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Scientific paper - Review paper
‘Beauty and the beast’ in infection: How immune–endocrine interactions regulate systemic metabolism in the context of infection
European Journal of Immunology, 49 (2019), 7; 982-995. https://doi.org/10.1002/eji.201847895
Wensveen, Felix M.; Šestan, Marko; Turk Wensveen, Tamara; Polić, Bojan

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Wensveen, F. M., Šestan, M., Turk Wensveen, T. & Polić, B. (2019). ‘Beauty and the beast’ in infection: How immune–endocrine interactions regulate systemic metabolism in the context of infection. European Journal of Immunology, 49. (7), 982-995. doi: 10.1002/eji.201847895

Wensveen, Felix M., et al. "‘Beauty and the beast’ in infection: How immune–endocrine interactions regulate systemic metabolism in the context of infection." European Journal of Immunology, vol. 49, no. 7, 2019, pp. 982-995. https://doi.org/10.1002/eji.201847895

Wensveen, Felix M., Marko Šestan, Tamara Turk Wensveen and Bojan Polić. "‘Beauty and the beast’ in infection: How immune–endocrine interactions regulate systemic metabolism in the context of infection." European Journal of Immunology 49, no. 7 (2019): 982-995. https://doi.org/10.1002/eji.201847895

Wensveen, F. M., et al. (2019) '‘Beauty and the beast’ in infection: How immune–endocrine interactions regulate systemic metabolism in the context of infection', European Journal of Immunology, 49(7), pp. 982-995. doi: 10.1002/eji.201847895

Wensveen FM, Šestan M, Turk Wensveen T, Polić B. ‘Beauty and the beast’ in infection: How immune–endocrine interactions regulate systemic metabolism in the context of infection. European Journal of Immunology [Internet]. 2019 May 27 [cited 2024 November 19];49(7):982-995. doi: 10.1002/eji.201847895

F. M. Wensveen, M. Šestan, T. Turk Wensveen and B. Polić, "‘Beauty and the beast’ in infection: How immune–endocrine interactions regulate systemic metabolism in the context of infection", European Journal of Immunology, vol. 49, no. 7, pp. 982-995, May 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:768921. [Accessed: 19 November 2024]

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Metadata
Title (english)‘Beauty and the beast’ in infection: How immune–endocrine interactions regulate systemic metabolism in the context of infection
AuthorFelix M. Wensveen
AuthorMarko Šestan
AuthorTamara Turk Wensveen
AuthorBojan Polić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The immune and endocrine systems ensure two vital functions in the body. The immune system protects us from lethal pathogens, whereas the endocrine system ensures proper metabolic function of peripheral organs by regulating systemic homeostasis. These two systems were long thought to operate independently. The immune system uses cytokines and immune receptors, whereas the endocrine system uses hormones to regulate metabolism. However, recent findings show that the immune and endocrine systems closely interact, especially regarding regulation of glucose metabolism. In response to pathogen encounter, cytokines modify responsiveness of peripheral organs to endocrine signals, resulting in altered levels of blood hormones such as insulin, which promotes the ability of the body to fight infection. Here we provide an overview of recent literature describing various mechanisms, which the immune system utilizes to modify endocrine regulation of systemic metabolism. Moreover, we will describe how these immune–endocrine interactions derail in the context of obesity. From a clinical perspective we will elaborate how infection and obesity aggravate the development of metabolic diseases such as diabetes mellitus type 2 in humans. In summary, this review provides a comprehensive overview of immune-induced changes in systemic metabolism following infection, with a focus on regulation of glucose metabolism.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Journal of Immunology
Numberingvol. 49, no. 7, pp. 982-995
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201847895
URN:NBNurn:nbn:hr:184:768921
Publication2019-05-27
ProjectNumber: IP-2016-06-8027
Title (croatian): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Acronym: T-MEMORY
Leader: Felix Wensveen
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-2016-06-9306
Title (croatian): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini
Acronym: INFLAMETAB
Leader: Bojan Polić
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201847895
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-02-19 10:52:49