master's thesis
Oral lichenoid reaction

Denis Čulina (2014)
Sveučilište u Rijeci
Medicinski fakultet
Katedra za oralnu medicinu i parodontologiju
Metadata
TitleOralna lihenoidna reakcija
AuthorDenis Čulina
Mentor(s)Miranda Muhvić-Urek (thesis advisor)
Abstract
Svrha ovog diplomskog rada bila je pregledom literature i prikazom slučaja proučiti etiološke čimbenike, kliničku sliku, simptome, dijagnozu i liječenje oralne lihenoidne reakcije. Klinički i patohistološki oralna lihenoidna reakcija nalikuje na oralni lihen planus. Glavne razlike u odnosu na oralni lihen su poznati etiološki čimbenici te povlačenje bolesti nakon njihovog ukidanja. Pregledom literature utvrđeno je da su najčešće spominjani etiološki čimbenici sustavni lijekovi, amalgamski ispuni te transplantacijska bolest. Rjeđi čimbenici su kompozitne smole, staklenoionomerni cementi, žvakanje betel oraščića i lišća duhana. Osim žive, koja je glavni metal uzročnik navedeni su bakar, cink i kositar. Klinički pokazatelji kao što su izgled bijelih lezija, erozija i atrofije oralne sluznice, simptomi poput boli i pečenja na vruću i začinjenu hranu ne olakšavaju prepoznavanje bolesti i po njima se oralna lihenoidna reakcija teško može dijagnosticirati. Dijagnostika uključuje uzimanje medicinske anamneze o sustavnim lijekovima te isključivanje sustavnih bolesti. Daljnja dijagnostika uključuje pregled sluznice usne šupljine i inspekciju amalgamskih restauracija. Oralna lihenoidna reakcija uzrokovana amalgamom je posljedica starih, korodiranih i neispoliranih restauracija, crnih površina koje otpuštaju produkte korozija i metalne ione te djeluju toksično i iritiraju sluznicu. Liječenje oralne lihenoidne reakcije ovisi o uzroku. Ako je to amalgamski ispun, potrebno ga je zamijeniti adekvatnim kompozitnim ili keramičkim. Oralnu lihenoidnu reakciju uzrokovanu sustavnim lijekovima treba liječiti zamjenom lijeka uzročnika drugim lijekom ili ukidanjem. Ako zamjena lijeka dovodi do životne ugroženosti, onda oralnu lihenoidnu reakciju liječimo na način kao oralni lihen planus. U radu je također prikazan klinički slučaj bolesnice s oralnom lihenodinom reakcijom uzrokovanom amalgamskim ispunom.
KeywordsDental amalgam Drugs Oral lichenoid reaction
Parallel title (English)Oral lichenoid reaction
Committee MembersMiranda Muhvić-Urek (committee chairperson)
Irena Glažar (committee member)
Alen Braut (committee member)
GranterSveučilište u Rijeci
Medicinski fakultet
Lower level organizational unitsKatedra za oralnu medicinu i parodontologiju
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Dental Medicine
Oral Medicine
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeDental Medicine
Academic title abbreviationdr. med. dent.
Genremaster's thesis
Language Croatian
Defense date2014-09-29
Parallel abstract (English)
The purpose of this graduate thesis is to study the etiology, clinical features, symptoms, diagnosis and therapy of oral lichenoid reaction through a review of literature and a case report. Clinically and histopathologically it resembles oral lichen planus. The main differences to oral lichen are known etiological factors and regression of the disease after their removal. A review of literature on the subject confirmed that the most common factors are systemic medications, amalgam restorations and graft versus host disease. Less common factors include composite resins, glassionomer cement, tobacco and bethel chewing, etc. In addition to mercury, copper, zinc and tin are related to lichenoid reactions as well. Clinical symptoms includ white striae, papulae, plaque, erosions, and atrophy of the oral mucosa. They are not a characteristic appearance of this disease. Accompanying symptoms such as pain, sores and burning sensation caused by hot or spicy food do not make diagnostics any easy. Therefore the diagnostics itself is based on a carefully assembled medical history, especially concerning drugs and must include a detailed inspection of the oral cavity and existing amalgam restorations. Lichenoid reactions are product of old, corroded or unpolished restorations, black surfaces which may release the products of corrosions or metal ions and therefore have a toxic and irritating effect on the mucosa. Treatment of oral lichenoid reaction depends on the etiological factor above all. In case the cause is an amalgam restoration, it is necessary to replace it with composite or ceramic restoration. Lichenoid reactions caused with drugs must be treated by replacing the same drugs with another. In case that is not possible because replacing the same might lead to a life-threatening situation, the reaction should be treated at the same way as oral lichen planus. The thesis also delineates the clinical case of a patient with oral lichenoid reaction caused by an amalgam restoration.
Parallel keywords (Croatian)Dentalni amalgami Lijekovi Oralna lihenoidna reakcija
Resource typetext
Access conditionAccess restricted to students and staff of home institution
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:090909
CommitterBosa Licul