Murine cytomegalovirus infection
 induces susceptibility to eae in
 resistant BalB/c Mice

Milovanović, Jelena; Popović, Branka; Milovanović, Marija; Kveštak, Daria; Arsenijević, Aleksandar; Stojanović, Bojana; Tanasković, Irena; Krmpotić, Astrid; Arsenijević, Nebojša; Jonjić, Stipan; Lukić, Miodrag L.

doi:10.3389/fimmu.2017.00192

prikaz prve stranice dokumenta Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice

Download
PDF 8.34 MB

Scientific paper - Original scientific paper

Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice

Frontiers in Immunology, 8 (2017); 192. https://doi.org/10.3389/fimmu.2017.00192

Milovanović, Jelena; Popović, Branka; Milovanović, Marija; Kveštak, Daria; Arsenijević, Aleksandar; Stojanović, Bojana; Tanasković, Irena; Krmpotić, Astrid; Arsenijević, Nebojša; Jonjić, Stipan; Lukić, Miodrag L.

Cite this document

APA 6th Edition

Milovanović, J., Popović, B., Milovanović, M., Kveštak, D., Arsenijević, A., Stojanović, B. ... Lukić, M. L. (2017). Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice. Frontiers in Immunology, 8.. doi: 10.3389/fimmu.2017.00192

MLA 8th Edition

Milovanović, Jelena, et al. "Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice." Frontiers in Immunology, vol. 8, 2017. https://doi.org/10.3389/fimmu.2017.00192

Chicago 17th Edition

Milovanović, Jelena, Branka Popović, Marija Milovanović, Daria Kveštak, Aleksandar Arsenijević, Bojana Stojanović, Irena Tanasković, et al. "Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice." Frontiers in Immunology 8 (2017). https://doi.org/10.3389/fimmu.2017.00192

Harvard

Milovanović, J., et al. (2017) 'Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice', Frontiers in Immunology, 8. doi: 10.3389/fimmu.2017.00192

Vancouver

Milovanović J, Popović B, Milovanović M, Kveštak D, Arsenijević A, Stojanović B, and sur.. Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice. Frontiers in Immunology [Internet]. 2017 February 27 [cited 2024 December 31];8. doi: 10.3389/fimmu.2017.00192

IEEE

J. Milovanović, et al., "Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice", Frontiers in Immunology, vol. 8, February 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:264272. [Accessed: 31 December 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:264272

Please login to the repository to save this object to your list.

Metadata

Title (english)	Murine cytomegalovirus infection induces susceptibility to eae in resistant BalB/c Mice
Author	Jelena Milovanović
Author	Branka Popović
Author	Marija Milovanović
Author	Daria Kveštak
Author	Aleksandar Arsenijević
Author	Bojana Stojanović
Author	Irena Tanasković
Author	Astrid Krmpotić
Author	Nebojša Arsenijević
Author	Stipan Jonjić
Author	Miodrag L. Lukić
Author's institution	University of Rijeka Faculty of Medicine (Center for Proteomics)
Author's institution	University of Rijeka Faculty of Medicine (Department of Histology and Embryology)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences Immunology
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences Cytology, Histology and Embryology
Abstract (english)	In contrast to C57BL/6 mice, BALB/c mice are relatively resistant to the induction of experimental autoimmune encephalomyelitis (EAE) after challenge with MOG35–55 peptide. Here, we provide the first evidence that infection with murine cytomegalovirus (MCMV) in adulthood abrogates this resistance. Infected BALB/c mice developed clinical and histological signs similar to those seen in susceptible C57BL/6 mice. In addition to CD4+ cells, large proportion of cells in the infiltrate of diseased BALB/c mice was CD8+, similar with findings in multiple sclerosis. CD8+ cells that responded to ex vivo restimulation with MOG35–55 were not specific for viral epitopes pp89 and m164. MCMV infection favors proinflammatory type of dendritic cells (CD86+CD40+CD11c+) in the peripheral lymph organs, M1 type of microglia in central nervous system, and increases development of Th1/Th17 encephalitogenic cells. This study indicates that MCMV may enhance autoimmune neuropathology and abrogate inherent resistance to EAE in mouse strain by enhancing proinflammatory phenotype of antigen-presenting cells, Th1/Th17, and CD8 response to MOG35–55.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	Frontiers in Immunology
Numbering	vol. 8, 192
e-ISSN	1664-3224
DOI	https://doi.org/10.3389/fimmu.2017.00192
URN:NBN	urn:nbn:hr:184:264272
Publication	2017-02-27
Document URL	https://www.frontiersin.org/articles/10.3389/fimmu.2017.00192/full
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2018-05-23 05:23:32