prikaz prve stranice dokumenta Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1
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Scientific paper - Original scientific paper
Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1
Cell Reports, 26 (2019), 9; 2394-2406.e5. https://doi.org/10.1016/j.celrep.2019.02.017
Gawish, Riem; Bulat, Tanja; Biaggio, Mario; Lassnig, Caroline; Bago-Horvath, Zsuzsanna; Macho-Maschler, Sabine; Poelzl, Andrea; Simonović, Natalija; Prchal-Murphy, Michaela; Rom, Rita; Amenitsch, Lena; Ferrarese, Luca; Kornhoff, Juliana; Lederer, Therese; Svinka, Jasmin; Eferl, Robert; Bosmann, Markus; Kalinke, Ulrich; Stoiber, Dagmar; Sexl, Veronika; Krmpotić, Astrid; Jonjić, Stipan; Müller, Mathias; Strobl, Birgit More authors...

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Gawish, R., Bulat, T., Biaggio, M., Lassnig, C., Bago Horvath, Z., Macho Maschler, S. ... Strobl, B. (2019). Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1. Cell Reports, 26. (9), 2394-2406.e5. doi: 10.1016/j.celrep.2019.02.017

Gawish, Riem, et al. "Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1." Cell Reports, vol. 26, no. 9, 2019, pp. 2394-2406.e5. https://doi.org/10.1016/j.celrep.2019.02.017

Gawish, Riem, Tanja Bulat, Mario Biaggio, Caroline Lassnig, Zsuzsanna Bago Horvath, Sabine Macho Maschler, Andrea Poelzl, et al. "Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1." Cell Reports 26, no. 9 (2019): 2394-2406.e5. https://doi.org/10.1016/j.celrep.2019.02.017

Gawish, R., et al. (2019) 'Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1', Cell Reports, 26(9), pp. 2394-2406.e5. doi: 10.1016/j.celrep.2019.02.017

Gawish R, Bulat T, Biaggio M, Lassnig C, Bago Horvath Z, Macho Maschler S, and sur.. Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1. Cell Reports [Internet]. 2019 February [cited 2024 December 27];26(9):2394-2406.e5. doi: 10.1016/j.celrep.2019.02.017

R. Gawish, et al., "Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1", Cell Reports, vol. 26, no. 9, pp. 2394-2406.e5, February 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:558534. [Accessed: 27 December 2024]

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Metadata
Title (english)Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1
AuthorRiem Gawish
AuthorTanja Bulat
AuthorMario Biaggio
AuthorCaroline Lassnig
AuthorZsuzsanna Bago-Horvath
AuthorSabine Macho-Maschler
AuthorAndrea Poelzl
AuthorNatalija Simonović
AuthorMichaela Prchal-Murphy
AuthorRita Rom
AuthorLena Amenitsch
AuthorLuca Ferrarese
AuthorJuliana Kornhoff
AuthorTherese Lederer
AuthorJasmin Svinka
AuthorRobert Eferl
AuthorMarkus Bosmann
AuthorUlrich Kalinke
AuthorDagmar Stoiber
AuthorVeronika Sexl
AuthorAstrid Krmpotić
AuthorStipan Jonjić
AuthorMathias Müller
AuthorBirgit Strobl
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Cytomegalovirus (CMV) has a high prevalence worldwide, is often fatal for immunocompromised patients, and causes bone marrow suppression. Deficiency of signal transducer and activator of transcription 1 (STAT1) results in severely impaired antiviral immunity. We have used cell-type restricted deletion of Stat1 to determine the importance of myeloid cell activity for the defense against murine CMV (MCMV). We show that myeloid STAT1 limits MCMV burden and infection-associated pathology in the spleen but does not affect ultimate clearance of infection. Unexpectedly, we found an essential role of myeloid STAT1 in the induction of extramedullary hematopoiesis (EMH). The EMH-promoting function of STAT1 was not restricted to MCMV infection but was also observed during CpG oligodeoxynucleotide-induced sterile inflammation. Collectively, we provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCell Reports
Numberingvol. 26, no. 9, pp. 2394-2406.e5
p-ISSN2211-1247
DOIhttps://doi.org/10.1016/j.celrep.2019.02.017
URN:NBNurn:nbn:hr:184:558534
Publication2019-02
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S2211124719301792
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2019-03-05 20:35:27