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Scientific paper - Original scientific paper
Upalna bolest crijeva i bubreg – postoji li povezanost?
Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, 70 (2016), Suplement 2; 19-25. urn:nbn:hr:184:231464
Mikolašević, Ivana; Milić, Sandra; Mijandrušić-Sinčić, Brankica; Lukenda Žanko, Vesna; Jelić Pranjić, Ita; Mavrinac, Vojko; Krznarić-Zrnić, Irena; Rački, Sanjin; Štimac, Davor; Orlić, Lidija

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Mikolašević, I., Milić, S., Mijandrušić Sinčić, B., Lukenda Žanko, V., Jelić Pranjić, I., Mavrinac, V. ... Orlić, L. (2016). Upalna bolest crijeva i bubreg – postoji li povezanost?. Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, 70. (Suplement 2), 19-25. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:231464

Mikolašević, Ivana, et al. "Upalna bolest crijeva i bubreg – postoji li povezanost?." Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, vol. 70, no. Suplement 2, 2016, pp. 19-25. https://urn.nsk.hr/urn:nbn:hr:184:231464

Mikolašević, Ivana, Sandra Milić, Brankica Mijandrušić Sinčić, Vesna Lukenda Žanko, Ita Jelić Pranjić, Vojko Mavrinac, Irena Krznarić Zrnić, Sanjin Rački, Davor Štimac and Lidija Orlić. "Upalna bolest crijeva i bubreg – postoji li povezanost?." Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske 70, no. Suplement 2 (2016): 19-25. https://urn.nsk.hr/urn:nbn:hr:184:231464

Mikolašević, I., et al. (2016) 'Upalna bolest crijeva i bubreg – postoji li povezanost?', Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, 70(Suplement 2), pp. 19-25. Available at: https://urn.nsk.hr/urn:nbn:hr:184:231464 (Accessed 12 November 2024)

Mikolašević I, Milić S, Mijandrušić Sinčić B, Lukenda Žanko V, Jelić Pranjić I, Mavrinac V, and sur.. Upalna bolest crijeva i bubreg – postoji li povezanost?. Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske [Internet]. 2016 [cited 2024 November 12];70(Suplement 2):19-25. Available at: https://urn.nsk.hr/urn:nbn:hr:184:231464

I. Mikolašević, et al., "Upalna bolest crijeva i bubreg – postoji li povezanost?", Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, vol. 70, no. Suplement 2, pp. 19-25, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:231464. [Accessed: 12 November 2024]

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Metadata
Title (croatian)Upalna bolest crijeva i bubreg – postoji li povezanost?
Title (english)INFLAMMATORY BOWEL DISEASE AND KIDNEY– IS THERE A CONNECTION?
AuthorIvana Mikolašević
AuthorSandra Milić
AuthorBrankica Mijandrušić-Sinčić
AuthorVesna Lukenda Žanko
AuthorIta Jelić Pranjić
AuthorVojko Mavrinac
AuthorIrena Krznarić-Zrnić
AuthorSanjin Rački
AuthorDavor Štimac
AuthorLidija Orlić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (croatian)
Cilj ove studije bio je ispitati imaju li bolesnici s upalnom bolesti crijeva u nekoj mjeri promjene na bubregu. Štoviše, ispitivali smo odnosi li se ta povezanost na aktivnu bolest crijeva. U ovoj presječnoj studiji okupili smo od rujna 2012. do rujna 2013. godine 50 bolesnika srednje dobi od 47,1±16,5 godina s dijagnozom upalne bolesti crijeva postavljenom na osnovi anamneze, endoskopskih, histoloških i radioloških nalaza. Aktivnost bolesti procjenjivali smo indeksom aktivnosti ulceroznog kolitisa (UC activity index, UCAI) i indeksom za Crohnovu bolest (Crohn’s disease index, CDAI). Bilo je 38% bolesnika s ulcertivnim kolitisom (UK) i 62% bolesnika s Crohnovom bolešću (CB). Učestalost abnormalne albuminurije bila je 21,1% u bolesnika s UK i 29% u onih s CB. Nađena je visoka negativna korelacija između trajanja bolesti crijeva i 24-h albuminurije u bolesnika s UK, kao i visoka korelacija između odnosa albumin-kreatinin (ACR) i zbira UCAI u bolesnika s UK, ali te korelacije nisu bile statistički značajne, vjerojatno zbog malog broja bolesnika s UK. S druge strane, procijenjena stopa glomerularne filtracije (estimated glomerular filtration rate, eGFR) pokazala negativnu korelaciju s aktivnošću bolesti u bolesnika s CB (r=-0,569; p=0,05), dok nije bilo statistički značajne korelacije između UK i eGFR (r=0,343; p=NS). Zaključujemo da je abnormalna albuminurija dosta česta u bolesnika s upalnom bolesti crijeva. Čini se da bolesnici s tom bolešću imaju do neke mjere oštećenje glomerula, pretežito oni s CB. Da se istraži ta povezanost potrebne su zajedničke prospektivne studije gastroenterologa i nefrologa.
Abstract (english)
The aim of the present study was to investigate whether patients with inflammatory bowel disease (IBD) have some degree of renal involvement. Furthermore, we investigated whether this connection is related to active bowel disease. In this cross-sectional study, 50 patients diagnosed with IBD, mean age 47.1±16.5 years, were recruited from September 2012 to September 2013. The diagnosis of IBD was based on clinical history, endoscopic, histological and radiological findings. Disease activity was assessed using the UC activity indeks (UCAI) for ulcerative colitis (UC) and Crohn’s disease activity index (CDAI) for Crohn’s disease (CD). There were 38% of UC patients and 62% of CD patients. The prevalence of abnormal albuminuria in UC and CD patients was 21.1% and 29%, respectively. There was a high negative correlation between duration of bowel disease and 24-h albuminuria in UC patients, as well as a high correlation between albumin-creatinine ratio (ACR) and UCAI score in UC patients, but these correlations were not statistically significant, probably due to the small number of UC patients. On the other hand, estimated glomerular filtration rate (eGFR) showed negative correlation with disease activity in CD patients (r=-0.569; p=0.05), while there was no statistically significant correlation between active UC and eGFR (r=0.343; p=NS). In conclusion, abnormal albuminuria is quite frequent in patients with IBD. It seems that patients with IBD have some degree of glomerular damage, mainly those with CD. Collaborative, prospective studies conducted by gastroenterologists and nephrologists are needed to investigate this association.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske
Numberingvol. 70, no. Suplement 2, pp. 19-25
p-ISSN1330-0164
e-ISSN1848-8897
URN:NBNurn:nbn:hr:184:231464
Publication2016
Document URLhttps://hrcak.srce.hr/180118
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2019-04-15 19:22:22