prikaz prve stranice dokumenta Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats
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Scientific paper - Original scientific paper
Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats
Histology and Histopathology, 32 (2017); 137-151. https://doi.org/10.14670/HH-11-780
Grubić Kezele, Tanja; Blagojević Zagorac, Gordana; Jakovac, Hrvoje; Domitrović, Robert; Radošević-Stašić, Biserka

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Grubić Kezele, T., Blagojević Zagorac, G., Jakovac, H., Domitrović, R. & Radošević Stašić, B. (2017). Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats. Histology and Histopathology, 32., 137-151. doi: 10.14670/HH-11-780

Grubić Kezele, Tanja, et al. "Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats." Histology and Histopathology, vol. 32, 2017, pp. 137-151. https://doi.org/10.14670/HH-11-780

Grubić Kezele, Tanja, Gordana Blagojević Zagorac, Hrvoje Jakovac, Robert Domitrović and Biserka Radošević Stašić. "Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats." Histology and Histopathology 32 (2017): 137-151. https://doi.org/10.14670/HH-11-780

Grubić Kezele, T., et al. (2017) 'Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats', Histology and Histopathology, 32, pp. 137-151. doi: 10.14670/HH-11-780

Grubić Kezele T, Blagojević Zagorac G, Jakovac H, Domitrović R, Radošević Stašić B. Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats. Histology and Histopathology [Internet]. 2017 [cited 2024 December 25];32:137-151. doi: 10.14670/HH-11-780

T. Grubić Kezele, G. Blagojević Zagorac, H. Jakovac, R. Domitrović and B. Radošević Stašić, "Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats", Histology and Histopathology, vol. 32, pp. 137-151, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:466957. [Accessed: 25 December 2024]

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Title (english)Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats
AuthorTanja Grubić Kezele
AuthorGordana Blagojević Zagorac
AuthorHrvoje Jakovac
AuthorRobert Domitrović
AuthorBiserka Radošević-Stašić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Inflammatory demyelinating diseases such as multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) are often followed by cognitive deficits associated with the neuronal injury, synaptic loss and altered neurogenesis within the hippocampus. Changes depend on the genetic and epigenetic factors that ensure the cellular and environmental homeostasis and regulate the interactions of immunocompetent, glial and neural cells. Owing to high impact of stress proteins on these processes, in this study we compared the protein content of interleukin-6, transforming growth factor-β1, metallothioneins I/II (MTs) and glycoprotein 96 (gp96) in the hippocampus of DA and AO rats that differ in the susceptibility to the induction of EAE, and tested the relationship of MTs and gp96 to granule neurons, glial cells and neural progenitors in different subfields of dentate gyrus. Rats were immunized with bovine brain homogenate emulsified in complete Freund's adjuvant or only with CFA. The data showed that acute attack of EAE in DA rats was followed by accumulation of IL-6, TGF-β1 and MTs proteins, by increased expression of MTs in molecular and granular cell layer, by reduced expression of gp96/granular cell, by apoptosis and by microgliosis with appearance of Iba-1+ cells, co-expressing MT I/II and gp96. Furthermore, in subgranular zone (SGZ) of DA rats an augmented number of GFAP+ precursors, but decreased number of doublecortin (DCX)+ neuroblasts and immature NeuN+ neurons were found, implying that in DA rats the neurogenesis was delayed or reduced. Besides, in SGZ of both strains several DCX+ and NeuN+ cells co-expressing gp96 and MT I/II were found.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleHistology and Histopathology
Numberingvol. 32, pp. 137-151
p-ISSN0213-3911
e-ISSN1699-5848
DOIhttps://doi.org/10.14670/HH-11-780
URN:NBNurn:nbn:hr:184:466957
Publication2017
Document URLhttps://www.ncbi.nlm.nih.gov/pubmed/27173051?dopt=Citation
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2017-09-21 07:39:59