Access restricted to higher education institution's students and staff
master's thesis
ORAL HERPES SIMPLEX VIRUS INFECTION

Ivana Butković (2016)
Metadata
TitleOralne infekcije uzrokovane herpes simpleks virusom
AuthorIvana Butković
Mentor(s)Miranda Muhvić-Urek (thesis advisor)
Abstract
Oralne i perioralne lezije uzrokovane herpes simpleks virusom (HSV) zahvaćaju 60% do 95% populacije. Većina primarnih HSV infekcija je asimptomatska. Primarni herpetični gingivostomatitis (PHGS) je najčešća manifestacija primarne HSV infekcije. Karakterizira ga pojava oralnih i perioralnih vezikuloulcerativnih lezija i akutni generalizirani marginalni gingivitis. Rekurentne lezije javljaju se najčešće na usnama (rekurentni labijalni herpes), a puno rjeđe intraoralno (rekurentni intraoralni herpes). U imunosuprimiranih pacijenata HSV lezije mogu biti opsežne i dugotrajne, a zbog atipične kliničke slike dijagnoza je često odgođena. Komplikacije tijekom HSV infekcije su rijetke. Povremeno mogu se javiti dehidracija, viremija i visceralna diseminacija virusa, naročito kod djece i imunosuprimiranih pacijenata. Dijagnoza primarnih i rekurentnih infekcija temelji se na kliničkoj slici i dodatni laboratorijski testovi su rijetko potrebni. Većina HSV infekcija je samoograničavajuća i cijeli unutar 2 tjedna. Liječenje PHGS je simptomatsko. Sustavni protuvirusni lijekovi (aciklovir, valaciklovir i famciklovir) koriste se jedino ako se liječenje započne unutar 72 sata od izbijanja lezija u usnoj šupljini. Standardno topikalno liječenje labijalnog herpesa uključuje 5%-tnu aciklovir kremu ili 1%-tnu penciklovir kremu. Intraoralni herpes liječi se simptomatski. Sustavni protuvirusni lijekovi mogu biti učinkoviti u smanjivanju simptoma rekurentnih herpetičnih lezija ili se mogu koristiti za profilaksu rekurentnih HSV infekcija kako bi se smanjila učestalost i težina kliničke slike recidiva.
KeywordsAntiviral therapy Herpes simplex virus Primary herpetic gingivostomatitis Recurrent herpes
Parallel title (English)ORAL HERPES SIMPLEX VIRUS INFECTION
Committee MembersMiranda Muhvić-Urek (committee chairperson)
Sonja Pezelj-Ribarić (committee member)
Danko Bakarčić (committee member)
GranterSveučilište u Rijeci
Medicinski fakultet
Lower level organizational unitsKatedra za oralnu medicinu i parodontologiju
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Dental Medicine
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeDental Medicine
Academic title abbreviationdr. med. dent.
Genremaster's thesis
Language Croatian
Defense date2016-06-30
Parallel abstract (English)
Oral and perioral herpes simplex virus (HSV) infections affect nearly 60% to 95% of human adults. The majority of HSV primary orofacial infections are asymptomatic. Primary herpetic gingivostomatitis (PHGS) is the most common orofacial manifestation of HSV primary infection. It is characterized by oral and/or perioral vesiculoulcerative lesions and acute generalized marginal gingivitis. Recurrent lesions are common on the lips (recurrent herpes labialis) and less common intraorally (recurrent intraoral herpes). In immunosuppressed patients HSV lesions may be large and persistent, diagnosis is often delayed because of the atypical presentation. Complications during HSV infection are rare. Occasionaly dehydration, viremia and visceral dissemination of the virus may occur, primarily in children and immunosuppressed patients. The diagnosis of both primary and recurrent herpetic infections is usually established by clinical presentation of lesions and specific laboratory testing is rarely indicated. Most of HSV infections are self-limiting and lesions heal in less than 2 weeks. The primary treatment for PHGS is supportive. Systemic antiviral drugs (aciclovir, valaciclovir and famciclovir) are used only if treatment is initiated within 72 hours of the outbreak of lesions in the oral cavity. Standard topical therapy for herpes labialis is aciklovir 5% cream and penciclovir 1% cream. Intraoral herpes treatment is symptomatic. Systemic antiviral drugs may be effective in reducing the duration of symptoms of recurrent HSV infection or may be used for prophylaxis of recurrent HSV infections to reduce the frequency and severity of recurrent attack.
Parallel keywords (Croatian)Herpes simpleks virus Primarni herpetični gingivostomatitis Protuvirusno liječenje Rekurentni herpes
Resource typetext
Access conditionAccess restricted to higher education institution's students and staff
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:813955
CommitterBosa Licul