prikaz prve stranice dokumenta Insertion/deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis
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Scientific paper - Original scientific paper
Insertion/deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis
Reproductive BioMedicine Online, 32 (2016), 2; 237-246. urn:nbn:hr:184:986315
Pereza, Nina; Ostojić, Saša; Zdravčević, Matea; Volk, Marija; Kapović, Miljenko; Peterlin, Borut

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Pereza, N., Ostojić, S., Zdravčević, M., Volk, M., Kapović, M. & Peterlin, B. (2016). Insertion/deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis. Reproductive BioMedicine Online, 32. (2), 237-246. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:986315

Pereza, Nina, et al. "Insertion/deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis." Reproductive BioMedicine Online, vol. 32, no. 2, 2016, pp. 237-246. https://urn.nsk.hr/urn:nbn:hr:184:986315

Pereza, Nina, Saša Ostojić, Matea Zdravčević, Marija Volk, Miljenko Kapović and Borut Peterlin. "Insertion/deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis." Reproductive BioMedicine Online 32, no. 2 (2016): 237-246. https://urn.nsk.hr/urn:nbn:hr:184:986315

Pereza, N., et al. (2016) 'Insertion/deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis', Reproductive BioMedicine Online, 32(2), pp. 237-246. Available at: https://urn.nsk.hr/urn:nbn:hr:184:986315 (Accessed 11 December 2024)

Pereza N, Ostojić S, Zdravčević M, Volk M, Kapović M, Peterlin B. Insertion/deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis. Reproductive BioMedicine Online [Internet]. 2016 [cited 2024 December 11];32(2):237-246. Available at: https://urn.nsk.hr/urn:nbn:hr:184:986315

N. Pereza, S. Ostojić, M. Zdravčević, M. Volk, M. Kapović and B. Peterlin, "Insertion/deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis", Reproductive BioMedicine Online, vol. 32, no. 2, pp. 237-246, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:986315. [Accessed: 11 December 2024]

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Metadata
Title (english)Insertion/deletion polymorphism in intron 16 of ACE gene in idiopathic recurrent spontaneous abortion: case-control study, systematic review and meta-analysis
AuthorNina Pereza
AuthorSaša Ostojić
AuthorMatea Zdravčević
AuthorMarija Volk
AuthorMiljenko Kapović
AuthorBorut Peterlin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
Abstract The insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin I-converting enzyme gene ( ACE ) has been ex- tensively studied as a predisposing factor for idiopathic recurrent spontaneous abortion (IRSA). A case-control study including 149 women with ≥ 3 spontaneous abortions and 149 controls was performed to test the association of ACE I/D polymorphism with IRSA. A systematic review was conducted of previous case-control studies, with strict selection criteria for meta-analyses. We also aimed to evaluate the potential differences in summary estimates between studies defining IRSA as ≥ 2 and ≥ 3 spontaneous abortions. Genotyping was performed by PCR, and systematic review conducted using PubMed and Scopus. There was no association of the polymorphism with IRSA in Slovenian women. Sixteen case-control studies, showing substantial differences regarding IRSA definition and selection criteria for women were identified. Meta-analysis was performed and included four studies defining IRSA as ≥ 2 spontaneous abor- tions and the current study, which defined IRSA as ≥ 3 spontaneous abortions. Based on random effects model, meta-analysis con- ducted on 1192 patients and 736 controls showed no association with IRSA under dominant (DD + IDvsII) and recessive (DDvsID + II) genetic models. Well-designed studies are needed to evaluate the role of ACE I/D polymorphism in IRSA defined as ≥ 3 spontaneous abortions
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleReproductive BioMedicine Online
Numberingvol. 32, no. 2, pp. 237-246
p-ISSN1472-6483
URN:NBNurn:nbn:hr:184:986315
Publication2016
Document URLhttp://dx.doi.org/10.1016/j.rbmo.2015.11.003
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2017-07-31 10:49:41