| Abstract (croatian) | Cilj: Procijeniti utječu li količina i distribucija masnog tkiva na karakteristike i agresivnost karcinoma dojke u postmenopauzalnih žena.
Ispitanici i metode: Istraživanje je obuhvatilo 70 postmenopauzalnih žena s invazivnim karcinomom dojke. Bolesnicama su u trenutku postavljanja dijagnoze uzete antropometrijske mjere (tjelesna visina-TV, tjelesna masa-TM, opseg struka-OS, opseg bokova-OB) te su izračunati pridruženi indeks tjelesne mase (ITM) i waist hip ratio (WHR). Iz patohistoloških nalaza prikupili su se podaci o karakteristikama tumora: veličina, histološki gradus, ekspresija estrogenskih (ER) i progesteronskih receptora (PR), HER2 i Ki67 te imunohistokemijski tip tumora.
Rezultati: Bolesnice su bile prosječne dobi 65 godina (42-86), TV 164,8±7,0 cm, TM 75,6±14,5 kg, ITM 27,9±5,3 kg/m2, OS 90,5±12,4 cm, OB 107,6±11,7 cm, WHR 0,84±0,07. Raspodjelom u skupine s obzirom na pridruženi ITM, uz pomoć hi-kvadrat testa dokazala se statistički značajno veća pojavnost estrogen pozitivnih (n=41, 91,1% vs n=18, 72,0%; P=0,037), progesteron pozitivnih (n=38, 84,4% vs n=11, 44,0%; P<0,001) te luminal A karcinoma dojke (n=15, 33,3% vs n=2, 8,0%; P=0,019) u skupini prekomjerno uhranjenih (ITM>25 kg/m2). Nadalje, raspodjelom prema OS dokazala se statistički značajno češća pojavnost estrogen pozitivnih (n=52, 88,1% vs n=7, 63,6%; P=0,042), progesteron pozitivnih (n=45, 76,3% vs n=4, 36,4%; P=0,008) i luminal A karcinoma dojke (n=17, 28,8% vs n=0, 0%; P=0,042) te statistički značajno rijeđa pojavnost trostruko negativnih karcinoma dojke (n=1, 1,7% vs n=2, 18,2%; P=0,014) u skupini s OS>80 cm.
Zaključci: S količinom masnog tkiva raste stupanj ekspresije progesterona i estrogena. Potonje bi se moglo objasniti porastom ekspresije aromataze u masnom tkivu. |
| Abstract (english) | Aim: To investigate a potential connection between breast cancer characteristics and adipose tissue quantity and distribution in postmenopausal women.
Patients and methods: The study included 70 postmenopausal women diagnosed with invasive breast cancer. Overall anthropometric measures (weight, height, waist circumference-WC, hip circumference-HC, body mass index-BMI, waist hip ratio-WHR) and pathohistological data (tumor size, histological grade, estrogen-ER receptor, progesterone-PR receptor, HER2 and Ki67 expression, immunohistochemical tumor type) were collected.
Results: Average age was 65 years (42-86), height 164,8±7,0 cm, weight 75,6±14,5 kg, BMI 27,9±5,3 kg/m2, WC 90,5±12,4 cm, HC 107,6±11,7 cm, WHR 0,84±0,07. Estrogen positive (n=41, 91,1% vs n=18, 72,0%; P=0,037), progesterone positive (n=38, 84,4% vs n=11, 44,0%; P<0,001) and luminal A breast cancers (n=15, 33,3% vs n=2, 8,0%; P=0,019) were significantly more frequent in BMI>25 kg/m2 group. Moreover, estrogen positive (n=52, 88,1% vs n=7, 63,6%; P=0,042), progesterone positive (n=45, 76,3% vs n=4, 36,4%; P=0,008) and luminal A breast cancers (n=17, 28,8% vs n=0, 0%; P=0,042) were significantly more frequent in patients with WC>80 cm, while there was also a significantly lower number of triple negative breast cancers in the latter group (n=1, 1,7% vs n=2, 18,2%; P=0,014).
Conclusions: PR and ER expression positively correlates with adipose tissue quantity, most probably due to higher expression of aromatase. |
