prikaz prve stranice dokumenta The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells
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Scientific paper - Original scientific paper
The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells
European Journal of Immunology, 43 (2013); 2151-2161. https://doi.org/10.1002/eji.201343433
Lankry, Dikla; Lenac Roviš, Tihana; Jonjić, Stipan; Mandelboim, Ofer

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Lankry, D., Lenac Roviš, T., Jonjić, S. & Mandelboim, O. (2013). The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells. European Journal of Immunology, 43., 2151-2161. doi: 10.1002/eji.201343433

Lankry, Dikla, et al. "The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells." European Journal of Immunology, vol. 43, 2013, pp. 2151-2161. https://doi.org/10.1002/eji.201343433

Lankry, Dikla, Tihana Lenac Roviš, Stipan Jonjić and Ofer Mandelboim. "The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells." European Journal of Immunology 43 (2013): 2151-2161. https://doi.org/10.1002/eji.201343433

Lankry, D., et al. (2013) 'The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells', European Journal of Immunology, 43, pp. 2151-2161. doi: 10.1002/eji.201343433

Lankry D, Lenac Roviš T, Jonjić S, Mandelboim O. The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells. European Journal of Immunology [Internet]. 2013 [cited 2024 December 24];43:2151-2161. doi: 10.1002/eji.201343433

D. Lankry, T. Lenac Roviš, S. Jonjić and O. Mandelboim, "The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells", European Journal of Immunology, vol. 43, pp. 2151-2161, 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:420865. [Accessed: 24 December 2024]

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Metadata
Title (english)The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells
AuthorDikla Lankry
AuthorTihana Lenac Roviš
AuthorStipan Jonjić
AuthorOfer Mandelboim
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The activity of NK cells is controlled by inhibitory and activating receptors. The inhibitory receptors interact mostly with MHC class I proteins, however, inhibitory receptors such as CD300a, which bind to non‐MHC class I ligands, also exist. Recently, it was discovered that phosphatidylserine (PS) is a ligand for CD300a and that the interaction between PS expressed on apoptotic cells and CD300a inhibits the uptake of apoptotic cells by phagocytic cells. Whether PS can inhibit NK‐cell activity through CD300a is unknown. Here, we have generated specific antibodies directed against CD300a and we used these mAbs to demonstrate that various NK‐cell clones express different levels of CD300a. We further demonstrated that both CD300a and its highly homologous molecule CD300c bind to the tumor cells equally well and that they recognize PS and additional unknown ligand(s) expressed by tumor cells. Finally, we showed that blocking the PS–CD300a interaction resulted in increased NK‐cell killing of tumor cells. Collectively, we demonstrate a new tumor immune evasion mechanism that is mediated through the interaction between PS and CD300a and we suggest that CD300c, similarly to CD300a, also interacts with PS.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Journal of Immunology
Numberingvol. 43, pp. 2151-2161
p-ISSN0014-2980
e-ISSN1521-4141
DOIhttps://doi.org/10.1002/eji.201343433
URN:NBNurn:nbn:hr:184:420865
Publication2013
Document URLhttps://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201343433
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-10-14 18:03:01