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Scientific paper - Original scientific paper
Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris
Collegium antropologicum, 32 - Supplement 2 (2008), 2; 53-56. urn:nbn:hr:184:088069
Čabrijan, Leo; Lipozenčić, Jasna; Batinac, Tanja; Lenković, Maja; Stanić Žgombić, Zrinka

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Čabrijan, L., Lipozenčić, J., Batinac, T., Lenković, M. & Stanić Žgombić, Z. (2008). Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris. Collegium antropologicum, 32 - Supplement 2. (2), 53-56. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:088069

Čabrijan, Leo, et al. "Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris." Collegium antropologicum, vol. 32 - Supplement 2, no. 2, 2008, pp. 53-56. https://urn.nsk.hr/urn:nbn:hr:184:088069

Čabrijan, Leo, Jasna Lipozenčić, Tanja Batinac, Maja Lenković and Zrinka Stanić Žgombić. "Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris." Collegium antropologicum 32 - Supplement 2, no. 2 (2008): 53-56. https://urn.nsk.hr/urn:nbn:hr:184:088069

Čabrijan, L., et al. (2008) 'Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris', Collegium antropologicum, 32 - Supplement 2(2), pp. 53-56. Available at: https://urn.nsk.hr/urn:nbn:hr:184:088069 (Accessed 04 May 2024)

Čabrijan L, Lipozenčić J, Batinac T, Lenković M, Stanić Žgombić Z. Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris. Collegium antropologicum [Internet]. 2008 October 01 [cited 2024 May 04];32 - Supplement 2(2):53-56. Available at: https://urn.nsk.hr/urn:nbn:hr:184:088069

L. Čabrijan, J. Lipozenčić, T. Batinac, M. Lenković and Z. Stanić Žgombić, "Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris", Collegium antropologicum, vol. 32 - Supplement 2, no. 2, pp. 53-56, October 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:088069. [Accessed: 04 May 2024]

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Title (english)Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris
AuthorLeo Čabrijan
AuthorJasna Lipozenčić
AuthorTanja Batinac
AuthorMaja Lenković
AuthorZrinka Stanić Žgombić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
The expression of adhesion molecules Intercellular adhesion molecule-1(ICAM-1) and Vascular cell adhesion molecule- 1 (VCAM-1) is increased in lesional and in non-lesional skin of psoriatic patients, and play role in pathogenesis of the disease. PUVA and UVB therapy are important treatments of psoriasis vulgaris. It has been demonstrated that UVA and UVB therapies reduce expression of these molecules. In this investigation, phototherapy was used to treat psoriatic patients. The expression of these molecules was examined by immunohistochemical method in lesional and non-lesional skin of 10 patients with psoriasis vulgaris before and after treatment. Results showed increased expression of ICAM-1 molecules in keratinocytes, in perivascular infiltrate – lymphocytes, and in endothelial cells. The expression of VCAM-1 molecules was also increased, although with less intensity then ICAM-1. After therapy, the expression of the adhesion molecules decreased together with a marked improvement of the disease. In conclusion, study demonstrated that phototherapy improves psoriasis vulgaris probably through mechanisms acting on the adhesions molecules. Adverse reactions due to intense or long lasting UVA (PUVA) and UVB therapies are immunosuppression and damage of DNA which can lead to development of non-melanocytic skin tumors like basal cell carcinoma and squamous cell carcinoma, as well as melanoma.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 32 - Supplement 2, no. 2, pp. 53-56
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:088069
Publication2008-10-01
Document URLhttp://hrcak.srce.hr/34540
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-09-17 18:53:40