master's thesis
HUMANI MIKROBIOM I KRONIČNE BOLESTI U DJECE

Mateo Madunić (2015)
Sveučilište u Rijeci
Medicinski fakultet
Metadata
TitleHUMANI MIKROBIOM I KRONIČNE BOLESTI U DJECE
AuthorMateo Madunić
Mentor(s)Vojko Rožmanić (thesis advisor)
Abstract
Ako uzmemo u obzir koliko bakterija nastanjuje naš organizam, vrlo je jednostavno zaključiti da one igraju važnu ulogu u njegovu razvoju i funkcijama. Bakterije sudjeluju u metaboličkim, fiziološkim i imunološkim funkcijama, tako da poremećaj sastava mikrobiote dovodi do poremećaja tih funkcija, odnosno do razvoja raznih bolesti. Probiotici su u brojnim studijama pokazali povoljno djelovanje na neke dječje bolesti. Uglavnom su to bolesti gastrointestinalnog sustava, kao što su nekrotizirajući enterokolitis, sindrom iritabilnog kolona, i akutni gastroenteritis. Postoje i mnoge bolesti dječje dobi kod kojih su istraživanja pokazala moguću ulogu mikrobiote u razvoju, međutim nedostaju kvalitetne studije koje bi dokazale djelotvornost probiotika u njihovoj prevenciji. Neke od njih jesu alergijske bolesti kao što su atopijski dermatitis i astma, metaboličke, kao što je pretilost, autoimune poput dijabetesa mellitusa tipa 1, te neurorazvojne bolesti, kao što je autizam. Naša znanja o funkcijama mikrobiote brzo napreduju, te se otkriva puno novih bolesti kojima bi disbioza bakterija mogla biti okidač za razvoj. Nove tehnologije su nam omogućile da možemo odrediti količinu bakterija u našem organizmu, kao i prepoznati većinu bakterijskih vrsta koje se nalaze u ljudskom tijelu. Također, pomoću novih tehnika karakteriziranja mikrobiote možemo odrediti i funkcionalni kapacitet bakterija. Ipak, iako naša znanja brzo napreduju, postoji još mnogo rupa u poznavanju funkcionalnog kapaciteta mikrobioma, koje tek trebamo popuniti.
Keywordsmicrobiome microbiota allergic diseases diabetes mellitus type 1 obesity autism
Committee MembersSrđan Banac
Mladen Peršić
Brigita Tićac
GranterSveučilište u Rijeci
Medicinski fakultet
PlaceRijeka
StateCroatia
Scientific field, discipline, subdisciplineBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pediatrics
Study programme typeuniversity
Study levelintegrated undergraduate and graduate
Study programmeMedicine
Academic title abbreviationdr. med.
Genremaster's thesis
Language Croatian
Defense date2015-06-25
Parallel abstract (English)
If we consider how many bacteria inhabit our organism , it is easy to conclude that they play an important role in its development and functions. The bacteria are involved in the metabolic, physiological and immunological functions, so disorder of the microbiota composition leads to disruption of these functions, or to the development of various diseases . Probiotics have shown beneficial effects in numerous studies, on some children's diseases . These are mostly diseases of the gastrointestinal system, such as necrotizing enterocolitis, irritable bowel syndrome , and acute gastroenteritis. There are also many childhood diseases for which studies have shown the possible role of microbiota in the development, but there is lack of quality studies to prove the efficacy of probiotics in the prevention of these diseases. Some of them are the allergic diseases, such as atopic dermatitis and asthma, metabolic, such as obesity, autoimmune, such as diabetes mellitus type 1 and neurodevelopmental diseases such as autism. Our knowledge about the functions of microbiota is rapidly progressing, and a lot of new diseases for whose development dysbiosis of bacteria may be a trigger, are discovered. New technologies have enabled us to determine the amount of bacteria in our bodies , as well as to recognize most of the bacterial species that we can found in the human body. Also, using new techniques to characterize the microbiota we can determine the functional capacity of bacteria. However , although our knowledge is making rapid progress, there are still many gaps in knowing the functional capacity of the microbiome, which need to be filled.
Parallel keywords (Croatian)mikrobiom mikrobiota atopijske bolesti pretilost dijabetes mellitus tip 1 autizam
Resource typetext
Access conditionAccess restricted to students and staff of home institution
Terms of usehttp://rightsstatements.org/vocab/InC/1.0/
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:750316
CommitterBosa Licul