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Scientific paper - Original scientific paper
Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes
SAGE Open Medicine, 7 (2019); 1-8. https://doi.org/10.1177/2050312119865137
Dević Pavlić, Sanja; Tramišak Milaković, Tamara; Panić Horvat, Linda; Čavlović, Kristina; Vlašić, Hrvoje; Manestar, Miljenko; Smiljan Severinski, Neda; Radojčić Badovinac, Anđelka

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Dević Pavlić, S., Tramišak Milaković, T., Panić Horvat, L., Čavlović, K., Vlašić, H., Manestar, M. ... Radojčić Badovinac, A. (2019). Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes. SAGE Open Medicine, 7., 1-8. doi: 10.1177/2050312119865137

Dević Pavlić, Sanja, et al. "Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes." SAGE Open Medicine, vol. 7, 2019, pp. 1-8. https://doi.org/10.1177/2050312119865137

Dević Pavlić, Sanja, Tamara Tramišak Milaković, Linda Panić Horvat, Kristina Čavlović, Hrvoje Vlašić, Miljenko Manestar, Neda Smiljan Severinski and Anđelka Radojčić Badovinac. "Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes." SAGE Open Medicine 7 (2019): 1-8. https://doi.org/10.1177/2050312119865137

Dević Pavlić, S., et al. (2019) 'Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes', SAGE Open Medicine, 7, pp. 1-8. doi: 10.1177/2050312119865137

Dević Pavlić S, Tramišak Milaković T, Panić Horvat L, Čavlović K, Vlašić H, Manestar M, and sur.. Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes. SAGE Open Medicine [Internet]. 2019 July 16 [cited 2024 December 04];7:1-8. doi: 10.1177/2050312119865137

S. Dević Pavlić, et al., "Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes", SAGE Open Medicine, vol. 7, pp. 1-8, July 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:294760. [Accessed: 04 December 2024]

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Metadata
Title (english)Genes for anti-Müllerian hormone and androgen receptor are underexpressed in human cumulus cells surrounding morphologically highly graded oocytes
AuthorSanja Dević Pavlić
AuthorTamara Tramišak Milaković
AuthorLinda Panić Horvat
AuthorKristina Čavlović
AuthorHrvoje Vlašić
AuthorMiljenko Manestar
AuthorNeda Smiljan Severinski
AuthorAnđelka Radojčić Badovinac
Author's institutionUniversity of Rijeka
(Faculty of Biotechnology and Drug Development)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Interdisciplinary Technical Sciences
Abstract (english)
Objectives: The aim of this study was to investigate the expression of genes crucial for the quality of the oocyte and whether expression levels of these genes in cumulus cells can be biological markers for the quality of the oocyte, zygote or embryo, or even for achievement of pregnancy after the assisted reproductive technology procedure. We examined the expression profile of the anti-Müllerian hormone (AMH) gene and its respective receptors: anti-Müllerian hormone receptor type 2 (AMHR2), follicle-stimulating hormone receptor (FSHR) and androgen receptor (AR) in cumulus cells (CCs) surrounding the oocyte, as well as AMH concentrations in follicular fluid of the associated follicle. The obtained gene expression levels were correlated with the morphological quality of the associated oocyte, zygote and embryo as well as with assisted reproductive technology outcome following the intracytoplasmic sperm injection procedure. Results: The results yielded suggest a relationship between AMH, AR and oocyte morphology: AMH and AR gene expression levels in CCs surrounding morphologically optimal oocytes were significantly lower than in CCs surrounding oocytes with suboptimal morphology (p = 0.011 and p = 0.008, respectively). Statistically significant positive correlation was found between mRNA expression levels of AMH and FSHR (p < 0.001), AMH and AR (p = 0.001), AMHR2 and FSHR (p < 0.001), AMHR2 and AR (p < 0.001), as well as between FSHR and AR (p < 0.001). Conclusion: Assessed results point to AMH and AR relation with oocyte maturity, but not with its fertilization potential, or with embryo quality.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleSAGE Open Medicine
Numberingvol. 7, pp. 1-8
e-ISSN2050-3121
DOIhttps://doi.org/10.1177/2050312119865137
URN:NBNurn:nbn:hr:184:294760
Publication2019-07-16
Document URLhttp://journals.sagepub.com/doi/10.1177/2050312119865137
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2019-10-11 09:26:55