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master's thesis
HERPESVIRUSI I IZBJEGAVANJE IMUNOLOŠKOG ODGOVORA DOMAĆINA
2020. urn:nbn:hr:184:436494
Grozaj-Hranić, Romina
University of Rijeka
Faculty of Medicine
Department of Physiology, Immunology and Pathophxsiology

Cite this document

Grozaj Hranić, R. (2020). HERPESVIRUSI I IZBJEGAVANJE IMUNOLOŠKOG ODGOVORA DOMAĆINA (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:436494

Grozaj Hranić, Romina. "HERPESVIRUSI I IZBJEGAVANJE IMUNOLOŠKOG ODGOVORA DOMAĆINA." Master's thesis, University of Rijeka, Faculty of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:184:436494

Grozaj Hranić, Romina. "HERPESVIRUSI I IZBJEGAVANJE IMUNOLOŠKOG ODGOVORA DOMAĆINA." Master's thesis, University of Rijeka, Faculty of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:184:436494

Grozaj Hranić, R. (2020). 'HERPESVIRUSI I IZBJEGAVANJE IMUNOLOŠKOG ODGOVORA DOMAĆINA', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 03 January 2025, https://urn.nsk.hr/urn:nbn:hr:184:436494

Grozaj Hranić R. HERPESVIRUSI I IZBJEGAVANJE IMUNOLOŠKOG ODGOVORA DOMAĆINA [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2020 [cited 2025 January 03] Available at: https://urn.nsk.hr/urn:nbn:hr:184:436494

R. Grozaj Hranić, "HERPESVIRUSI I IZBJEGAVANJE IMUNOLOŠKOG ODGOVORA DOMAĆINA", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:184:436494

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Metadata
TitleHERPESVIRUSI I IZBJEGAVANJE IMUNOLOŠKOG ODGOVORA DOMAĆINA
Title (english)HERPESVIRUSES AND MECHANISMS OF IMMUNOEVASION
AuthorRomina Grozaj-Hranić
MentorHana Mahmutefendić Lučin (mentor)
Committee memberTamara Gulić (predsjednik povjerenstva)
Committee memberMarina Šantić (član povjerenstva)
Committee memberTihana Lenac Roviš (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Rijeka
Defense date and country2020-09-18, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Abstract
Brojna svojstva herpesvirusa doprinose njihovom uspjehu, a najvažnija karakteristika je njihova sposobnost usvajanja dva različita načina životnog ciklusa: latentni i litički ciklus. Herpesvirusi su razvili nekoliko učinkovitih strategija za suzbijanje imunološkog odgovora domaćina. Glavni među njima je inhibicija puta obrade i predočavanja antigena MHC molekulama razreda I, čime se smanjuje učinkovitost predočavanja virusnih epitopa na površini inficirane stanice. U ovom preglednom radu sažeti su mehanizmi koje herpesvirusi koriste za postizanje svojeg cilja, uključujući zaustavljanje sinteze MHC molekula razreda I, blokadu stvaranja peptida posredovanu proteasomomima i prevenciju transporta peptida uz pomoć TAP-a. Nadalje, proteini herpesvirusa mogu zadržati MHC molekule razreda I u endoplazmatskom retikulumu ili usmjeriti njihovu retrogradnu translokaciju iz endoplazmatskog retikuluma u citosol ili endocitozu iz plazmatske membrane uz naknadnu razgradnju. Rezultirajuća nishodna regulacija peptidnih kompleksa MHC I na površini stanice sprječava sposobnost citotoksičnih limfocita T da prepoznaju i eliminiraju stanice zaražene virusom. Također se raspravlja o herpesvirusnim proteinima i mikroRNA koji uzrokuju subverziju odgovora stanica NK. Posljednje, u kroničnim latentnim infekcijama uzrokovanim herpesvirusima, CD4+ limfociti T ne podržavaju samo CD8+ limfocite T i limfocite B u obavljanju njihovih uloga, već i same vrše izravne antivirusne efektorske funkcije koje su ključne za prekid litičke replikacije i uspostavljanje virusne latencije.
Abstract (english)
Numerous properties of herpesviruses contribute to their success and the most important characteristic is their ability to adopt two different ways of life cycle: latent and lytic cycle. Herpesviruses have developed several effective strategies to suppress the host immune response. The major among them is the inhibition of the processing and presentation of antigens by MHC class I molecules, thereby reducing the efficiency of presentation of viral epitopes on the surface of the infected cell. This review summarizes the mechanisms that herpesviruses use to achieve their goal, including inhibition of MHC class I molecules synthesis, proteasome-mediated blockade of peptide production, and prevention of TAP-mediated peptide transport. Furthermore, herpesvirus proteins can retain MHC class I molecules in the endoplasmic reticulum, direct their retrograde translocation from the endoplasmic reticulum or endocytose them from the plasma membrane with subsequent degradation. The resulting down-regulation of MHC class I peptide complexes on the cell surface prevents the ability of cytotoxic T lymphocytes to recognize and eliminate virus-infected cells. Herpesvirus proteins and microRNAs that cause subversion of NK cell responses are also discussed. Lastly, in chronic latent infections caused by herpes viruses, CD4+ T cells not only support CD8+ T cells and B cells in performing their roles but also perform direct antiviral effector functions themselves that are key to disrupting lytic replication and establishing viral latency.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:436494
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-01-11 08:04:21