The etiology of the disease is a complex interaction of the environment, pathophysiological factors and genetic predispositions. According to the ESC / EHS guidelines from 2018, arterial hypertension is systolic pressure equal to or above 140 mmHg, diastolic pressure equal to or above 90 mmHg, change must be in two consecutive measurements in the outpatient setting, and the results obtained can be optimal blood pressure, normal blood pressure pressure, highly normal, first, second and third degree arterial hypertension, and isolated systolic hypertension. Pressure can be measured in the outpatient clinic in the presence of a doctor or automated measures without the presence of a doctor, self-examiners outside the office (MATS), and continuous measurement (KMAT). To detect secondary organic damage, perform a neurological examination and determine cognitive status, perform a fundoscopic examination for possible hypertensive retinopathy, auscultation of the carotid artery and heart, palpation of peripheral arteries, comparison of blood pressure in the left and right arm, skin examination, palpation of the kidneys. The patient is required to be physically active, adjusted to the diet, reducing salt and alcohol intake, stopping nicotine consumption. The drug must be well tolerated, economical and easy to apply. For this purpose, we use four groups of drugs: diuretics, calcium antagonists, renin-angiotensin system blockers and beta blockers. Resistant arterial hypertension is hypertension in which satisfactory blood pressure is achieved, despite the use of three full-dose antihypertensives, one of which must be a diuretic, or if it achieves target values only after the administration of four antihypertensive drugs.