prikaz prve stranice dokumenta Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis
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Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis
Collegium antropologicum, 31 - Supplement 1 (2007), 1; 83-85. urn:nbn:hr:184:784640
Prpić Massari, Larisa; Kaštelan, Marija; Gruber, Franjo

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Prpić Massari, L., Kaštelan, M. & Gruber, F. (2007). Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis. Collegium antropologicum, 31 - Supplement 1. (1), 83-85. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:784640

Prpić Massari, Larisa, et al. "Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis." Collegium antropologicum, vol. 31 - Supplement 1, no. 1, 2007, pp. 83-85. https://urn.nsk.hr/urn:nbn:hr:184:784640

Prpić Massari, Larisa, Marija Kaštelan and Franjo Gruber. "Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis." Collegium antropologicum 31 - Supplement 1, no. 1 (2007): 83-85. https://urn.nsk.hr/urn:nbn:hr:184:784640

Prpić Massari, L., Kaštelan, M. and Gruber, F. (2007) 'Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis', Collegium antropologicum, 31 - Supplement 1(1), pp. 83-85. Available at: https://urn.nsk.hr/urn:nbn:hr:184:784640 (Accessed 13 November 2024)

Prpić Massari L, Kaštelan M, Gruber F. Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis. Collegium antropologicum [Internet]. 2007 January 16 [cited 2024 November 13];31 - Supplement 1(1):83-85. Available at: https://urn.nsk.hr/urn:nbn:hr:184:784640

L. Prpić Massari, M. Kaštelan and F. Gruber, "Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis", Collegium antropologicum, vol. 31 - Supplement 1, no. 1, pp. 83-85, January 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:784640. [Accessed: 13 November 2024]

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Metadata
Title (english)Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis
AuthorLarisa Prpić Massari
AuthorMarija Kaštelan
AuthorFranjo Gruber
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
Basal cell carcinoma and squamous cell carcinoma, collectively termed non-melanoma skin cancers are the most commonmalignant tumors in humans. Basal cell carcinoma grows slowly and metastatic spread is very rare. Squamous cell carcinoma is characterized by infiltrative, destructive growth and metastasis. Long-term exposure of skin to UV light has a great impact on development of these epidermal malignancies. UV light induces cascade of events like well known DNA damage of keratinocytes as well as still completely undetermined influence on apoptotic process through expression of proapoptotic and antiapoptotic molecules. The major role in development of skin cancer is given to proapoptotic p53 molecule or tumor suppressor gene which mutation due to UV exposure leads to resistance of DNA-damaged cell to apoptosis. Other proapoptotic molecules such as Fas ligand (FasL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) are strongly expressed in basal cell carcinoma and squamous cell carcinoma that could be explained by the ability of tumor to escape the attack of immune system.
Keywords (english)
Languageenglish
Publication typeProfessional paper - Professional paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 31 - Supplement 1, no. 1, pp. 83-85
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:784640
Publication2007-01-16
Document URLhttp://hrcak.srce.hr/27430
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-08-08 11:22:18