in our body for making the muscle tissue such as testosteron, growth hormone, dehidroepiandrosterone which is a precursor of sex hormones. As the newest method of treatment is used regulation of myostatine
Parallel keywords (Croatian)starenje sarkopenija skeletna muskulatura
Resource typetext
Access conditionAccess restricted to students and staff of home institution
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:791486
CommitterBosa Licul