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master's thesis
KLINIČKE I LABORATORIJSKE RAZLIKE AKUTNOG PANKREATITISA NAKON ENDOSKOPSKE RETROGRADNE KOALNGIOPANKREATOGRAFIJE
2017. urn:nbn:hr:184:256703
Blažić, Filip
University of Rijeka
Faculty of Medicine
Department of Internal Medicine

Cite this document

Blažić, F. (2017). KLINIČKE I LABORATORIJSKE RAZLIKE AKUTNOG PANKREATITISA NAKON ENDOSKOPSKE RETROGRADNE KOALNGIOPANKREATOGRAFIJE (Master's thesis). Rijeka: University of Rijeka, Faculty of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:256703

Blažić, Filip. "KLINIČKE I LABORATORIJSKE RAZLIKE AKUTNOG PANKREATITISA NAKON ENDOSKOPSKE RETROGRADNE KOALNGIOPANKREATOGRAFIJE." Master's thesis, University of Rijeka, Faculty of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:184:256703

Blažić, Filip. "KLINIČKE I LABORATORIJSKE RAZLIKE AKUTNOG PANKREATITISA NAKON ENDOSKOPSKE RETROGRADNE KOALNGIOPANKREATOGRAFIJE." Master's thesis, University of Rijeka, Faculty of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:184:256703

Blažić, F. (2017). 'KLINIČKE I LABORATORIJSKE RAZLIKE AKUTNOG PANKREATITISA NAKON ENDOSKOPSKE RETROGRADNE KOALNGIOPANKREATOGRAFIJE', Master's thesis, University of Rijeka, Faculty of Medicine, accessed 04 December 2024, https://urn.nsk.hr/urn:nbn:hr:184:256703

Blažić F. KLINIČKE I LABORATORIJSKE RAZLIKE AKUTNOG PANKREATITISA NAKON ENDOSKOPSKE RETROGRADNE KOALNGIOPANKREATOGRAFIJE [Master's thesis]. Rijeka: University of Rijeka, Faculty of Medicine; 2017 [cited 2024 December 04] Available at: https://urn.nsk.hr/urn:nbn:hr:184:256703

F. Blažić, "KLINIČKE I LABORATORIJSKE RAZLIKE AKUTNOG PANKREATITISA NAKON ENDOSKOPSKE RETROGRADNE KOALNGIOPANKREATOGRAFIJE", Master's thesis, University of Rijeka, Faculty of Medicine, Rijeka, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:184:256703

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TitleKLINIČKE I LABORATORIJSKE RAZLIKE AKUTNOG PANKREATITISA NAKON ENDOSKOPSKE RETROGRADNE KOALNGIOPANKREATOGRAFIJE
Title (english)CLINICAL AND LABORATORY DIFFERENCES BETWEEN ACUTE PANCREATITIS AND POST ENDSCOPIC RETROGRADE CHOLANGIOPANCEATOGRAPHY PANCREATITIS
AuthorFilip Blažić
MentorGoran Hauser (mentor)
MentorVanja Licul (komentor)
Committee memberAlen Protić (predsjednik povjerenstva)
Committee memberSanja Klobučar-Majanović (član povjerenstva)
Committee memberBrankica Mijandrušić-Sinčić (član povjerenstva)
GranterUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Rijeka
Defense date and country2017-09-22, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Akutni pankreatitis (AP) je najčešća komplikacija endoskopske retrogradne kolangiopankreatografije, tj. post-ERCP pankreatitis (PEP), a javlja se u 5-10% slučajeva (9, 10) a ukupna incidencija teškog oblika bolesti sa nerijetko fatalnim posljedicama iznosi 0,5%. Nejasno je postojeće znanstveno razumijevanje imunoloških procesa koji se javljaju tijekom akutnog pankreatitisa (AP), bilo da je to uobičajena i najčešća etiologija (bilijarna ili alkoholna), ili kao komplikacija nakon endoskopske retrogradne kolangiopankreatografije (ERCP), odnosno post-ERCP pankreatitis (PEP). Ono što je najvažnije, naša intervencijska terapija je oskudna i nespecifična, nasuprot potencijalno mogućoj i željenoj ciljanoj imunomodulatornoj terapiji (14). Postoji potreba za otkrivanjem ciljanog najprikladnijeg markera ili sustava za rano predviđanje i otkrivanje teških oblika akutnog pankreatitisa (SAP). IL-6 i IL-8 kao mogući prediktori težine kliničke slike(14), a IL-22 kao potencijal u prevenciji PEP-a (34). Različiti klinički ishod ne-ERCP induciranih AP-a i PEP-a pronađen je u nekoliko studija (22-24). Postoji različitost kliničke slike između AP-a i PEP-a, odnosno prognoza teškog oblika PEP-a je lošija od teškog oblika AP-a. Blaži oblici PEP-a imaju bolju prognozu od blažih oblika AP-a druge etiologije (24).
Abstract (english)
Acute pancreatitis (AP) is the most common complication of endoscopic retrograde cholangiopancreatography, i.e. post-ERCP pancreatitis (PEP), with incidence of 5-10% (9, 10), with total incidence of severe forms of the disease in 0,5% of cases. We have a vague understanding of the immunological processes occurring during acute pancreatitis (AP), be it of usual and most common etiology (biliary or alcoholic), or post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). What matters most, our interceding therapeutic options are meager, with hopes of finding new immunological pathways for a more specific treatment (14) . There is a need to identify the most suitable marker or early anticipation and detection system for severe acute pancreatitis (SAP). IL-6 and IL-8 as possible predictors of severity of clinical prognosis (14) and IL-22 as potential in the prevention of PEP (34). Different clinical outcome of non-ERCP induced AP and PEP was found in several studies (22-24). Severe form of PEP has a rather worse clinical outcome than severe form of AP, but a mild form of PEP is a minor inconvenience with one or two days of added hospitalization with full recovery and better prognosis than AP of other etiology (24).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:184:256703
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2018-01-04 10:04:38