prikaz prve stranice dokumenta A restrictive dose of crystalloids in patients during laparoscopic cholecystectomy is safe and cost-effective: prospective, two-arm parallel, randomized controlled trial
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Scientific paper - Original scientific paper
A restrictive dose of crystalloids in patients during laparoscopic cholecystectomy is safe and cost-effective: prospective, two-arm parallel, randomized controlled trial
Therapeutics and Clinical Risk Management, 14 (2018); 741-745. https://doi.org/10.2147/TCRM.S160778
Belavić, Matija; Sotošek Tokmadžić, Vlatka; Brozović Krijan, Antonija; Kvaternik, Ines; Matijaš, Kristina; Strikić, Nedjeljko; Žunić, Josip

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Belavić, M., Sotošek Tokmadžić, V., Brozović Krijan, A., Kvaternik, I., Matijaš, K., Strikić, N. & Žunić, J. (2018). A restrictive dose of crystalloids in patients during laparoscopic cholecystectomy is safe and cost-effective: prospective, two-arm parallel, randomized controlled trial. Therapeutics and Clinical Risk Management, 14., 741-745. doi: 10.2147/TCRM.S160778

Belavić, Matija, et al. "A restrictive dose of crystalloids in patients during laparoscopic cholecystectomy is safe and cost-effective: prospective, two-arm parallel, randomized controlled trial." Therapeutics and Clinical Risk Management, vol. 14, 2018, pp. 741-745. https://doi.org/10.2147/TCRM.S160778

Belavić, Matija, Vlatka Sotošek Tokmadžić, Antonija Brozović Krijan, Ines Kvaternik, Kristina Matijaš, Nedjeljko Strikić and Josip Žunić. "A restrictive dose of crystalloids in patients during laparoscopic cholecystectomy is safe and cost-effective: prospective, two-arm parallel, randomized controlled trial." Therapeutics and Clinical Risk Management 14 (2018): 741-745. https://doi.org/10.2147/TCRM.S160778

Belavić, M., et al. (2018) 'A restrictive dose of crystalloids in patients during laparoscopic cholecystectomy is safe and cost-effective: prospective, two-arm parallel, randomized controlled trial', Therapeutics and Clinical Risk Management, 14, pp. 741-745. doi: 10.2147/TCRM.S160778

Belavić M, Sotošek Tokmadžić V, Brozović Krijan A, Kvaternik I, Matijaš K, Strikić N, and sur.. A restrictive dose of crystalloids in patients during laparoscopic cholecystectomy is safe and cost-effective: prospective, two-arm parallel, randomized controlled trial. Therapeutics and Clinical Risk Management [Internet]. 2018 April [cited 2024 April 14];14:741-745. doi: 10.2147/TCRM.S160778

M. Belavić, et al., "A restrictive dose of crystalloids in patients during laparoscopic cholecystectomy is safe and cost-effective: prospective, two-arm parallel, randomized controlled trial", Therapeutics and Clinical Risk Management, vol. 14, pp. 741-745, April 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:441313. [Accessed: 14 April 2024]

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Metadata
Title (english)A restrictive dose of crystalloids in patients during laparoscopic cholecystectomy is safe and cost-effective: prospective, two-arm parallel, randomized controlled trial
AuthorMatija Belavić
AuthorVlatka Sotošek Tokmadžić
AuthorAntonija Brozović Krijan
AuthorInes Kvaternik
AuthorKristina Matijaš
AuthorNedjeljko Strikić
AuthorJosip Žunić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Abstract (english)
Purpose: There are no evidence-based guidelines for volume replacement during surgical procedures such as laparoscopic cholecystectomy. However, the administration of a restrictive volume of crystalloids could be more cost-effective and safe. This trial aimed to determine the effectiveness and safety of a restrictive regimen of crystalloids in patients during laparoscopic cholecystectomy by analyzing its cost-effectiveness and 1-year morbidity rate. Patients and methods: In this randomized, prospective study, patients were assigned to one of three groups based on the volume of fluid administered: the restrictive group received 1 mL/kg/hr, the low liberal group received 5 mL/kg/hr, and the high liberal group received 15 mL/kg/hr of Ringer’s solution intraoperatively. There were 40 patients in each group. Each patient’s hemodynamic parameters and laboratory values (arterial blood gas and lactate levels) were measured together with their consumption of crystalloids, volatile anesthetics, and analgesics. Results: Analysis of the hemodynamic and laboratory parameters revealed no signs of global hypoperfusion in any of the groups analyzed. There was no significant difference in the duration of surgery and anesthesia, but the consumption of crystalloids, volatile anesthetics, and opioids was significantly lower in the restrictive group, compared with the low and high liberal groups. Although there was no significant difference in the 1-year morbidity among the groups, heart failure was observed in one patient in the high liberal group in the early postoperative period. Conclusion: Restrictive fluid therapy during laparoscopic cholecystectomy is justified, safe, and more cost-effective than other options.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleTherapeutics and Clinical Risk Management
Numberingvol. 14, pp. 741-745
e-ISSN1178-203X
DOIhttps://doi.org/10.2147/TCRM.S160778
URN:NBNurn:nbn:hr:184:441313
Publication2018-04
Document URLhttps://doi.org/10.2147/TCRM.S160778
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) icon
Created on2018-05-07 15:35:04