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Scientific paper - Original scientific paper
Uloga 99mTc-MIBI-ja u dijagnostici afunkcionalnih čvorova štitne žlijezde
Medicina Fluminensis : Medicina Fluminensis, 55 (2019), 1; 59-64. https://doi.org/10.21860/medflum2019_216314
Fischer, Leo; Ilić Tomaš, Maja; Bogović Crnčić, Tatjana; Girotto, Neva; Pribanić, Ivan; Grbac-Ivanković, Svjetlana

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Fischer, L., Ilić Tomaš, M., Bogović Crnčić, T., Girotto, N., Pribanić, I. & Grbac Ivanković, S. (2019). Uloga 99mTc-MIBI-ja u dijagnostici afunkcionalnih čvorova štitne žlijezde. Medicina Fluminensis : Medicina Fluminensis, 55. (1), 59-64. doi: 10.21860/medflum2019_216314

Fischer, Leo, et al. "Uloga 99mTc-MIBI-ja u dijagnostici afunkcionalnih čvorova štitne žlijezde." Medicina Fluminensis : Medicina Fluminensis, vol. 55, no. 1, 2019, pp. 59-64. https://doi.org/10.21860/medflum2019_216314

Fischer, Leo, Maja Ilić Tomaš, Tatjana Bogović Crnčić, Neva Girotto, Ivan Pribanić and Svjetlana Grbac Ivanković. "Uloga 99mTc-MIBI-ja u dijagnostici afunkcionalnih čvorova štitne žlijezde." Medicina Fluminensis : Medicina Fluminensis 55, no. 1 (2019): 59-64. https://doi.org/10.21860/medflum2019_216314

Fischer, L., et al. (2019) 'Uloga 99mTc-MIBI-ja u dijagnostici afunkcionalnih čvorova štitne žlijezde', Medicina Fluminensis : Medicina Fluminensis, 55(1), pp. 59-64. doi: 10.21860/medflum2019_216314

Fischer L, Ilić Tomaš M, Bogović Crnčić T, Girotto N, Pribanić I, Grbac Ivanković S. Uloga 99mTc-MIBI-ja u dijagnostici afunkcionalnih čvorova štitne žlijezde. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2019 March 01 [cited 2024 April 17];55(1):59-64. doi: 10.21860/medflum2019_216314

L. Fischer, M. Ilić Tomaš, T. Bogović Crnčić, N. Girotto, I. Pribanić and S. Grbac Ivanković, "Uloga 99mTc-MIBI-ja u dijagnostici afunkcionalnih čvorova štitne žlijezde", Medicina Fluminensis : Medicina Fluminensis, vol. 55, no. 1, pp. 59-64, March 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:007755. [Accessed: 17 April 2024]

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Title (croatian)Uloga 99mTc-MIBI-ja u dijagnostici afunkcionalnih čvorova štitne žlijezde
Title (english)The role of 99mTc-MIBI in the evaluation of non-functional thyroid gland nodules
AuthorLeo Fischer
AuthorMaja Ilić Tomaš
AuthorTatjana Bogović Crnčić
AuthorNeva Girotto
AuthorIvan Pribanić
AuthorSvjetlana Grbac-Ivanković
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Nuclear Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Nuclear Medicine
Abstract (croatian)
Cilj: Cilj studije je prikazati ulogu oslikavanja 99mTc metoksiizobutilizonitrilom (99mTc-MIBI) pomoću planarnog oslikavanja i jednofotonske emisijske tomografije “niskodoznom” kompjutoriziranom tomografijom (engl. single photon emission computerized tomography – computerized tomography, SPECT-CT), u obradi čvorova štitne žlijezde koji su afunkcionalni na oslikavanju 99mTc-pertehnetatom i potvrđeni ultrazvučnim pregledom. Ispitanici i metode: Retrospektivno su pregledani nalazi pacijenata kojima je učinjeno oslikavanje štitne žlijezde 99mTc-MIBI-jem i citološka punkcija u periodu od 2008. do 2018., te su uspoređeni s patohistološkim nalazom (engl. pathohistological diagnosis, PHD). Studije su snimljene gama-kamerom s kolimatorom visoke rezolucije na dva načina: planarno i tomografski (SPECT-CT). Rezultati citološke punkcije klasificirani su po Bethesda klasifikaciji dok su PHD rezultati klasificirani kao benigni ili maligni. Rezultati: U razdoblju od 2008. do 2018. snimljena je 271 studija štitne žlijezde 99mTc-MIBI-jem. Kod 42 pacijenta bili su zadovoljeni svi uključni kriteriji. Od ta 42 pacijenta s PHD nalazom 28 ih je bilo suspektno, odnosno čvor se na oslikavanju 99mTc-MIBI-jem prikazao kao hipermetabolički. Negativna prediktivna vrijednost metode iznosi 78,6 % (NPV = 11/(3+11) = 0,786), a pozitivna prediktivna vrijednost 18 % (PPV = 5/(5+23) = 0,179). Zaključak: S obzirom na visoku negativnu prediktivnu vrijednost, slikovna dijagnostika 99mTc-MIBI-jem može se preporučiti kao komplementarna metoda citološkoj punkciji u obradi čvorova u štitnoj žlijezdi.
Abstract (english)
Aim: The objective of the study is to show the role of 99mTc methoxyisobutylisonitrile (99mTc-MIBI) with planar imaging and single photon emission tomography with “low dose” CT (SPECT-CT) in a work up of non-functioning thyroid nodules on imaging with 99mTc- pertechnetate, which were confirmed by ultrasound examination. Patients and methods: Patients who underwent thyroid imaging with 99mTc-MIBI in the period from 2008 to 2018 were reviewed. The findings were compared with PHD results. The imaging was performed on gamma camera with high resolution collimator as planar scintigraphy and SPECT-CT. The results of fine needle aspiration biopsy were classified by the Bethesda classification, while PHD results were classified, as benign or malignant. Results: In the period from 2008-2018, 271 thyroid imaging with 99mTc- MIBI were performed. In 42 patients all-inclusive criteria were met.Out of those 42 patients, 28 of the PHD findings were concordant with the imaging, i.e. a node was presented as hypermetabolic. The calculated negative predictive value of the procedure is 78.6% (NPV = 11/ (3+11) = 0,786), and positive predictive value 18% (PPV = 5/ (5+23) = 0.179). Conclusion: Given the high negative predictive value, obtained from our results, 99mTc -MIBI imaging may be recommended as a complementary diagnostic method to fine-needle aspiration (FNA) in work up of thyroid nodules.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 55, no. 1, pp. 59-64
p-ISSN1847-6864
e-ISSN1848-1868
DOIhttps://doi.org/10.21860/medflum2019_216314
URN:NBNurn:nbn:hr:184:007755
Publication2019-03-01
Document URLhttps://hrcak.srce.hr/216314
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 3.0 Unported (CC BY 3.0) icon
Created on2019-03-01 10:55:44