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master's thesis
Usporedba biokemijskih bodovnih sustava i tranzijentne elastografije u procjeni fibroze u bolesnika s kroničnim hepatitisom C
2020. urn:nbn:hr:184:821122
Tatalović, Tanja
University of Rijeka
Faculty of Medicine
Department of Internal Medicine

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Tatalović, T. (2020). Usporedba biokemijskih bodovnih sustava i tranzijentne elastografije u procjeni fibroze u bolesnika s kroničnim hepatitisom C (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:821122

Tatalović, Tanja. "Usporedba biokemijskih bodovnih sustava i tranzijentne elastografije u procjeni fibroze u bolesnika s kroničnim hepatitisom C." Master's thesis, University of Rijeka, Faculty of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:184:821122

Tatalović, Tanja. "Usporedba biokemijskih bodovnih sustava i tranzijentne elastografije u procjeni fibroze u bolesnika s kroničnim hepatitisom C." Master's thesis, University of Rijeka, Faculty of Medicine, 2020. https://urn.nsk.hr/urn:nbn:hr:184:821122

Tatalović, T. (2020). 'Usporedba biokemijskih bodovnih sustava i tranzijentne elastografije u procjeni fibroze u bolesnika s kroničnim hepatitisom C', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 06 December 2024, https://urn.nsk.hr/urn:nbn:hr:184:821122

Tatalović T. Usporedba biokemijskih bodovnih sustava i tranzijentne elastografije u procjeni fibroze u bolesnika s kroničnim hepatitisom C [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2020 [cited 2024 December 06] Available at: https://urn.nsk.hr/urn:nbn:hr:184:821122

T. Tatalović, "Usporedba biokemijskih bodovnih sustava i tranzijentne elastografije u procjeni fibroze u bolesnika s kroničnim hepatitisom C", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:184:821122

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TitleUsporedba biokemijskih bodovnih sustava i tranzijentne elastografije u procjeni fibroze u bolesnika s kroničnim hepatitisom C
Title (english)Comparasion of biochemical scores and transient elastography in the assessment of fibrosis in the patients with chronic hepatitis C
AuthorTanja Tatalović
MentorSandra Milić (mentor)
Committee memberGoran Poropat (predsjednik povjerenstva)
Committee memberSrđan Novak (član povjerenstva)
Committee memberDražen Kovač (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Rijeka
Defense date and country2020-07-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Uvod/ cilj: Kronični hepatitis C je upalna bolest jetre uzrokovana HCV infekcijom. Cilj ovoga rada je usporediti APRI i FIB-4 biokemijskih bodovnih sustava u odnosu na tranzijentu elastografiju u procjeni fibroze jetre u pacijenata sa kroničnim hepatitisom C. Ispitanici i metode: U istraživanje smo uključili 33 bolesnika s kroničnim hepatitisom C koji su bili praćeni na Zavodu za gastroenterologiju KBC-a Rijeka u razdoblju od siječnja 2015. godine do prosinca 2019. godine. U pacijenata je učinjena tranzijentna elastografija i izračunati su biokemijski bodovni sustavi, APRI i FIB-4 . Rezultati: Utvrdili smo osjetljivost, specifičnost, prediktivnu vrijednost i točnosti biokemijskih bodovnih sustava, APRI i FIB-4 u odnosu na tranzijentu elastografiju. Dobivena je velika specifičnost APRI (80%) u odnosu na tranzijentnu elastografiju u procjeni fibroze jetre. Utvrđena je i velika specifičnost APRI (92%) u odnosu na tranzijentnu elastografiju u procjeni ciroze jetre. Dobivena je i velika osjetljivost FIB-4 (75%) u odnosu na tranzijentnu elastografiju u procjeni fibroze jetre. Zaključak: S obzirom na visoku specifičnost APRI u pacijenata sa fibrozom i cirozom jetre, možemo zaključiti da APRI dobro korelira s tranzijentnom elastografijom u procjeni zdravih ispitanika. S obzirom na nisku specifičnost i osjetljivost FIB-4 u pacijenata sa cirozom jetre, možemo zaključiti da FIB-4 nije adekvatan za samostalnu procjenu bolesnika sa kroničnim hepatitisom C.
Abstract (english)
Introduction: Chronic hepatitis C is an inflammatory liver disease caused by HCV infection. The aim of this study was to determine the accuracy of APRI and FIB-4 biochemical scores with respect to transient elastography in the assessment of liver fibrosis in patients with chronic hepatitis C. Patients and methods: The study included 33 patients with chronic hepatitis C who were hospitalized at the Department of Gastroenterology, University Hospital Center Rijeka in the period from January 2015 to December 2019. Transient elastography was performed in the patients and biochemical scores, APRI and FIB-4, were calculated. Results: We determined the sensitivity, specificity, predictive value, and accuracy of biochemical scoring systems, APRI, and FIB-4 relative to transient elastography. A high specificity of APRI (80%) was obtained with respect to transient elastography in the assessment of liver fibrosis. A high specificity of APRI (92%) in relation to transient elastography in the assessment of liver cirrhosis was also found. A high sensitivity of FIB-4 (75%) to transient elastography in the assessment of liver fibrosis was also obtained. Conclusion: Given the high specificy of APRI in patients with fibrosis and cirrhosis of the liver, we can conclude that APRI correlates well with transient elastography in the assessment of healthy subjects. Given the low specificity and sensitivity of FIB-4 in patients with liver cirrhosis, we can conclude that FIB-4 is not adequate for self-assessment of patients with chronic hepatitis C.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:821122
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-11-23 10:51:47