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master's thesis
UTJECAJ VASKULARNE INVAZIJE I DRUGIH PATOHISTOLOŠKIH PROGNOSTIČKIH PARAMETARA NA POJAVU RECIDIVA I PREŽIVLJAVANJE BOLESNICA S GRANULOZA-STANIČNIM TUMORIMA JAJNIKA
2019. urn:nbn:hr:184:677610
Franin, Ivan
University of Rijeka
Faculty of Medicine
Department of General Pathology and Pathological Anatomy

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Franin, I. (2019). UTJECAJ VASKULARNE INVAZIJE I DRUGIH PATOHISTOLOŠKIH PROGNOSTIČKIH PARAMETARA NA POJAVU RECIDIVA I PREŽIVLJAVANJE BOLESNICA S GRANULOZA-STANIČNIM TUMORIMA JAJNIKA (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:677610

Franin, Ivan. "UTJECAJ VASKULARNE INVAZIJE I DRUGIH PATOHISTOLOŠKIH PROGNOSTIČKIH PARAMETARA NA POJAVU RECIDIVA I PREŽIVLJAVANJE BOLESNICA S GRANULOZA-STANIČNIM TUMORIMA JAJNIKA." Master's thesis, University of Rijeka, Faculty of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:184:677610

Franin, Ivan. "UTJECAJ VASKULARNE INVAZIJE I DRUGIH PATOHISTOLOŠKIH PROGNOSTIČKIH PARAMETARA NA POJAVU RECIDIVA I PREŽIVLJAVANJE BOLESNICA S GRANULOZA-STANIČNIM TUMORIMA JAJNIKA." Master's thesis, University of Rijeka, Faculty of Medicine, 2019. https://urn.nsk.hr/urn:nbn:hr:184:677610

Franin, I. (2019). 'UTJECAJ VASKULARNE INVAZIJE I DRUGIH PATOHISTOLOŠKIH PROGNOSTIČKIH PARAMETARA NA POJAVU RECIDIVA I PREŽIVLJAVANJE BOLESNICA S GRANULOZA-STANIČNIM TUMORIMA JAJNIKA', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 18 December 2024, https://urn.nsk.hr/urn:nbn:hr:184:677610

Franin I. UTJECAJ VASKULARNE INVAZIJE I DRUGIH PATOHISTOLOŠKIH PROGNOSTIČKIH PARAMETARA NA POJAVU RECIDIVA I PREŽIVLJAVANJE BOLESNICA S GRANULOZA-STANIČNIM TUMORIMA JAJNIKA [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2019 [cited 2024 December 18] Available at: https://urn.nsk.hr/urn:nbn:hr:184:677610

I. Franin, "UTJECAJ VASKULARNE INVAZIJE I DRUGIH PATOHISTOLOŠKIH PROGNOSTIČKIH PARAMETARA NA POJAVU RECIDIVA I PREŽIVLJAVANJE BOLESNICA S GRANULOZA-STANIČNIM TUMORIMA JAJNIKA", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:184:677610

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TitleUTJECAJ VASKULARNE INVAZIJE I DRUGIH PATOHISTOLOŠKIH PROGNOSTIČKIH PARAMETARA NA POJAVU RECIDIVA I PREŽIVLJAVANJE BOLESNICA S GRANULOZA-STANIČNIM TUMORIMA JAJNIKA
AuthorIvan Franin
MentorEmina Babarović (mentor)
Committee memberElvira Mustać (predsjednik povjerenstva)
Committee memberIta Hadžisejdić (član povjerenstva)
Committee memberAleks Finderle (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Rijeka
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract
Granuloza-stanični tumori jajnika predstavljaju 2%-5% svih tumora jajnika. Cilj ovog istraživanja bio je analizirati vaskularnu invaziju i ostale patohistološke parametre i njihov utjecaj na pojavu recidiva, ukupno preživljavanje i preživljavanje bez povrata bolesti kod bolesnica s granuloza-staničnim tumorima jajnika.Uzorci tumora analizirani u ovom retrospektivnom istraživanju dobiveni su od ukupno 43 bolesnice s dijagnozom granulozastaničnog tumora jajnika, kirurški liječenih na Odjelu za ginekologiju Kliničkog bolničkog centra Rijeka, prikupljeni između 1994. i 2012. godine.Patohistološki podaci prikupljeni su iz računalne baze podataka Zavoda za patologiju i patološku anatomiju Medicinskog fakulteta u Rijeci. Imunohistokemijsko bojanje s anti-CD34 protutijelom upotrijebljeno je da se istaknu endotelne stanice krvnih žila, a preparati su pregledani na prisutnost ili odsutnost vaskularne invazije.Prosječna dob prilikom postavljanja dijagnoze bila je 53 godine s rasponom od 17 do 84 godina. Većina bolesnica, 32 (74%) su bili u FIGO stadiju IA, 5 (11%) u stadiju IC1, 2 (5%) u stadiju IC2, 2 (5%) u stadiju IC3 i 2 (5%) u stadiju III. Tijekom perioda praćenja (medijan 96 mjeseci, raspon 7-276), recidiv se pojavio u 7 bolesnica (17%), a zabilježeno je 4 smrti. U multivarijatnoj analizi prediktori recidiva bili su vaskularna invazija (p = 0.042, OR = 14.03) i krvarenje (p = 0.013, OR = 24.14), dok se FIGO stadij pokazao kao nezavisni prediktor preživljavanja bez povrata bolesti kod bolesnica s granuloza-staničnim tumorom jajnika (p = 0.004, HR = 25.95).
Abstract (english)
Granulosa cell tumors represent 2% -5% of all ovarian tumors. The aim of this study was to analyze vascular space invasion and other pathohistological parameters and their impact on recurrent disease, overall survival and disease-free survival in patients with granulosa celltumors of the ovary. Tumor samples analyzed in this retrospective study were obtained from a total of 43 patients diagnosed with granulosa cell tumors of the ovary, surgically treated at the Department of Gynecology of the Rijeka Clinical Hospital Center, collected between 1994 and 2012. Patohistological data were collected from the computer database of the Department of Pathology and Pathological Anatomy of the Faculty of Medicine in Rijeka. Immunohistochemical staining with anti-CD34 antibody was used to highlight endothelial blood vessel cells, and slides were screened for the presence or absence of vascular invasion. The average age at diagnosis was 53 years with a range of 17 to 84 years. The majority of patients, 32 (74%), were in FIGO stage IA, 5 (11%) in stage IC1, 2 (5%) in IC2, 2 (5%) in stage IC3 and 2 (5%) in stage III . During the follow-up period (median 96 months, range 7- 276), recurrence occurred in 7 patients (17%), and 4 deaths were recorded. In the multivariate analysis, independent predictors of recurrence were vascular invasion (p = 0.042, OR = 14.03) and tumor bleeding (p = 0.013, OR = 24.14), while FIGO stage came out as an independent predictor of disease-free survival in patients with granulosa cell tumors of the ovary (p = 0.004, HR = 25.95).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:677610
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-12-04 13:49:50