prikaz prve stranice dokumenta Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo
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Scientific paper - Original scientific paper
Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo
Cell Reports, 19 (2017), 11; 2345-2356. https://doi.org/10.1016/j.celrep.2017.05.063
Hirche, Christoph; Frenz, Theresa; Haas, Simon F.; Döring, Marius; Borst, Katharina; Tegtmeyer, Pia-K.; Brizić, Ilija; Jordan, Stefan; Keyser, Kirsten; Chhatbar, Chintan; Pronk, Eline; Lin, Shuiping; Messerle, Martin; Jonjić, Stipan; Falk, Christine S.; Trumpp, Andreas; Essers, Marieke A.G.; Kalinke, Ulrich More authors...

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Hirche, C., Frenz, T., Haas, S. F., Döring, M., Borst, K., Tegtmeyer, P. K. ... Kalinke, U. (2017). Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. Cell Reports, 19. (11), 2345-2356. doi: 10.1016/j.celrep.2017.05.063

Hirche, Christoph, et al. "Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo." Cell Reports, vol. 19, no. 11, 2017, pp. 2345-2356. https://doi.org/10.1016/j.celrep.2017.05.063

Hirche, Christoph, Theresa Frenz, Simon F. Haas, Marius Döring, Katharina Borst, Pia K. Tegtmeyer, Ilija Brizić, et al. "Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo." Cell Reports 19, no. 11 (2017): 2345-2356. https://doi.org/10.1016/j.celrep.2017.05.063

Hirche, C., et al. (2017) 'Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo', Cell Reports, 19(11), pp. 2345-2356. doi: 10.1016/j.celrep.2017.05.063

Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer PK, and sur.. Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. Cell Reports [Internet]. 2017 June [cited 2024 November 22];19(11):2345-2356. doi: 10.1016/j.celrep.2017.05.063

C. Hirche, et al., "Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo", Cell Reports, vol. 19, no. 11, pp. 2345-2356, June 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:463708. [Accessed: 22 November 2024]

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Metadata
Title (english)Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo
AuthorChristoph Hirche
AuthorTheresa Frenz
AuthorSimon F. Haas
AuthorMarius Döring
AuthorKatharina Borst
AuthorPia-K. Tegtmeyer
AuthorIlija Brizić
AuthorStefan Jordan
AuthorKirsten Keyser
AuthorChintan Chhatbar
AuthorEline Pronk
AuthorShuiping Lin
AuthorMartin Messerle
AuthorStipan Jonjić
AuthorChristine S. Falk
AuthorAndreas Trumpp
AuthorMarieke A.G. Essers
AuthorUlrich Kalinke
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Quiescent long-term hematopoietic stem cells (LT-HSCs) are efficiently activated by type I interferon (IFN-I). However, this effect remains poorly investigated in the context of IFN-I-inducing virus infections. Here we report that both vesicular stomatitis virus (VSV) and murine cytomegalovirus (MCMV) infection induce LT-HSC activation that substantially differs from the effects triggered upon injection of synthetic IFN-I-inducing agents. In both infections, inflammatory responses had to exceed local thresholds within the bone marrow to confer LT-HSC cell cycle entry, and IFN-I receptor triggering was not critical for this activation. After resolution of acute MCMV infection, LT-HSCs returned to phenotypic quiescence. However, non-acute MCMV infection induced a sustained inflammatory milieu within the bone marrow that was associated with long-lasting impairment of LT-HSC function. In conclusion, our results show that systemic virus infections fundamentally affect LT-HSCs and that also non-acute inflammatory stimuli in bone marrow donors can affect the reconstitution potential of bone marrow transplants.
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCell Reports
Numberingvol. 19, no. 11, pp. 2345-2356
p-ISSN2211-1247
DOIhttps://doi.org/10.1016/j.celrep.2017.05.063
URN:NBNurn:nbn:hr:184:463708
Publication2017-06
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S2211124717307209
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) icon
Created on2020-04-18 17:30:20