prikaz prve stranice dokumenta Chronic use of statins and acetylsalicylic acid and incidence of post‐endoscopic retrograde cholangiopancreatography acute pancreatitis: A multicenter, prospective, cohort study
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Scientific paper - Original scientific paper
Chronic use of statins and acetylsalicylic acid and incidence of post‐endoscopic retrograde cholangiopancreatography acute pancreatitis: A multicenter, prospective, cohort study
Digestive Endoscopy, (2020); https://doi.org/10.1111/den.13801
Cárdenas‐Jaén, Karina; Archibugi, Livia; Poropat, Goran; Korpela, Taija; Maisonneuve, Patrick; Aparicio, Jose R.; Udd, Marianne; Štimac, Davor; Arcidiacono, Paolo Giorgio; De Pretis, Niccolò; Valente, Roberto; Di Giulio, Emilio; Casellas, Juan A.; Kylänpää, Leena; Hauser, Goran; Mariani, Alberto; Gabbrielli, Armando; Löhr, Matthias; Vanella, Giuseppe; Rainio, Mia; Brozzi, Lorenzo; Arnelo, Urban; Fagerström, Niklas; Capurso, Gabriele; de‐Madaria, Enrique More authors...

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Cárdenas‐Jaén, K., Archibugi, L., Poropat, G., Korpela, T., Maisonneuve, P., Aparicio, J. R. ... de‐Madaria, E. (2020). Chronic use of statins and acetylsalicylic acid and incidence of post‐endoscopic retrograde cholangiopancreatography acute pancreatitis: A multicenter, prospective, cohort study. Digestive Endoscopy. doi: 10.1111/den.13801

Cárdenas‐Jaén, Karina, et al. "Chronic use of statins and acetylsalicylic acid and incidence of post‐endoscopic retrograde cholangiopancreatography acute pancreatitis: A multicenter, prospective, cohort study." Digestive Endoscopy, 2020. https://doi.org/10.1111/den.13801

Cárdenas‐Jaén, Karina, Livia Archibugi, Goran Poropat, Taija Korpela, Patrick Maisonneuve, Jose R. Aparicio, Marianne Udd, et al. "Chronic use of statins and acetylsalicylic acid and incidence of post‐endoscopic retrograde cholangiopancreatography acute pancreatitis: A multicenter, prospective, cohort study." Digestive Endoscopy (2020). https://doi.org/10.1111/den.13801

Cárdenas‐Jaén, K., et al. (2020) 'Chronic use of statins and acetylsalicylic acid and incidence of post‐endoscopic retrograde cholangiopancreatography acute pancreatitis: A multicenter, prospective, cohort study', Digestive Endoscopy. doi: 10.1111/den.13801

Cárdenas‐Jaén K, Archibugi L, Poropat G, Korpela T, Maisonneuve P, Aparicio JR, and sur.. Chronic use of statins and acetylsalicylic acid and incidence of post‐endoscopic retrograde cholangiopancreatography acute pancreatitis: A multicenter, prospective, cohort study. Digestive Endoscopy [Internet]. 2020 September 28 [cited 2025 January 23]. doi: 10.1111/den.13801

K. Cárdenas‐Jaén, et al., "Chronic use of statins and acetylsalicylic acid and incidence of post‐endoscopic retrograde cholangiopancreatography acute pancreatitis: A multicenter, prospective, cohort study", Digestive Endoscopy, September 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:362173. [Accessed: 23 January 2025]

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Metadata
Title (english)Chronic use of statins and acetylsalicylic acid and incidence of post‐endoscopic retrograde cholangiopancreatography acute pancreatitis: A multicenter, prospective, cohort study
AuthorKarina Cárdenas‐Jaén
AuthorLivia Archibugi
AuthorGoran Poropat
AuthorTaija Korpela
AuthorPatrick Maisonneuve
AuthorJose R. Aparicio
AuthorMarianne Udd
AuthorDavor Štimac
AuthorPaolo Giorgio Arcidiacono
AuthorNiccolò De Pretis
AuthorRoberto Valente
AuthorEmilio Di Giulio
AuthorJuan A. Casellas
AuthorLeena Kylänpää
AuthorGoran Hauser
AuthorAlberto Mariani
AuthorArmando Gabbrielli
AuthorMatthias Löhr
AuthorGiuseppe Vanella
AuthorMia Rainio
AuthorLorenzo Brozzi
AuthorUrban Arnelo
AuthorNiklas Fagerström
AuthorGabriele Capurso
AuthorEnrique de‐Madaria
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Objectives Post‐endoscopic retrograde cholangiopancreatography (ERCP) acute pancreatitis (PEP) is a frequent complication of this endoscopic procedure. Chronic statin intake has been linked to lower incidence and severity of acute pancreatitis (AP). Periprocedural rectal administration of non‐steroidal anti‐inflammatory drugs is protective against PEP, but the role of chronic acetylsalicylic acid (ASA) treatment is unclear. We aimed to investigate whether statins and chronic ASA intake are associated with lower risk of PEP. Methods An international, multicenter, prospective cohort study. Consecutive patients undergoing ERCP in seven European centers were included. Patients were followed‐up to detect those with PEP. Multivariate analysis by means of binary logistic regression was performed, and adjusted odds ratios (aORs) were calculated. Results A total of 1150 patients were included, and 70 (6.1%) patients developed PEP. Among statins users, 8.1% developed PEP vs. 5.4% among non‐users (P = 0.09). Multivariate analysis showed no association between statin use and PEP incidence (aOR 1.68 (95% CI 0.94–2.99, P = 0.08)). Statin use had no effect on severity of PEP, being mild in 92.0% of statin users vs. 82.2% in non‐statin users (P = 0.31). Chronic ASA use was not associated with PEP either (aOR 1.02 (95% CI 0.49–2.13), P = 0.96). Abuse of alcohol and previous endoscopic biliary sphincterotomy were protective factors against PEP, while >1 pancreatic guidewire passage, normal bilirubin values, and duration of the procedure >20 minutes, were risk factors. Conclusions The use of statins or ASA is not associated with a lower risk or a milder course of PEP
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusAccepted
Peer reviewPeer review - international
Publication versionPublished version
Journal titleDigestive Endoscopy
p-ISSN0915-5635
e-ISSN1443-1661
DOIhttps://doi.org/10.1111/den.13801
URN:NBNurn:nbn:hr:184:362173
Publication2020-09-28
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/den.13801
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2020-11-03 12:28:54