Professional paper - Professional paper
QUALITY OF NON-STEROID ANTI-INFLAMMATORY DRUGS (NSAIDs) UTILIZATION IN PRIMARY CARE IN RIJEKA

Vlahović - Palčevski, Vera (2002)
Metadata
Language Croatian
Title (Croatian)KVALITETA PROPISIVANJA NESTEROIDNIH ANTIREUMATIKA (NSAR) U OPĆOJ PRAKSI U RIJECI
Title (English)QUALITY OF NON-STEROID ANTI-INFLAMMATORY DRUGS (NSAIDs) UTILIZATION IN PRIMARY CARE IN RIJEKA
AuthorVlahović - Palčevski, Vera
Abstract (Croatian)
Uvod. Nesteroidni antireumatici (NSAR) lijekovi su koji su najčešći uzroËnici nuspojava, uglavnom dispepsije i krvarenja iz gastrointestinalnog (GI) trakta. U ovom je radu analizirana potrošnja NSAR-a na recept u Rijeci u prvih šest mjeseci 2000., uzimajući u obzir njihovu GI toksičnost. Metode. Potrošnja NSAR-a izražena je brojem definiranih dnevnih doza (DDD) na 1000 stanovnika dnevno. Radi ocjene kvalitete propisivanja ovih lijekova, odreðen je segment DU90%. Unutar DU90% segmenta utvrðen je omjer potrošnje NSAR-a s visokim potencijalom za nastanak GI nuspojava (ketoprofen, piroksikam), niskim rizikom (ibuprofen, diklofenak) i srednjim ili neutvrðenim rizikom. Rezultati. U Rijeci je svakog dana bilo propisano 14 DDD/1000 stanovnika NSAR-a. Najviše je bio propisivan diklofenak (55%). Unutar DU90% segmenta bili su ibuprofen i diklofenak, ali i 21% piroksikama. Zaključak. Razmjerno visok postotak potrošnje NSAR-a s visokim rizikom za nastanak gastrointestinalnih nuspojava, upućuje na to da u Rijeci “medicina temeljena na dokazima” (evidence based medicine) nije imala ključnu ulogu u propisivanju ovih lijekova. Budući da, što se djelotvornosti tiče, meðu NSARima nema veće razlike, pri odabiru NSAR-a trebalo bi voditi računa o njihovom potencijalu za nastanak nuspojava i cijeni.
Abstract (English)
Introduction. Non-steroidal anti-inflamatory drugs (NSAIDs) are one of the most common causes of adverse drug reactions, notably dyspepsia and bleeding. In this study NSAIDs utilization pattern was assesed during the first six months of 2000, considering its gastrointestinal (GI) toxicity. Methods. NSAIDs utilization was measured as a number of defined daily doses (DDDs) per 1000 inhab/day. To determine the prescribing quality, NSAIDs utilization accounting for 90% of the use (DU90% segment) was determined. Within the DU90% segment, the proportion of «high riskfl (ketoprofen, piroxicam), «low riskfl (diclofenac, ibuprofen) and «intermediate riskfl (or no documentation) drugs regarding GI toxicity was evaluated. Results. In Rijeka, 14 DDD/1000 inhab/day of NSAIDs were prescribed. The most often prescribed NSAID was diclofenac with 55%. Three NSAIDs were found in the DU90% segment including diclofenac and ibuprofen. Within the DU 90% segment there was 21% of «high riskfl classified NSAIDs prescribed. Concusion. This study suggests that evidence-based medicine was not the leading impact factor in prescribing NSAIDs in Rijeka. Since no important diferences regarding efficacy exist among NSAIDs, the ultimate choice should depend on their relative toxicity and cost. Resuts of this study could be used as a basis for preparing prescription guidelines.
Keywords (Croatian)nesteroidni antireumatici, potro¹nja, opÊa praksa
Keywords (English)non-steroid anti-inflammatory, utilization, primary eare
Publication typeprofessional paper - professional paper
Publication statuspublished
Peer reviewpeer review
Journal titleMedicina
Numbering2002, Vol. 28, No. 3-4, pp 66-68
ISSN0025-7729
Datepublication: 2002.
Scientific fieldBIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Pharmacology and Toxicology
InstitutionUniversity of Rijeka, Faculty of Medicine
(Department of Pharmacology)
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:184:554839