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Scientific paper - Original scientific paper
Multiple Sclerosis and Cancers in Croatia – A Possible Protective Role of the »Mediterranean Diet«
Collegium antropologicum, 33 (2009), 2; 539-545. urn:nbn:hr:184:210798
Materljan, Eris; Materljan, Mauro; Materljan, Branka; Vlačić, Helena; Barićev Novaković, Zdenka; Sepčić, Juraj

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Materljan, E., Materljan, M., Materljan, B., Vlačić, H., Barićev Novaković, Z. & Sepčić, J. (2009). Multiple Sclerosis and Cancers in Croatia – A Possible Protective Role of the »Mediterranean Diet«. Collegium antropologicum, 33. (2), 539-545. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:210798

Materljan, Eris, et al. "Multiple Sclerosis and Cancers in Croatia – A Possible Protective Role of the »Mediterranean Diet«." Collegium antropologicum, vol. 33, no. 2, 2009, pp. 539-545. https://urn.nsk.hr/urn:nbn:hr:184:210798

Materljan, Eris, Mauro Materljan, Branka Materljan, Helena Vlačić, Zdenka Barićev Novaković and Juraj Sepčić. "Multiple Sclerosis and Cancers in Croatia – A Possible Protective Role of the »Mediterranean Diet«." Collegium antropologicum 33, no. 2 (2009): 539-545. https://urn.nsk.hr/urn:nbn:hr:184:210798

Materljan, E., et al. (2009) 'Multiple Sclerosis and Cancers in Croatia – A Possible Protective Role of the »Mediterranean Diet«', Collegium antropologicum, 33(2), pp. 539-545. Available at: https://urn.nsk.hr/urn:nbn:hr:184:210798 (Accessed 08 April 2025)

Materljan E, Materljan M, Materljan B, Vlačić H, Barićev Novaković Z, Sepčić J. Multiple Sclerosis and Cancers in Croatia – A Possible Protective Role of the »Mediterranean Diet«. Collegium antropologicum [Internet]. 2009 July 01 [cited 2025 April 08];33(2):539-545. Available at: https://urn.nsk.hr/urn:nbn:hr:184:210798

E. Materljan, M. Materljan, B. Materljan, H. Vlačić, Z. Barićev Novaković and J. Sepčić, "Multiple Sclerosis and Cancers in Croatia – A Possible Protective Role of the »Mediterranean Diet«", Collegium antropologicum, vol. 33, no. 2, pp. 539-545, July 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:210798. [Accessed: 08 April 2025]

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Metadata
Title (english)Multiple Sclerosis and Cancers in Croatia – A Possible Protective Role of the »Mediterranean Diet«
AuthorEris Materljan
AuthorMauro Materljan
AuthorBranka Materljan
AuthorHelena Vlačić
AuthorZdenka Barićev Novaković
AuthorJuraj Sepčić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Neurology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Family Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Family Medicine
Abstract (english)
Multiple sclerosis (MS) is an autoimmune disease triggered by a combination of genetic and environmental risk factors which are however individually insufficient to provoke the disease. Previous investigations studied the coexistence of cancer in MS patients, and only a few relations between the geographic distribution of MS and that of cancer. The aim of this research was to find an environmental link between the aetiology of MS and cancers in Croatia. Incidence and prevalence of MS in Croatia... More were compared with the incidence of the most frequent cancer sites: stomach cancer, cancer of the colon and the rectum, pancreatic cancer, lung cancer, cancer of the kidneys and brain cancer. Data for MS were collected from seven population-based epidemiologic studies which used Poser’ s diagnostic criteria and reported the number of cases and the magnitude of the studied population. Data for cancers were drawn from the Croatian National Cancer Registry. The analysis was done for single municipalities, grouped in their belonging regions or counties, and separately for the continental and the coastal area. For each rate a 95% confidence interval was calculated. The differences between rates were tested with the chi-square test as well. In addition, MS incidence or prevalence were correlated with the corresponding cancer incidence data. Pearson’s correlation coefficients were used to measure the correlation between both diseases. Calculations were done with the statistical package Statistica V 7.1. and the Smith’s Statistical Package freeware In the continental area of Croatia the mean annual incidence (per 100,000 inhabitants) of MS was nearly two folds higher than in the coastal area: 2.1 vs. 1.3 (p=0.0029). The difference was lower when expressed by prevalence: 46.5 vs. 36.7 (p=0.0601). Among the malignant neoplasms, in the continental area significantly higher incidence rates were found for stomach (32.9 vs. 20.8; p=3.14E-14) and lung cancer (55.8 vs. 46.4; p=1.21E-05), whilst colon cancer alone (20.4 vs. 15.7; p=9.44E-05) or colorectal cancer (38.3 vs. 31.6; p=8.18E-05) had a significantly higher incidence in the coastal area. The geographic distribution of MS expressed by incidence was significantly correlated with pancreatic (r=0,62024, df=23, p=0.00094) and lung cancer (r=0,46380, df=23, p=0.01953). This research adds further malignant neoplasms, possibly exposure-related, to the list of diseases with geographic distribution like MS. The similarity of MS distribution with the named malignancies is unlikely to be incidental. MS in Gorski Kotar and Slavonia seems to be associated with a diet rich in meat and fat. A diet rich in fat and meat and poor in vegetables is a risk factor for stomach, colorectum, pancreatic as well as lung cancers. Some authors have documented a possible protective role of the »Mediterranean diet« for the named cancers. Olive oil is the main source of fat in the »Mediterranean diet«. Oleocanthal, a phenolic compound of the extra-virgin olive oil was found to inhibit the cyclooxigenase enzymes which are involved in demyelination and tumorigenesis. We hypothesize that the »Mediterranean diet«, olive oil and particularly oleocanthal, to have a protective role in MS too. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 33, no. 2, pp. 539-545
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:210798
Publication2009-07-01
Document URLhttps://hrcak.srce.hr/40544
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2018-05-23 04:58:48
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