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master's thesis
Uloga kalpaina u karcinomu dojke
2018. urn:nbn:hr:184:824580
Baumgartner, Tihana
University of Rijeka
Faculty of Medicine
Department of General Pathology and Pathological Anatomy

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Baumgartner, T. (2018). Uloga kalpaina u karcinomu dojke (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:824580

Baumgartner, Tihana. "Uloga kalpaina u karcinomu dojke." Master's thesis, University of Rijeka, Faculty of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:184:824580

Baumgartner, Tihana. "Uloga kalpaina u karcinomu dojke." Master's thesis, University of Rijeka, Faculty of Medicine, 2018. https://urn.nsk.hr/urn:nbn:hr:184:824580

Baumgartner, T. (2018). 'Uloga kalpaina u karcinomu dojke', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 14 November 2024, https://urn.nsk.hr/urn:nbn:hr:184:824580

Baumgartner T. Uloga kalpaina u karcinomu dojke [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2018 [cited 2024 November 14] Available at: https://urn.nsk.hr/urn:nbn:hr:184:824580

T. Baumgartner, "Uloga kalpaina u karcinomu dojke", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:184:824580

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Metadata
TitleUloga kalpaina u karcinomu dojke
Title (english)The role of calpain in breast cancer
AuthorTihana Baumgartner
MentorElvira Mustać (mentor)
Committee memberNives Jonjić (predsjednik povjerenstva)
Committee memberIvana Marić (član povjerenstva)
Committee memberEmina Babarović (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Rijeka
Defense date and country2018-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract
Rak dojke je heterogena bolest obilježena morfološkom raznolikošću i različitim biološkim ponašanjem koje utječe na progresiju same bolesti, a time i na terapeutsku otpornost. Kalpainski sustav je važna obitelj proteolitičkih enzima koja igra ulogu u velikom broju osnovnih staničnih aktivnosti uključujući preživljavanje stanica, apoptozu i migraciju. Promijenjena aktivnost i ekspresija članova kalpainske obitelji uključeni su u brojnim bolestima, uključujući rak. Prikupljene informacije o karcinomu dojke su pokazale da kalpain igra važnu ulogu u progresiji bolesti, prognozi i odgovoru na liječenje. Trenutna istraživanja o karcinomu dojke upućuju na to da određivanje ekspresije i aktivnosti kalpaina može imati kliničku korist pri određivanju prognoze pacijenata i također se može pokazati korisnim pri odabiru pacijenata za personaliziranu terapiju. No, i dalje su potrebna istraživanja kako bi se razjasnila uloga kalpaina i kalpainskog enzimskog sustava u karcinomu dojke i karcinomima općenito.
Abstract (english)
Breast cancer is a heterogeneous disease that is characterized by diversity of morphology and many biological behaviors that influence the progression of the disease and thus therapeutic resistance. The calpain system is a family of proteolytic enzymes that has a role in a number of basic cellular activities and it includes survival of cells, migration and apoptosis. Changed expression and activity of members of the calpain family are involved in various diseases, including cancer. The information collected on breast cancer has demonstrated that calpain has a significant role in progression and prognosis of disease and response to treatment. Present breast cancer research indicates that the assesment of expression and activity of calpain can have a clinical benefit in assesing patient prognosis and can also be useful in selecting patients for personalized therapy. Nevertheless, research is still required to clarify the role of the calpain enzyme system regarding breast cancer and carcinoma in general.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:824580
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-11-15 15:02:46