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Scientific paper - Original scientific paper
How alpha beta T cells deal with induced TCR  ablation
Proceedings of the National Academy of Sciences, 98 (2001), 15; 8744-8749. https://doi.org/10.1073/pnas.141218898
Polić, Bojan; Kunkel, D.; Scheffold, A.; Rajewsky, K.

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Polić, B., Kunkel, D., Scheffold, A. & Rajewsky, K. (2001). How alpha beta T cells deal with induced TCR  ablation. Proceedings of the National Academy of Sciences, 98. (15), 8744-8749. doi: 10.1073/pnas.141218898

Polić, Bojan, et al. "How alpha beta T cells deal with induced TCR  ablation." Proceedings of the National Academy of Sciences, vol. 98, no. 15, 2001, pp. 8744-8749. https://doi.org/10.1073/pnas.141218898

Polić, Bojan, D. Kunkel, A. Scheffold and K. Rajewsky. "How alpha beta T cells deal with induced TCR  ablation." Proceedings of the National Academy of Sciences 98, no. 15 (2001): 8744-8749. https://doi.org/10.1073/pnas.141218898

Polić, B., et al. (2001) 'How alpha beta T cells deal with induced TCR  ablation', Proceedings of the National Academy of Sciences, 98(15), pp. 8744-8749. doi: 10.1073/pnas.141218898

Polić B, Kunkel D, Scheffold A, Rajewsky K. How alpha beta T cells deal with induced TCR  ablation. Proceedings of the National Academy of Sciences [Internet]. 2001 July 10 [cited 2024 December 24];98(15):8744-8749. doi: 10.1073/pnas.141218898

B. Polić, D. Kunkel, A. Scheffold and K. Rajewsky, "How alpha beta T cells deal with induced TCR  ablation", Proceedings of the National Academy of Sciences, vol. 98, no. 15, pp. 8744-8749, July 2001. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:477586. [Accessed: 24 December 2024]

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Metadata
Title (english)How alpha beta T cells deal with induced TCR  ablation
AuthorBojan Polić
AuthorD. Kunkel
AuthorA. Scheffold
AuthorK. Rajewsky
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
On deletion of the gene encoding the constant region of the T cell antigen receptor (TCR) a chain in mature T cells by induced Cremediated recombination, the cells lose most of their TCR from the cell surface within 7–10 days, but minute amounts of surfacebound TCR b chains are retained for long periods of time. In a situation in which cellular influx from the thymus is blocked, TCR-deficient naı¨ve T cells decay over time, the decay rates being faster for CD81 cells (t1/2 ' 16 days) than for CD41 cells (t1/2 ' 46 days).TCR1 naı¨vecellsareeithermaintained(CD81)ordecaymore slowly (CD41; t1/2 ' 78 days.) Numbers of TCR-deficient memory T cells decline very slowly (CD81 cells; t1/2 ' 52 days) or not at all (CD41 cells), but at the population level, these cells fail to expand as their TCR1 counterparts do. Together with earlier data on T cell maintenanceinenvironmentslackingappropriatemajorhistocompatibility complex antigens, these data argue against the possibility that spontaneous ligand-independent signaling by the ab TCR contributes significantly to T-cell homeostasis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleProceedings of the National Academy of Sciences
Numberingvol. 98, no. 15, pp. 8744-8749
p-ISSN0027-8424
e-ISSN1091-6490
DOIhttps://doi.org/10.1073/pnas.141218898
URN:NBNurn:nbn:hr:184:477586
Publication2001-07-10
Document URLhttp://www.pnas.org/cgi/doi/10.1073/pnas.141218898
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-02-19 10:42:01