prikaz prve stranice dokumenta Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion
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Scientific paper - Original scientific paper
Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion
Reproductive BioMedicine Online, 24 (2012), 5; 567-575. https://doi.org/10.1016/j.rbmo.2012.01.008
Pereza, Nina; Ostojić, Saša; Volk, Marija; Kapović, Miljenko; Peterlin, Borut

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Pereza, N., Ostojić, S., Volk, M., Kapović, M. & Peterlin, B. (2012). Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion. Reproductive BioMedicine Online, 24. (5), 567-575. doi: 10.1016/j.rbmo.2012.01.008

Pereza, Nina, et al. "Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion." Reproductive BioMedicine Online, vol. 24, no. 5, 2012, pp. 567-575. https://doi.org/10.1016/j.rbmo.2012.01.008

Pereza, Nina, Saša Ostojić, Marija Volk, Miljenko Kapović and Borut Peterlin. "Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion." Reproductive BioMedicine Online 24, no. 5 (2012): 567-575. https://doi.org/10.1016/j.rbmo.2012.01.008

Pereza, N., et al. (2012) 'Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion', Reproductive BioMedicine Online, 24(5), pp. 567-575. doi: 10.1016/j.rbmo.2012.01.008

Pereza N, Ostojić S, Volk M, Kapović M, Peterlin B. Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion. Reproductive BioMedicine Online [Internet]. 2012 [cited 2025 March 31];24(5):567-575. doi: 10.1016/j.rbmo.2012.01.008

N. Pereza, S. Ostojić, M. Volk, M. Kapović and B. Peterlin, "Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion", Reproductive BioMedicine Online, vol. 24, no. 5, pp. 567-575, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:246002. [Accessed: 31 March 2025]

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Metadata
Title (english)Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion
AuthorNina Pereza
AuthorSaša Ostojić
AuthorMarija Volk
AuthorMiljenko Kapović
AuthorBorut Peterlin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
ARTICLE Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion Nina Pereza a , Sas ˇ a Ostojic ́ a, * , Marija Volk b , Miljenko Kapovic ́ a , Borut Peterlin b a Department of Biology and Medical Genetics, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia; b Institute of Medical Genetics, Department of Gynaecology and Obstetrics, UMC Ljubljana, 1000 Ljubljana, ... More Slovenia * Corresponding author. E-mail address: sasa@medri.hr (S Ostojic ́). Nina Pereza, MD, is a PhD student at the Faculty of Medicine, University of Rijeka. She works at the Department of Biology and Medical Genetics and her main interest of research is reproductive genetics, especially genetic causes associated with idiopathic recurrent spontaneous abortion. Abstract Idiopathic recurrent spontaneous abortion (IRSA) has been associated with abnormalities in the remodelling of endome- trial extracellular matrix, as well as aberrant matrix metalloproteinase (MMP) gene expression in endometrium of IRSA women and chorionic villi of IRSA concepti. This study investigated the association of five functional MMP gene promoter polymorphisms (MMP1 1607 1G/2G, MMP2 735 C/T, MMP2 1306 C/T, MMP3 1612 5A/6A and MMP9 1562 C/T) with IRSA. A total of 149 couples with at least three consecutive IRSA and 149 fertile couples were included in a case–control study. Genotype analysis was performed using PCR restriction fragment length polymorphism. Statistically significant differences were found in distributions of MMP2 735 CT (chi-squared 10.21, P = 0.006; OR 2.15, 95% CI 1.34–3.45, P = 0.001), and MMP9 1562 CC (chi-squared 9.06, P = 0.010; OR 2.21, 95% CI 1.30–3.80, P = 0.004) between IRSA women and controls. Combined analysis of MMP gene polymorphisms did not increase their predictive value. There were no statistically significant differences in genotype and allele frequencies of any polymorphism between IRSA men and controls. MMP2 735 C/T and MMP9 1562 C/T functional gene polymorphisms might be associated with an increased risk of IRSA in women. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleReproductive BioMedicine Online
Numberingvol. 24, no. 5, pp. 567-575
p-ISSN1472-6483
DOIhttps://doi.org/10.1016/j.rbmo.2012.01.008
URN:NBNurn:nbn:hr:184:246002
Publication2012
Document URLhttps://doi.org/10.1016/j.rbmo.2012.01.008
Type of resourceText
Access conditionsInstitutional access
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Created on2017-07-31 11:04:58
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