prikaz prve stranice dokumenta Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 
  Download
PDF 1.41 MB
Scientific paper - Original scientific paper
Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 
Proceedings of the National Academy of Sciences, 110 (2013), 41; 16550-16555. https://doi.org/10.1073/pnas.1310215110
Tršan, Tihana; Busche, Andreas; Abram, Maja; Wensveen, F. M.; Lemmermann, N. A.; Arapović, Maja; Babić, Marina; Tomić, Adriana; Golemac, Mijo; Brinkmann, Melanie M.; Jager, W.; Oxenius, A.; Polić, Bojan; Krmpotić, Astrid; Messerle, M.; Jonjić, Stipan More authors...

Cite this document

Tršan, T., Busche, A., Abram, M., Wensveen, F. M., Lemmermann, N. A., Arapović, M. ... Jonjić, S. (2013). Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 . Proceedings of the National Academy of Sciences, 110. (41), 16550-16555. doi: 10.1073/pnas.1310215110

Tršan, Tihana, et al. "Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ." Proceedings of the National Academy of Sciences, vol. 110, no. 41, 2013, pp. 16550-16555. https://doi.org/10.1073/pnas.1310215110

Tršan, Tihana, Andreas Busche, Maja Abram, F. M. Wensveen, N. A. Lemmermann, Maja Arapović, Marina Babić, et al. "Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ." Proceedings of the National Academy of Sciences 110, no. 41 (2013): 16550-16555. https://doi.org/10.1073/pnas.1310215110

Tršan, T., et al. (2013) 'Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ', Proceedings of the National Academy of Sciences, 110(41), pp. 16550-16555. doi: 10.1073/pnas.1310215110

Tršan T, Busche A, Abram M, Wensveen FM, Lemmermann NA, Arapović M, and sur.. Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 . Proceedings of the National Academy of Sciences [Internet]. 2013 September 19 [cited 2024 November 12];110(41):16550-16555. doi: 10.1073/pnas.1310215110

T. Tršan, et al., "Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 ", Proceedings of the National Academy of Sciences, vol. 110, no. 41, pp. 16550-16555, September 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:913348. [Accessed: 12 November 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1 
AuthorTihana Tršan
AuthorAndreas Busche
AuthorMaja Abram
AuthorF. M. Wensveen
AuthorN. A. Lemmermann
AuthorMaja Arapović
AuthorMarina Babić
AuthorAdriana Tomić
AuthorMijo Golemac
AuthorMelanie M. Brinkmann
AuthorW. Jager
AuthorA. Oxenius
AuthorBojan Polić
AuthorAstrid Krmpotić
AuthorM. Messerle
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Due to a unique pattern of CD8 T-cell response induced by cytomegaloviruses (CMVs), live attenuated CMVs are attractive candidates for vaccine vectors for a number of clinically relevant infections and tumors. NKG2D is one of the most important activating NK cell receptors that plays a role in costimulation of CD8 T cells. Here we demonstrate that the expression of CD8 T-cell epitope of Listeria monocytogenes by a recombinant mouse CMV (MCMV) expressing the NKG2D ligand retinoic acid early-inducible protein 1-gamma (RAE-1γ) dramatically enhanced the effectiveness and longevity of epitope-specific CD8 T-cell response and conferred protection against a subsequent challenge infection with Listeria monocytogenes. Unexpectedly, theattenuatedgrowth in vivo of the CMV vector expressing RAE-1γ and its capacity to enhance specific CD8 T-cell response were preserved even in mice lacking NKG2D, implying additional immune function for RAE-1γ beyond engagement of NKG2D. Thus, vectors expressing RAE-1γ represent a promising approach in the development of CD8 T-cell– based vaccines
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleProceedings of the National Academy of Sciences
Numberingvol. 110, no. 41, pp. 16550-16555
p-ISSN0027-8424
e-ISSN1091-6490
DOIhttps://doi.org/10.1073/pnas.1310215110
URN:NBNurn:nbn:hr:184:913348
Publication2013-09-19
Publication2013-10-08
ProjectNumber: 322693
Title (english): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Acronym: STADVINN
Jurisdiction: eu
Funding stream: FP7
Document URLhttp://www.pnas.org/cgi/doi/10.1073/pnas.1310215110
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-22 22:42:42