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master's thesis
INVAZIVNE METODE LIJEČENJA KARCINOMA PROSTATE
2019. urn:nbn:hr:184:308379
Počuča, Dino
University of Rijeka
Faculty of Medicine
Department of Urology

Cite this document

Počuča, D. (2019). INVAZIVNE METODE LIJEČENJA KARCINOMA PROSTATE (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:308379

Počuča, Dino. "INVAZIVNE METODE LIJEČENJA KARCINOMA PROSTATE." Master's thesis, University of Rijeka, Faculty of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:184:308379

Počuča, Dino. "INVAZIVNE METODE LIJEČENJA KARCINOMA PROSTATE." Master's thesis, University of Rijeka, Faculty of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:184:308379

Počuča, D. (2019). 'INVAZIVNE METODE LIJEČENJA KARCINOMA PROSTATE', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 05 February 2025, https://urn.nsk.hr/urn:nbn:hr:184:308379

Počuča D. INVAZIVNE METODE LIJEČENJA KARCINOMA PROSTATE [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2019 [cited 2025 February 05] Available at: https://urn.nsk.hr/urn:nbn:hr:184:308379

D. Počuča, "INVAZIVNE METODE LIJEČENJA KARCINOMA PROSTATE", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:184:308379

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Metadata
TitleINVAZIVNE METODE LIJEČENJA KARCINOMA PROSTATE
Title (english)INVASIVE TREATMENT METHODS OF PROSTATE CANCER
AuthorDino Počuča
MentorJosip Španjol (mentor)
MentorRomano Oguić (mentor)
Committee memberStanislav Sotošek (predsjednik povjerenstva)
Committee memberDean Markić (član povjerenstva)
Committee memberAlen Protić (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Rijeka
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract
Prostata je muška spolna žlijezda, smještena u zdjelici između završnog crijeva i mokraćnog mjehura. Njezina uloga je lučenje alkalne mliječne tekućine, bitne za motilitet spermija. Karcinom prostate pripada najčešćim malignim bolestima u muškaraca. Mortalitet je u usporedbi s drugim malignim bolestima nizak, a u prilog tome govori spora progresija bolesti. Postoje mnogi potencijalni rizični faktori za nastanak bolesti, a najistaknutiji je dob muškarca. U svrhu kliničke dijagnostike bolesti koristimo DRP, koncentraciju PSA, TRUZ, a pri određivanju patohistoloških karakteristika koristimo se biopsijom i gradiranjem prema Gleason scoru. Kod dijagnosticirane bolesti TNM klasifikacijom se služimo da bi odredili klinički stadij. U trenutku kad imamo klinički dijagnosticiranu bolest možemo odabrat modalitet liječenja s obzirom na dob muškarca, razinu PSA, GS, TNM i ostale komorbiditete. Liječenje možemo započet aktivnim praćenjem, ukoliko se radi o dobro diferenciranom i ograničenom tumoru te ako je PSA < 10 ng/ mL. Standard kurativnog liječenja čine kirurški zahvati i radioterapija. Kirurški zahvati mogu biti otvoreni, laparoskopski i robotski asistirani. Retropubični i transperinealni su pristupi u otvorenoj kirurgiji. Brahiterapija je invazivna metoda radioterapije u kojoj tumorske stanice pokušavamo uništiti implantiranjem radioaktivnih izotopa u prostatu ili isporučivanjem radijacije putem igala transperinealnim pristupom. Kriokirurgija prostate je metoda u kojoj se koristimo krioprobama da bi isporučili hladnoću koja će uzrokovat nekrozu unutar prostate.
Abstract (english)
Prostate is male reproductive system gland, situated in pelvis between rectum and bladder. Prostate function is secreting alkaline milky substance which helps motility of spermatozoa. Prostate cancer is among most common malignant disease in men. Mortality is low in comparison with other common cancers, which speaks in favour of slow progression of disease. There are many potential risk factors for disease development, most prominent is male age. In diagnostic evaluation digitorectal exam, PSA, transrectal ultrasound are performed. We use biopsy and Gleason grading score for patohistological characteristics. In diagnosis we use TNM classification to determin clinical stage of disease. When we confirm diagnosis of prostate cancer we can choose modality to treat it. Age of patiente, PSA, GS, TNM, comorbidities are considred. Treatment can be started as active surveillance if cancer is well diferentieted, localised and PSA under 10 ng/mL. Standard for curative treatment is consisted of surgery and radiotherapy. Surgery can be performe open, laparascopic or robot-asisted (laparoscopic). In open radical prostatectomy there are 2 ways to approach: retropubic and perineal. Brachytherapy is invasive method of radiotherapy in which tumor cells are destroyed by implanting radioactive isotops into prostate or conducting radioactivity through needles. Cryosurgery is method in which cryoprobes are used to deliver freezing element that will cause necrosis in prostate.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:308379
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-01-22 09:01:02