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Professional paper - Review paper
Nitrati danas
Medicus, 19 (2010), 2_Kardiologija; 175-179. urn:nbn:hr:184:124733
Vitezić, Dinko; Mavrić, Žarko; Zaputović, Luka

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Vitezić, D., Mavrić, Ž. & Zaputović, L. (2010). Nitrati danas. Medicus, 19. (2_Kardiologija), 175-179. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:124733

Vitezić, Dinko, et al. "Nitrati danas." Medicus, vol. 19, no. 2_Kardiologija, 2010, pp. 175-179. https://urn.nsk.hr/urn:nbn:hr:184:124733

Vitezić, Dinko, Žarko Mavrić and Luka Zaputović. "Nitrati danas." Medicus 19, no. 2_Kardiologija (2010): 175-179. https://urn.nsk.hr/urn:nbn:hr:184:124733

Vitezić, D., Mavrić, Ž. and Zaputović, L. (2010) 'Nitrati danas', Medicus, 19(2_Kardiologija), pp. 175-179. Available at: https://urn.nsk.hr/urn:nbn:hr:184:124733 (Accessed 08 July 2024)

Vitezić D, Mavrić Ž, Zaputović L. Nitrati danas. Medicus [Internet]. 2010 December 11 [cited 2024 July 08];19(2_Kardiologija):175-179. Available at: https://urn.nsk.hr/urn:nbn:hr:184:124733

D. Vitezić, Ž. Mavrić and L. Zaputović, "Nitrati danas", Medicus, vol. 19, no. 2_Kardiologija, pp. 175-179, December 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:124733. [Accessed: 08 July 2024]

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Metadata
Title (croatian)Nitrati danas
Title (english)Nitrates Today
AuthorDinko Vitezić
AuthorŽarko Mavrić
AuthorLuka Zaputović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (croatian)
Organski nitrati, poput nitroglicerina, izosorbid dinitrata i izosorbid mononitrata, u medicinskoj su uporabi već više od 150 godina. Uobičajeno se rabe u liječenju kardiovaskularnih bolesti. Mehanizam djelovanja je u otpuštanju dušik (II) oksida u glatkim mišićnim stanicama stijenke krvnih žila i endotelnim stanicama nakon bioaktivacije. U konačnici to rezultira relaksacijom glatkih mišićnih stanica i drugim staničnim učincima. Osnovni čimbenik koji ograničava primjenu ove skupine lijekova je razvoj tolerancije. Osiguravanje razdoblja bez nitrata (niske koncentracije) najjednostavniji je i najprihvatljiviji način sprečavanja tolerancije. Karakteristične nuspojave nitrata jesu glavobolja, arterijska hipotenzija i sinkopa. Zaključno, organski su nitrati i dalje skupina vrlo učinkovitih protuishemijskih lijekova koji se rabe u liječenju bolesnika sa stabilnom anginom pektoris i akutnim koronarnim sindromom (nestabilnom anginom i akutnim infarktom miokarda).
Abstract (english)
Organic nitrates, such as nitroglycerin, isosorbide dinitrate and isosorbide mononitrate have been in medical use for more than 150 years. They are commonly used in therapy of cardiovascular diseases. Their mechanism of action lies in releasing nitric oxide in vascular smooth muscle cells and endothelial cells when bioactivated. This results finally in smooth muscle cell relaxation and other cellular effects. A major factor limiting the efficacy of these drugs is in the development of tolerance. Provision of a nitrate-free interval has taken on increasing significance as a strategy to avoid tolerance. Some typical side-effects of nitrates are headache, arterial hypotension and syncope. In conclusion, organic nitrates still represent a group of very effective anti-ischemic drugs used for the treatment of patients with stable angina pectoris and acute coronary syndrome (unstable angina and acute myocardial infarction).
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicus
Numberingvol. 19, no. 2_Kardiologija, pp. 175-179
p-ISSN1330-013X
e-ISSN1848-8315
URN:NBNurn:nbn:hr:184:124733
Publication2010-12-11
Document URLhttp://hrcak.srce.hr/65104
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-09-19 21:46:42