Injuries of hands are very common and account for 50% of all human injuries, of which amputation injuries are relatively frequent. In adults, amputations are usually a result of handling various machines (such as circular saws), while children’s amputations often occur during a child’s use of house appliances (blender and slicers), and on playgrounds with inadequately maintained playground equipment. Optimal amputations are considered to be of "guillotine" type, and the most unfavorable are extensive contusive amputations with high contamination. Treatment of amputation injuries includes first aid procedures – stopping the bleeding, shock treatments, pain relief, immobilization and elevation of the injured limb. Due to the complex motor functions of the hand, it is especially important to reconstruct all the affected structures (skin, blood vessels, nerves, tendons and bones). Replantation (sewing) is necessary in the case of amputation in children, amputation of several fingers, thumb amputation and amputation of the wrist. Preoperative preparation of the stump and the amputated part determines the outcome of replantation. The delicate size of all the structure of the hand requires microsurgical techniques and great patience of a surgeon. The postoperative care includes general monitoring measures of the replanted hand (color, turgor pressure, temperature and capillary filling); keeping the extremity in elevated position; antibiotic and anticoagulant therapy, and instructing the patient to completely refrain from smoking.