prikaz prve stranice dokumenta Statin use is not associated with an increased risk of acute pancreatitis-A meta-analysis of observational studies
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Scientific paper - Review paper
Statin use is not associated with an increased risk of acute pancreatitis-A meta-analysis of observational studies
United European Gastroenterology Journal, 6 (2018), 8; 1206-1214. https://doi.org/10.1177/2050640618781168
Poropat, Goran; Archibugi, Livia; Korpela, Taija; Cárdenas-Jaén, Karina; de-Madaria, Enrique; Carpuso, Gabriele

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Poropat, G., Archibugi, L., Korpela, T., Cárdenas Jaén, K., de Madaria, E. & Carpuso, G. (2018). Statin use is not associated with an increased risk of acute pancreatitis-A meta-analysis of observational studies. United European Gastroenterology Journal, 6. (8), 1206-1214. doi: 10.1177/2050640618781168

Poropat, Goran, et al. "Statin use is not associated with an increased risk of acute pancreatitis-A meta-analysis of observational studies." United European Gastroenterology Journal, vol. 6, no. 8, 2018, pp. 1206-1214. https://doi.org/10.1177/2050640618781168

Poropat, Goran, Livia Archibugi, Taija Korpela, Karina Cárdenas Jaén, Enrique de Madaria and Gabriele Carpuso. "Statin use is not associated with an increased risk of acute pancreatitis-A meta-analysis of observational studies." United European Gastroenterology Journal 6, no. 8 (2018): 1206-1214. https://doi.org/10.1177/2050640618781168

Poropat, G., et al. (2018) 'Statin use is not associated with an increased risk of acute pancreatitis-A meta-analysis of observational studies', United European Gastroenterology Journal, 6(8), pp. 1206-1214. doi: 10.1177/2050640618781168

Poropat G, Archibugi L, Korpela T, Cárdenas Jaén K, de Madaria E, Carpuso G. Statin use is not associated with an increased risk of acute pancreatitis-A meta-analysis of observational studies. United European Gastroenterology Journal [Internet]. 2018 [cited 2024 December 14];6(8):1206-1214. doi: 10.1177/2050640618781168

G. Poropat, L. Archibugi, T. Korpela, K. Cárdenas Jaén, E. de Madaria and G. Carpuso, "Statin use is not associated with an increased risk of acute pancreatitis-A meta-analysis of observational studies", United European Gastroenterology Journal, vol. 6, no. 8, pp. 1206-1214, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:293058. [Accessed: 14 December 2024]

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Metadata
Title (english)Statin use is not associated with an increased risk of acute pancreatitis-A meta-analysis of observational studies
AuthorGoran Poropat
AuthorLivia Archibugi
AuthorTaija Korpela
AuthorKarina Cárdenas-Jaén
AuthorEnrique de-Madaria
AuthorGabriele Carpuso
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
BACKGROUND: Statins are perceived as potential etiological factors for acute pancreatitis (AP), but recent evidence suggests the opposite. Our aim was to evaluate the association between statin use and risk of AP in observational studies. METHODS: Medline, Scopus, and Web of Science were searched for cohort (C) and case-control (CC) studies evaluating statins as intervention and AP as outcome. Pooled adjusted odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated. RESULTS: Thirteen studies (seven CC, six C) with 34,899 AP patients and 5,377,894 controls were included. Prevalence of statin use was 9.8% among AP patients and 25% among controls. Pooled adjusted OR was 1.00 (95% CI = 0.63 to 1.59) with considerable heterogeneity (I 2 = 98%). CC studies were associated with increased AP risk (OR = 1.33; 95% CI = 1.20 to 1.47), unlike C studies (OR = 0.69; 95% CI = 0.37 to 1.31). No association with increased risk was found for studies from Western countries (OR = 0.90; 95% CI = 0.52 to 1.56), unlike for studies conducted in Asia (OR = 1.39; 95% CI = 1.10 to 1.75). CONCLUSION: Statin use is not associated with increased risk of AP. Increased risk was limited to CC studies, which are more prone to bias, while C studies showed no global effect. Further research is needed to clarify whether statin type, dosage, treatment duration or AP etiology might account for this difference
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleUnited European Gastroenterology Journal
Numberingvol. 6, no. 8, pp. 1206-1214
p-ISSN2050-6406
e-ISSN2050-6414
DOIhttps://doi.org/10.1177/2050640618781168
URN:NBNurn:nbn:hr:184:293058
Publication2018
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169058/pdf/10.1177_2050640618781168.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-10-10 21:09:56