prikaz prve stranice dokumenta Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer
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Scientific paper - Review paper
Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer
Trends in Cancer, 7 (2021), 1; 57-76. https://doi.org/10.1016/j.trecan.2020.08.003
Bursać, Slađana; Prodan, Ylenia; Pullen, Nick; Bartek, Jiri; Volarević, Siniša

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Bursać, S., Prodan, Y., Pullen, N., Bartek, J. & Volarević, S. (2021). Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer. Trends in Cancer, 7. (1), 57-76. doi: 10.1016/j.trecan.2020.08.003

Bursać, Slađana, et al. "Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer." Trends in Cancer, vol. 7, no. 1, 2021, pp. 57-76. https://doi.org/10.1016/j.trecan.2020.08.003

Bursać, Slađana, Ylenia Prodan, Nick Pullen, Jiri Bartek and Siniša Volarević. "Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer." Trends in Cancer 7, no. 1 (2021): 57-76. https://doi.org/10.1016/j.trecan.2020.08.003

Bursać, S., et al. (2021) 'Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer', Trends in Cancer, 7(1), pp. 57-76. doi: 10.1016/j.trecan.2020.08.003

Bursać S, Prodan Y, Pullen N, Bartek J, Volarević S. Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer. Trends in Cancer [Internet]. 2021 [cited 2024 April 26];7(1):57-76. doi: 10.1016/j.trecan.2020.08.003

S. Bursać, Y. Prodan, N. Pullen, J. Bartek and S. Volarević, "Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer", Trends in Cancer, vol. 7, no. 1, pp. 57-76, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:723535. [Accessed: 26 April 2024]

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Metadata
Title (english)Dysregulated Ribosome Biogenesis Reveals Therapeutic Liabilities in Cancer
AuthorSlađana Bursać
AuthorYlenia Prodan
AuthorNick Pullen
AuthorJiri Bartek
AuthorSiniša Volarević
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Molecular Medicine and Biotechnology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract (english)
Ribosome biogenesis (RiBi) is one of the most complex and energy demandingprocesses in human cells, critical for cell growth and proliferation. Strong causallinks between inherited and acquired impairment in RiBi with cancer pathogene-sis are emerging, pointing to RiBi as an attractive therapeutic target for cancer.Here, we will highlight new knowledge about causes of excessive or impairedRiBi and the impact of these changes on protein synthesis. We will also discusshow new knowledge about secondary consequences of dysregulated RiBi andprotein synthesis, including proteotoxic stress, metabolic alterations, adaptivetranscriptional and translational programs, and the impaired ribosome biogenesischeckpoint (IRBC) provide a foundation for the development of new anticancertherapies
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleTrends in Cancer
Numberingvol. 7, no. 1, pp. 57-76
p-ISSN2405-8033
DOIhttps://doi.org/10.1016/j.trecan.2020.08.003
URN:NBNurn:nbn:hr:184:723535
Publication2021
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S2405803320302351
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2020-09-24 07:24:44