prikaz prve stranice dokumenta Toksični učinci celastrola na BV-2 mikorglija staničnoj liniji
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master's thesis
Toksični učinci celastrola na BV-2 mikorglija staničnoj liniji
2015. urn:nbn:hr:184:488506
Brusić, Iva
University of Rijeka
Faculty of Medicine
Department of Pharmacology

Cite this document

Brusić, I. (2015). Toksični učinci celastrola na BV-2 mikorglija staničnoj liniji (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:488506

Brusić, Iva. "Toksični učinci celastrola na BV-2 mikorglija staničnoj liniji." Master's thesis, University of Rijeka, Faculty of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:184:488506

Brusić, Iva. "Toksični učinci celastrola na BV-2 mikorglija staničnoj liniji." Master's thesis, University of Rijeka, Faculty of Medicine, 2015. https://urn.nsk.hr/urn:nbn:hr:184:488506

Brusić, I. (2015). 'Toksični učinci celastrola na BV-2 mikorglija staničnoj liniji', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:184:488506

Brusić I. Toksični učinci celastrola na BV-2 mikorglija staničnoj liniji [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2015 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:184:488506

I. Brusić, "Toksični učinci celastrola na BV-2 mikorglija staničnoj liniji", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:184:488506

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Metadata
TitleToksični učinci celastrola na BV-2 mikorglija staničnoj liniji
AuthorIva Brusić
MentorJasenka Mršić-Pelčić (mentor)
MentorNatalia Kučić (komentor)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Rijeka
Defense date and country2015, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract
Mikroglija stanice predstavljaju obranu SŽS koje ispunjavaju važne zadatke. Tijekom upale dolazi do aktivacije i migracije mikroglija stanica, te oslobađanja medijatora upale. Celastrol, kineska ljekovita biljka se stoljećima uspješno koristi u liječenju raznih bolesti jer ima snažnu terapeutsku učinkovitost za autoimune i upalne bolesti. Cilj ovog rada bio je ispitati djelovanje celastrola na BV-2 mikroglija stanice kojima je inducirana hipoksija u trajanju od 6 h. Praćene su promijene morfoloških obilježja stanica te njihovog broja, i izražaj markera upale COX-2. Smanjenjem broja mikroglija stanica i promjena njihove morfologije pokazatelji su toksičnog učinka celastrola i hipoksije u kombinaciji. Smanjena ekspresija indikatora upale COX-2 dovodi do zaključka da celastrol djeluje protuupalno.
Abstract (english)
Microglial cells are defense of the central nervous system and they have many important tasks. Microglia cells are being activated and they migrate during the inflammation process which also releases inflammatory mediators. Celastrol, chinese medical herb has been used successfully for centuries in the treatment of various diseases because it has a strong therapeutic effect on autoimmune and inflammatory diseases. The aim of this study was to investigate the effect of celastrol on BV-2 microglial cells which were exposed to hypoxia in a period of 6 hours. We looked for morphological changes of microglial cells, their number, and the expression of the marker COX-2. By decrease of the number of microglial cells and by the change in their morphology we see toxic effects of celastrol and hypoxia. Reduced expression of COX-2 indicator of inflammation leads to the conclusion that celastrol has anti-inflammatory activity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:488506
Study programmeTitle: Study of Sanitary Engineering
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra sanitarnog inženjerstva (magistar/magistra sanitarnog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2016-02-16 10:01:04