Introduction: Depression is frequent psychiatric disorder characterized by the reccurent episodes of depressed mood, but also with different somatic symptoms such as metabolic symtpoms that might result in development of metabolic syndrome. Etiology of depression is not completely known. It is assumed that genes coding for proteins important for regulation and fuction of serotonin (5-HT) system, such as a gene for serotonin transporter (5HTT), and its functional polymorphism 5-HTTLPR (serotonin-transporter-linked polymorphic region), are associated with depression. Aim of study: Study aimed to determine association between 5-HTTLPR and metabolic syndrome and/or components of metabolic syndrome in depressed patients. Namely, we expected that patients with metabolic syndrome will be more frequently carriers of the 5- HTTLPR SS genotype or S allele compared to depressed patients without metabolic syndrome. Subjects and methods: The study included 202 depressed patients with and 204 depresssed patients without metabolic syndrome. Diagnosis of depression was made according to the ICD-10 criteria, and metabolic syndrome according to the criteria of the WHO, and use of routine laboratory and clinical measurements. Genotyping was determined using PCR. Results were analyzed with Kruskal-Wallis ANOVA and Dunn test, Mann Whitney test, Spearman's coefficient of correlation and multiple linear reggression. Results: 5-HTTLPR polymorphism was not significatly associated with metabolic syndrome in depressed patients. However, carriers of the LL genotype had significantly higher diastolic blood pressure and weist circumference than other genotype carriers. Other components of the metabolic syndrome (sistolic blood pressure, triglycerides, glucose, HDL cholesterol concentrations and albumines) were not significantly associated with 5-HTTLPR polymorphism in deppressed patients. Conclusion: 5-HTTLPR polymorphism is not significantly associated with metabolic syndrome in depressed patients. Significant association between 5-HTTLPR and components of metabolic syndrome (diastolic blood pressure and weist circumference) was found, suggesting that LL genotpye of the 5-HTTLPR is a risk genotipe for higher diastolic blood pressure and increased weist circumference. These data suggest that 5-HTTLPR polymorphism has particular role in development of specific components of metabolic syndrome in depressed patients.