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NAŠA ISKUSTVA S PRIMJENOM CEFEPIMA U LIJEČENJU HOSPITALIZIRANE DJECE S DOMICILNOM PNEUMONIJOM
Medicina, 39 (2003), 1; 17-20. urn:nbn:hr:184:143384
Banac, Srđan; Ahel, Vladimir; Rožmanić, Vojko; Čače, Neven; Palčevski, Goran

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Banac, S., Ahel, V., Rožmanić, V., Čače, N. & Palčevski, G. (2003). NAŠA ISKUSTVA S PRIMJENOM CEFEPIMA U LIJEČENJU HOSPITALIZIRANE DJECE S DOMICILNOM PNEUMONIJOM. Medicina, 39. (1), 17-20. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:143384

Banac, Srđan, et al. "NAŠA ISKUSTVA S PRIMJENOM CEFEPIMA U LIJEČENJU HOSPITALIZIRANE DJECE S DOMICILNOM PNEUMONIJOM." Medicina, vol. 39, no. 1, 2003, pp. 17-20. https://urn.nsk.hr/urn:nbn:hr:184:143384

Banac, Srđan, Vladimir Ahel, Vojko Rožmanić, Neven Čače and Goran Palčevski. "NAŠA ISKUSTVA S PRIMJENOM CEFEPIMA U LIJEČENJU HOSPITALIZIRANE DJECE S DOMICILNOM PNEUMONIJOM." Medicina 39, no. 1 (2003): 17-20. https://urn.nsk.hr/urn:nbn:hr:184:143384

Banac, S., et al. (2003) 'NAŠA ISKUSTVA S PRIMJENOM CEFEPIMA U LIJEČENJU HOSPITALIZIRANE DJECE S DOMICILNOM PNEUMONIJOM', Medicina, 39(1), pp. 17-20. Available at: https://urn.nsk.hr/urn:nbn:hr:184:143384 (Accessed 12 November 2024)

Banac S, Ahel V, Rožmanić V, Čače N, Palčevski G. NAŠA ISKUSTVA S PRIMJENOM CEFEPIMA U LIJEČENJU HOSPITALIZIRANE DJECE S DOMICILNOM PNEUMONIJOM. Medicina [Internet]. 2003 [cited 2024 November 12];39(1):17-20. Available at: https://urn.nsk.hr/urn:nbn:hr:184:143384

S. Banac, V. Ahel, V. Rožmanić, N. Čače and G. Palčevski, "NAŠA ISKUSTVA S PRIMJENOM CEFEPIMA U LIJEČENJU HOSPITALIZIRANE DJECE S DOMICILNOM PNEUMONIJOM", Medicina, vol. 39, no. 1, pp. 17-20, 2003. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:143384. [Accessed: 12 November 2024]

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Title (croatian)NAŠA ISKUSTVA S PRIMJENOM CEFEPIMA U LIJEČENJU HOSPITALIZIRANE DJECE S DOMICILNOM PNEUMONIJOM
Title (english)OUR EXPERIENCES WITH CEFEPIME IN THE TREATMENT OF HOSPITALISED CHILDREN WITH COMMUNITY-ACQUIRED PNEUMONIA
AuthorSrđan Banac
AuthorVladimir Ahel
AuthorVojko Rožmanić
AuthorNeven Čače
AuthorGoran Palčevski
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pediatrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Abstract (croatian)
Uvod. Publicirana zapažanja i iskustva o kliničkoj primjeni cefepima, cefalosporina četvrte generacije, u djece s pneumonijom su oskudna. Cilj rada. Iznijeti iskustva primjene cefepima u bolnički liječene djece s ozbiljnom kliniËčom slikom tipične domicilne pneumonije. Metode. Cefepim je korišten u liječenju osam dječaka i tri djevojčice srednje dobi od 6,5 godina, uz raspon dobi od 4 do 14 godina zbog domicilne pneumonije. Svi su bolesnici prethodno neuspje no ambulantno liječeni peroralnim antibioticima. Cefepim je primjenjivan u obliku kratkotrajne intravenske infuzije, dvaput na dan, u pojedinačnoj dozi od 50 mg/kg (maksimalno 1 g) tijekom sedam dana. Rezultati. Desetero bolesnika (91%) imalo je dobar klinički odgovor na liječenje, popraćen značajnim padom vrijednosti reaktanata akutne faze upale i normalizacijom nalaza bijele krvne slike. U jednog djeteta došlo je do razvoja manjega pleuralnog izljeva pa je u liječenje uveden vankomicin. Djeca nisu imala simptome niti su pokazivala znakove koje bi mogli pripisati kakvoj ozbiljnoj nuspojavi lijeka. Zabilježen je statistički značajan (p<0,05), blaæi porast funkcionalnih jetrenih proba. Zaključak. Naša iskustva upućuju na dobru učinkovitost cefepima u empirijskom liječenju hospitalizirane djece s ozbiljnom domicilnom pneumonijom. Iako se lijek pokazao dobro podnošljivim i sigurnim. Nakon provedenog liječenja potrebno je kontrolirati serumske razine jetrenih enzima.
Abstract (english)
Introduction. Publicised data about clinical use of cefepime, a fourth generation cephalosporin, in children with pneumonia are modest. Aim. To show our experiences with cefepime in the treatment of hospitalised children with serious community acquired pneumonia. Methods. Eight boys and 3 girls (mean age 6.5 years; span 4-14) were hospitalised and were treated with cefepime because of serious domicile pneumonia. All children were unsuccessfully treated with oral antibiotics prior to hospitalisation. Cefepim was administered as a rapid intravenous infusion, twice daily, during 7 days. Single dose was 50 mg/kg (max. 1 g). Results. Ten patients (91%) showed good clinical response characterised by significant decrease of acute-phase reactants and by normalisation of white blood cell count. The development of a smaller pleural effusion was detected in one child whom vancomycin was introduced into treatment. Children had nor symptoms nor signs which could be defined as serious adverse reactions to drug. However, statistically significant (p<0,05), mild increase of liver enzymes levels was noticed. Conclusion. Our experiences showed very good effectiveness of cefepime in the treatment of hospitalised children with serious community acquired pneumonia. Although cefepime appeared to be well tolerated and safe, we suggest that liver enzymes levels should be controled after the treatment is completed.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Professional paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina
Numberingvol. 39, no. 1, pp. 17-20
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:143384
Publication2003
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-06-06 11:48:06