prikaz prve stranice dokumenta Altered NK Cell Development and Enhanced NK Cell-Mediated Resistance to Mouse Cytomegalovirus in NKG2D-Deficient Mice
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Scientific paper - Original scientific paper
Altered NK Cell Development and Enhanced NK Cell-Mediated Resistance to Mouse Cytomegalovirus in NKG2D-Deficient Mice
Immunity, 31 (2009), 2; 270-282. https://doi.org/10.1016/j.immuni.2009.06.017
Zafirova, Biljana; Mandarić, Sanja; Antulov, Ronald; Krmpotić, Astrid; Jonsson, Helena; Yokoyama, Wayne M.; Jonjić, Stipan; Polić, Bojan

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Zafirova, B., Mandarić, S., Antulov, R., Krmpotić, A., Jonsson, H., Yokoyama, W. M. ... Polić, B. (2009). Altered NK Cell Development and Enhanced NK Cell-Mediated Resistance to Mouse Cytomegalovirus in NKG2D-Deficient Mice. Immunity, 31. (2), 270-282. doi: 10.1016/j.immuni.2009.06.017

Zafirova, Biljana, et al. "Altered NK Cell Development and Enhanced NK Cell-Mediated Resistance to Mouse Cytomegalovirus in NKG2D-Deficient Mice." Immunity, vol. 31, no. 2, 2009, pp. 270-282. https://doi.org/10.1016/j.immuni.2009.06.017

Zafirova, Biljana, Sanja Mandarić, Ronald Antulov, Astrid Krmpotić, Helena Jonsson, Wayne M. Yokoyama, Stipan Jonjić and Bojan Polić. "Altered NK Cell Development and Enhanced NK Cell-Mediated Resistance to Mouse Cytomegalovirus in NKG2D-Deficient Mice." Immunity 31, no. 2 (2009): 270-282. https://doi.org/10.1016/j.immuni.2009.06.017

Zafirova, B., et al. (2009) 'Altered NK Cell Development and Enhanced NK Cell-Mediated Resistance to Mouse Cytomegalovirus in NKG2D-Deficient Mice', Immunity, 31(2), pp. 270-282. doi: 10.1016/j.immuni.2009.06.017

Zafirova B, Mandarić S, Antulov R, Krmpotić A, Jonsson H, Yokoyama WM, and sur.. Altered NK Cell Development and Enhanced NK Cell-Mediated Resistance to Mouse Cytomegalovirus in NKG2D-Deficient Mice. Immunity [Internet]. 2009 August [cited 2024 November 13];31(2):270-282. doi: 10.1016/j.immuni.2009.06.017

B. Zafirova, et al., "Altered NK Cell Development and Enhanced NK Cell-Mediated Resistance to Mouse Cytomegalovirus in NKG2D-Deficient Mice", Immunity, vol. 31, no. 2, pp. 270-282, August 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:142440. [Accessed: 13 November 2024]

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Metadata
Title (english)Altered NK Cell Development and Enhanced NK Cell-Mediated Resistance to Mouse Cytomegalovirus in NKG2D-Deficient Mice
AuthorBiljana Zafirova
AuthorSanja Mandarić
AuthorRonald Antulov
AuthorAstrid Krmpotić
AuthorHelena Jonsson
AuthorWayne M. Yokoyama
AuthorStipan Jonjić
AuthorBojan Polić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
NKG2D is a potent activating receptor on natural killer (NK) cells and acts as a molecular sensor for stressed cells expressing NKG2D ligands such as infected or tumor-transformed cells. Although NKG2D is expressed on NK cell precursors, its role in NK cell development is not known. We have generated NKG2D-deficient mice by targeting the Klrk1 locus. Here we provide evidence for an important regulatory role of NKG2D in the development of NK cells. The absence of NKG2D caused faster division of NK cells, perturbation in size of some NK cell subpopulations, and their augmented sensitivity to apoptosis. As expected, Klrk1(-/-) NK cells are less responsive to tumor targets expressing NKG2D ligands. Klrk1(-/-) mice, however, showed an enhanced NK cell-mediated resistance to mouse cytomegalovirus infection as a consequence of NK cell dysregulation. Altogether, these findings provide evidence for regulatory function of NKG2D in NK cell physiology.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleImmunity
Numberingvol. 31, no. 2, pp. 270-282
p-ISSN1074-7613
DOIhttps://doi.org/10.1016/j.immuni.2009.06.017
URN:NBNurn:nbn:hr:184:142440
Publication2009-08
Document URLhttp://linkinghub.elsevier.com/retrieve/pii/S107476130900315X
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-08 20:03:51