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Scientific paper - Review paper
Debljina i mikrobiota
Medicus, 27 (2018), 1 Debljina i ...; 21-27. urn:nbn:hr:184:638279
Bokan, Maja; Hauser, Goran

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Bokan, M. & Hauser, G. (2018). Debljina i mikrobiota. Medicus, 27. (1 Debljina i ...), 21-27. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:638279

Bokan, Maja and Goran Hauser. "Debljina i mikrobiota." Medicus, vol. 27, no. 1 Debljina i ..., 2018, pp. 21-27. https://urn.nsk.hr/urn:nbn:hr:184:638279

Bokan, Maja and Goran Hauser. "Debljina i mikrobiota." Medicus 27, no. 1 Debljina i ... (2018): 21-27. https://urn.nsk.hr/urn:nbn:hr:184:638279

Bokan, M. and Hauser, G. (2018) 'Debljina i mikrobiota', Medicus, 27(1 Debljina i ...), pp. 21-27. Available at: https://urn.nsk.hr/urn:nbn:hr:184:638279 (Accessed 18 December 2024)

Bokan M, Hauser G. Debljina i mikrobiota. Medicus [Internet]. 2018 April 26 [cited 2024 December 18];27(1 Debljina i ...):21-27. Available at: https://urn.nsk.hr/urn:nbn:hr:184:638279

M. Bokan and G. Hauser, "Debljina i mikrobiota", Medicus, vol. 27, no. 1 Debljina i ..., pp. 21-27, April 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:638279. [Accessed: 18 December 2024]

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Metadata
Title (croatian)Debljina i mikrobiota
Title (english)Obesity and Gut Microbiota
AuthorMaja Bokan
AuthorGoran Hauser
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (croatian)
Crijevna mikrobiota jest pojam koji se odnosi na cijelu populaciju mikroorganizama što koloniziraju određeno mjesto u probavnom traktu i uključuje ne samo bakterije već i druge mikrobe kao što su gljive, arheje, virusi i protozoe. Zdrava crijevna mikrobiota uglavnom se sastoji od Phyla firmicutes i bacteroidetes. Crijevna mikrobiota i njezina uloga u etiologiji debljine novo je područje istraživanja kojim se pokušava objasniti višak akumulacije energije u pretilih osoba, a može biti i potencijalni cilj terapeutske manipulacije za smanjenje skladištenja energije domaćina. Nekoliko je mehanizama predloženo kako bi se objasnila uloga crijevne mikrobiote u etiologiji pretilosti kao što su produkcija kratkolančanih masnih kiselina, stimulacija hormona, kronična upala niskog stupnja i sinteza specifčnih lipoproteina. Dokazi iz pokusa na životinjama sugeriraju da bi primjena probiotika mogla smanjiti dobiveni udio masti kao odgovor na prehranu s visokim udjelom masti (HFD). Pokazalo se da dodatak probiotika s Lactobacillus curvatus HY7601, Lactobacillus plantarum KY1032, Pediococcus pentosaceus LP28 i Lactobacillus rhamnosus GG utječe na smanjenje nastanka masnog tkiva i količine triglicerida u plazmi uz povećanje osjetljivosti na inzulin. Dokazi iz životinjskih i humanih studija upućuju na prijepore u određivanju uzročno-posljedičnog odnosa između crijevne mikrobiote i pretilosti.
Abstract (english)
Gut microbiota refers to the entire population of microorganisms that colonize a specific location in the digestive tract. It includes not only bacteria, but also other microbes such as fungi, archaea, viruses and protozoa. Healthy gut microbiota comprises mostly of Phyla firmicutes and bacteroidetes. Gut microbiota and its role in the aetiology of obesity is a new area of research that is trying to explain the excess energy accumulation in obese people. Microbiota can also be a potential target of therapeutic manipulation aimed at reducing energy storage in the host. Several mechanisms have been proposed to explain the role of gut microbiota in the aetiology of obesity, including short-chain fatty acid production, hormone stimulation, chronic low-grade inZammation and specific lipoprotein synthesis. Evidence from animal testing suggests that the use of probiotics could reduce the amount of fat gained as a result of a high-fat diet (HFD). Probiotic supplements with Lactobacillus curvatus HY7601, Lactobacillus plantarum KY1032, Pediococcus pentosaceus LP28 and Lactobacillus rhamnosus GG have reduced adipose tissue accumulation and plasma triglyceride levels and have improved insulin sensitivity. Evidence from animal and human studies indicates controversies in determining the cause and eect relationship between gut microbiota and obesity.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicus
Numberingvol. 27, no. 1 Debljina i ..., pp. 21-27
p-ISSN1330-013X
e-ISSN1848-8315
URN:NBNurn:nbn:hr:184:638279
Publication2018-04-26
Document URLhttps://hrcak.srce.hr/199414
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2018-04-30 14:00:34