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master's thesis
Interakcija kroničnih jetrenih bolesti i upalnih bolesti crijeva
2021. urn:nbn:hr:184:728407
Cvetko, Iva Maja
University of Rijeka
Faculty of Medicine
Department of Internal Medicine

Cite this document

Cvetko, I. M. (2021). Interakcija kroničnih jetrenih bolesti i upalnih bolesti crijeva (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:728407

Cvetko, Iva Maja. "Interakcija kroničnih jetrenih bolesti i upalnih bolesti crijeva." Master's thesis, University of Rijeka, Faculty of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:184:728407

Cvetko, Iva Maja. "Interakcija kroničnih jetrenih bolesti i upalnih bolesti crijeva." Master's thesis, University of Rijeka, Faculty of Medicine, 2021. https://urn.nsk.hr/urn:nbn:hr:184:728407

Cvetko, I. M. (2021). 'Interakcija kroničnih jetrenih bolesti i upalnih bolesti crijeva', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 25 April 2024, https://urn.nsk.hr/urn:nbn:hr:184:728407

Cvetko IM. Interakcija kroničnih jetrenih bolesti i upalnih bolesti crijeva [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2021 [cited 2024 April 25] Available at: https://urn.nsk.hr/urn:nbn:hr:184:728407

I. M. Cvetko, "Interakcija kroničnih jetrenih bolesti i upalnih bolesti crijeva", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:184:728407

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Metadata
TitleInterakcija kroničnih jetrenih bolesti i upalnih bolesti crijeva
Title (english)Interactions between chronic liver diseases and inflammatory bowel disease
AuthorIva Maja Cvetko
MentorSandra Milić (mentor)
Committee memberBrankica Mijandrušić-Sinčić (predsjednik povjerenstva)
Committee memberSrđan Novak (član povjerenstva)
Committee memberDražen Kovač (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Rijeka
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Upalne bolesti crijeva skupina su upalnih bolesti gastrointestinalnog sustava, karakterizirana kroničnim tijekom s brojnim egzacerbacijama i remisijama. Posljednjih godina došlo je do porasta incidencije ovih bolesti u razvijenom svijetu te su postale značajan javnozdravstveni problem. Prezentiraju se širokim spektrom simptoma i znakova te brojnim ekstraintestinalnim manifestacijama, često na hepatobilijarnom sustavu. Kronična jetrena bolest može biti autoimune etiologije, izazvana uporabom lijekova, NAFLD i kolelitijaza. U skupinu autoimunih bolesti jetre spadaju dvije najznačajnije jetrene bolesti: primarni sklerozirajući kolangitis, autoimuni hepatitis te sindrom preklapanja („overlap sindrom“) autoimunog hepatitisa i primarnog sklerozirajućeg kolangitisa. Najčešće se javljaju uz ulcerozni kolitis, a u manjem broju slučajeva njihovoj dijagnozi prethodi dijagnoza Crohnove bolesti. Iako njihova etiologija u povezanosti s upalnim bolestima crijeva još nije do kraja razjašnjena, postoje brojne teorije o etiopatogenezi ovih bolesti. Ovu skupinu bolesti karakterizira progresivan tijek. Budući da je etiopatogeneza još uvijek nerazjašnjena, ne postoji terapija koja bi usporila tijek bolesti i poboljšala prognozu, već je usmjerena na simptomatsku terapiju i liječenje komplikacija. NAFLD jedna je od najčešćih jetrenih manifestacija upalnih bolesti crijeva, koja također može dovesti do visokog stupnja fibroze i ciroze jetre. Lijekovi koji se koriste u terapiji upalnih bolesti crijeva potencijalno su hepatotoksični te mogu izazvati različit stupanj oštećenja jetre.
Abstract (english)
IBD are a group of inflammatory diseases of the gastrointestinal system, characterized by a chronic course with numerous exacerbations and remissions. In the last decade, there has been an increase in the incidence of these diseases in the developed world and they have become a significant public health problem. They are presented with a wide range of symptoms and signs and numerous extraintestinal manifestations, often on the hepatobiliary system. Chronic liver disease can be of autoimmune etiology, caused by the use of drugs, NAFLD, and cholelithiasis. The group of autoimmune liver diseases includes the two most significant liver diseases: PSC, autoimmune hepatitis and overlap syndrome of AIH/PSC. They most often occur with ulcerative colitis, and in a small number of cases, their diagnosis is preceded by a diagnosis of Crohn's disease. Although their etiology in relation to inflammatory bowel disease has not yet been fully elucidated, there are numerous theories about the etiopathogenesis of these diseases. This group of diseases is characterized by a progressive course. Since the etiopathogenesis is still unclear, there is no therapy that would slow the course of the disease and improve the prognosis, but it is focused on symptomatic therapy and treatment of complications. NAFLD is one of the most common liver manifestations of IBD, which can also lead toliver fibrosis and cirrhosis. Drugs used in the treatment of inflammatory bowel disease are potentially hepatotoxic and can cause varying degrees of liver damage.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:728407
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-07-12 17:38:50