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Scientific paper - Original scientific paper
Helicobacter pylori – otpornost na antibiotike u Primorsko-goranskoj županiji
Medicina Fluminensis : Medicina Fluminensis, 54 (2018), 3; 274-281. https://doi.org/10.21860/medflum2018_203550
Bubonja-Šonje, Marina; Gregorović-Kesovija, Palmira; Ambrožić, Damir; Pružinec-Popović, Blanka; Abram, Maja

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Bubonja Šonje, M., Gregorović Kesovija, P., Ambrožić, D., Pružinec Popović, B. & Abram, M. (2018). Helicobacter pylori – otpornost na antibiotike u Primorsko-goranskoj županiji. Medicina Fluminensis : Medicina Fluminensis, 54. (3), 274-281. doi: 10.21860/medflum2018_203550

Bubonja Šonje, Marina, et al. "Helicobacter pylori – otpornost na antibiotike u Primorsko-goranskoj županiji." Medicina Fluminensis : Medicina Fluminensis, vol. 54, no. 3, 2018, pp. 274-281. https://doi.org/10.21860/medflum2018_203550

Bubonja Šonje, Marina, Palmira Gregorović Kesovija, Damir Ambrožić, Blanka Pružinec Popović and Maja Abram. "Helicobacter pylori – otpornost na antibiotike u Primorsko-goranskoj županiji." Medicina Fluminensis : Medicina Fluminensis 54, no. 3 (2018): 274-281. https://doi.org/10.21860/medflum2018_203550

Bubonja Šonje, M., et al. (2018) 'Helicobacter pylori – otpornost na antibiotike u Primorsko-goranskoj županiji', Medicina Fluminensis : Medicina Fluminensis, 54(3), pp. 274-281. doi: 10.21860/medflum2018_203550

Bubonja Šonje M, Gregorović Kesovija P, Ambrožić D, Pružinec Popović B, Abram M. Helicobacter pylori – otpornost na antibiotike u Primorsko-goranskoj županiji. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2018 September 01 [cited 2024 April 16];54(3):274-281. doi: 10.21860/medflum2018_203550

M. Bubonja Šonje, P. Gregorović Kesovija, D. Ambrožić, B. Pružinec Popović and M. Abram, "Helicobacter pylori – otpornost na antibiotike u Primorsko-goranskoj županiji", Medicina Fluminensis : Medicina Fluminensis, vol. 54, no. 3, pp. 274-281, September 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:455316. [Accessed: 16 April 2024]

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Metadata
Title (croatian)Helicobacter pylori – otpornost na antibiotike u Primorsko-goranskoj županiji
Title (english)Helicobacter pylori resistance to antibiotics in Primorsko-goranska county
AuthorMarina Bubonja-Šonje
AuthorPalmira Gregorović-Kesovija
AuthorDamir Ambrožić
AuthorBlanka Pružinec-Popović
AuthorMaja Abram
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Microbiology and Parasitology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Medical Microbiology
Abstract (croatian)
Cilj: Niti za jednu bakterijsku infekciju ne postoji toliko različitih terapijskih opcija kao za infekciju koju uzrokuje bakterija Helicobacter pylori za koju još uvijek nije pronađen optimalan terapijski pristup. Preporučene terapijske sheme koje se primjenjuju u empirijskom liječenju ovise o otpornosti helikobaktera na antimikrobne lijekove u određenoj regiji. No, empirijsko liječenje infekcije uz sve veći porast otpornosti helikobaktera na antibiotike često ima za ishod terapijski neuspjeh. Cilj ovog rada bio je utvrditi proširenost i trend otpornosti helikobaktera na antibiotike na području Primorsko-goranske županije (PGŽ) u petogodišnjem razdoblju. Metode: Statistički su obrađeni i interpretirani rezultati testiranja osjetljivosti H. pylori na antibiotike u razdoblju 2013-2017. godine. Podatci su dobiveni iz arhiva Kliničkog zavoda za kliničku mikrobiologiju Kliničkog bolničkog centra Rijeka te Mikrobiološkog odjela Nastavnog zavoda za javno zdravstvo PGŽ. Rezultati: Zabilježena je visoka stopa otpornosti H. pylori na klaritromicin i metronidazol, niska stopa otpornosti na levofloksacin i sporadična otpornost na rifampicin i amoksicilin. U petogodišnjem razdoblju nije izoliran niti jedan soj otporan na tetraciklin. Zaključci: Visoka stopa rezistencije na klaritromicin i metronidazol, uz dvojnu rezistencija na oba antibiotika koja je pronađena u četvrtini izolata ograničava korištenje ovih antibiotika u empirijskim terapijskim shemama. Uočena je i zabrinjavajuća pojava višestruke otpornosti na antibiotike prisutna u 10% izolata koja dodatno otežava izbor odgovarajuće terapije. Praćenje i poznavanje antimikrobne otpornosti lokalnih izolata H. pylori je neophodno radi izrade odgovarajućih terapijskih smjernica.
Abstract (english)
Aim: There is no bacterial infection with so many different therapeutic options as for infection caused by Helicobacter pylori for which an optimal therapeutic approach has not yet been found. Recommended therapeutic schemes depend on H. pylori resistance to antimicrobial drugs in a particular region, however, empirical treatment of infections along with increasing resistance to antibiotics often results in a therapeutic failure. The aim of this study was to determine the trend and the prevalence of helicobacter antibiotic resistance in Primorsko-goranska county during the five-year period. Methods: This study presents the results of H. pylori antimicrobial susceptibility testing from year 2013 to 2017. Data were obtained from the archives of the Department of Clinical Microbiology, Clinical Hospital Centre Rijeka and the Department of Microbiology, Teaching Institute of Public Health of Primorsko-Goranska County. Results: High-level resistance to clarithromycin and metronidazole was noticed. Rare resistance to levofloxacin was observed whereas resistance to rifampicin and amoxicillin was found sporadically. Resistance to tetracycline was not detected. Conclusions: The high resistance rate to metronidazole and clarithromycin as well as high dual resistance to both antibiotics observed in about a quarter clinical isolates can impair the efficacy of these antimicrobials in empirical eradication treatment. In addition, worrying appearance of multiple resistance to antibiotics in 10% of isolates was observed. Surveillance of local antimicrobial resistance is necessary in order to establish the relevant treatment guidelines.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 54, no. 3, pp. 274-281
p-ISSN1847-6864
e-ISSN1848-1868
DOIhttps://doi.org/10.21860/medflum2018_203550
URN:NBNurn:nbn:hr:184:455316
Publication2018-09-01
Document URLhttps://hrcak.srce.hr/203550
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-09-05 17:04:44