prikaz prve stranice dokumenta Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack
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Scientific paper - Original scientific paper
Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack
Immunity, 42 (2015), 2; 344-355. https://doi.org/10.1016/j.immuni.2015.01.010
Gur, Chamutal; Ibrahim, Yara; Isaacson, Batya; Yamin, Rachel; Abed, Jawad; Gamliel, Moriya; Enk, Jonatan; Bar-On, Yotam; Stanietsky-Kaynan, Noah; Coppenhagen-Glazer, Shunit; Shussman, Noam; Almogy, Gideon; Cuapio, Angelica; Hofer, Erhard; Mevorach, Dror; Tabib, Adi; Ortenberg, Rona; Markel, Gal; Miklić, Karmela; Jonjić, Stipan; Brennan, Caitlin A.; Garrett, Wendy S.; Bachrach, Gilad; Mandelboim, Ofer More authors...

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Gur, C., Ibrahim, Y., Isaacson, B., Yamin, R., Abed, J., Gamliel, M. ... Mandelboim, O. (2015). Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack. Immunity, 42. (2), 344-355. doi: 10.1016/j.immuni.2015.01.010

Gur, Chamutal, et al. "Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack." Immunity, vol. 42, no. 2, 2015, pp. 344-355. https://doi.org/10.1016/j.immuni.2015.01.010

Gur, Chamutal, Yara Ibrahim, Batya Isaacson, Rachel Yamin, Jawad Abed, Moriya Gamliel, Jonatan Enk, et al. "Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack." Immunity 42, no. 2 (2015): 344-355. https://doi.org/10.1016/j.immuni.2015.01.010

Gur, C., et al. (2015) 'Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack', Immunity, 42(2), pp. 344-355. doi: 10.1016/j.immuni.2015.01.010

Gur C, Ibrahim Y, Isaacson B, Yamin R, Abed J, Gamliel M, and sur.. Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack. Immunity [Internet]. 2015 February [cited 2024 May 13];42(2):344-355. doi: 10.1016/j.immuni.2015.01.010

C. Gur, et al., "Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack", Immunity, vol. 42, no. 2, pp. 344-355, February 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:992646. [Accessed: 13 May 2024]

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Metadata
Title (english)Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack
AuthorChamutal Gur
AuthorYara Ibrahim
AuthorBatya Isaacson
AuthorRachel Yamin
AuthorJawad Abed
AuthorMoriya Gamliel
AuthorJonatan Enk
AuthorYotam Bar-On
AuthorNoah Stanietsky-Kaynan
AuthorShunit Coppenhagen-Glazer
AuthorNoam Shussman
AuthorGideon Almogy
AuthorAngelica Cuapio
AuthorErhard Hofer
AuthorDror Mevorach
AuthorAdi Tabib
AuthorRona Ortenberg
AuthorGal Markel
AuthorKarmela Miklić
AuthorStipan Jonjić
AuthorCaitlin A. Brennan
AuthorWendy S. Garrett
AuthorGilad Bachrach
AuthorOfer Mandelboim
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Bacteria, such as Fusobacterium nucleatum, are present in the tumor microenvironment. However, the immunological consequences of intra-tumoral bacteria remain unclear. Here, we have shown that natural killer (NK) cell killing of various tumors is inhibited in the presence of various F. nucleatum strains. Our data support that this F. nucleatum- mediated inhibition is mediated by human, but not by mouse TIGIT, an inhibitory receptor present on all human NK cells and on various T cells. Using a library of F. nucleatum mutants, we found that the Fap2 protein of F. nucleatum directly interacted with TIGIT, leading to the inhibition of NK cell cytotoxicity. We have further demonstrated that tumor- infiltrating lymphocytes expressed TIGIT and that T cell activities were also inhibited by F. nucleatum via Fap2. Our results identify a bacterium- dependent, tumorimmune evasion mechanism in which tumors exploit the Fap2 protein of F. nucleatum to inhibit immune cell activity via TIGIT.
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleImmunity
Numberingvol. 42, no. 2, pp. 344-355
p-ISSN1074-7613
DOIhttps://doi.org/10.1016/j.immuni.2015.01.010
URN:NBNurn:nbn:hr:184:992646
Publication2015-02
ProjectNumber: 322693
Title (english): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Acronym: STADVINN
Jurisdiction: eu
Funding stream: FP7
ProjectNumber: 317013
Title (english): Natural Killer Cell-Based Anti-Cancer Immunotherapies:Research training in molecular medicine and biotechnology business
Acronym: NATURIMMUN
Jurisdiction: eu
Funding stream: FP7
ProjectNumber: 320473
Title (english): Recognition of bacteria by NK cells
Acronym: BACNK
Jurisdiction: eu
Funding stream: FP7
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S1074761315000369
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2018-12-04 22:13:52