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Professional paper - Review paper
Patogenetski mehanizmi u reumatoidnom artritisu
Medicina Fluminensis : Medicina Fluminensis, 48 (2012), 4; 403-414. urn:nbn:hr:184:732767
Ravlić-Gulan, Jagoda; Novak, Srđan; Gulan, Gordan

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Ravlić Gulan, J., Novak, S. & Gulan, G. (2012). Patogenetski mehanizmi u reumatoidnom artritisu. Medicina Fluminensis : Medicina Fluminensis, 48. (4), 403-414. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:732767

Ravlić Gulan, Jagoda, et al. "Patogenetski mehanizmi u reumatoidnom artritisu." Medicina Fluminensis : Medicina Fluminensis, vol. 48, no. 4, 2012, pp. 403-414. https://urn.nsk.hr/urn:nbn:hr:184:732767

Ravlić Gulan, Jagoda, Srđan Novak and Gordan Gulan. "Patogenetski mehanizmi u reumatoidnom artritisu." Medicina Fluminensis : Medicina Fluminensis 48, no. 4 (2012): 403-414. https://urn.nsk.hr/urn:nbn:hr:184:732767

Ravlić Gulan, J., Novak, S. and Gulan, G. (2012) 'Patogenetski mehanizmi u reumatoidnom artritisu', Medicina Fluminensis : Medicina Fluminensis, 48(4), pp. 403-414. Available at: https://urn.nsk.hr/urn:nbn:hr:184:732767 (Accessed 26 December 2024)

Ravlić Gulan J, Novak S, Gulan G. Patogenetski mehanizmi u reumatoidnom artritisu. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2012 December 03 [cited 2024 December 26];48(4):403-414. Available at: https://urn.nsk.hr/urn:nbn:hr:184:732767

J. Ravlić Gulan, S. Novak and G. Gulan, "Patogenetski mehanizmi u reumatoidnom artritisu", Medicina Fluminensis : Medicina Fluminensis, vol. 48, no. 4, pp. 403-414, December 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:732767. [Accessed: 26 December 2024]

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Metadata
Title (croatian)Patogenetski mehanizmi u reumatoidnom artritisu
Title (english)The pathogenic mechanisms in rheumatoid arthritis
AuthorJagoda Ravlić-Gulan
AuthorSrđan Novak
AuthorGordan Gulan
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathophysiology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Orthopedics
Abstract (croatian)
Reumatoidni artritis (RA) jedna je od najčešćih i najtežih autoimunih i kroničnih upalnih bolesti koja dovodi do ireverzibilnih oštećenja zglobova i sistemskih oštećenja ostalih organa, te uzrokuje tešku invalidnost i velik stupanj mortaliteta. Opisani su brojni patogenetski mehanizmi uključeni u nastanak i razvoj reumatoidnog artritisa, no etiologija bolesti još nije poznata. Međudjelovanje genetskih i čimbenika okoline izaziva gubitak tolerancije i javljanje autoimunog odgovora na vlastite antigene, što se manifestira razvojem artritisa i sistemskim poremećajima. Razjašnjavanje ranih patogenetskih mehanizama i složenih međustaničnih interakcija u sinovijalnoj membrani stvara uvjete za pronalazak dobrih i visokospecifičnih biomarkera za postavljanje rane dijagnoze, davanje prognoze i praćenje terapijskog odgovora, a time i za individualiziran pristup terapiji RA bolesnika, koji bi se temeljio na izravnom blokiranju ključnog patogenetskog mehanizma bolesti i indukciji tolerancije, a ne na supresiji imunološkog odgovora.
Abstract (english)
Rheumatoid arthritis (RA) is one of the most common and most severe autoimmune and chronic inflammatory disease leading to irreversible joint damage and systemic disorders of other organs that causes severe functional disability and higher rates of mortality. Many pathogenetic mechanisms involved in the induction and maintenance of rheumatoid arthritis are described, however, the etiology of the disease is not yet known. Interaction of genetic and environmental factors causes the loss of immune tolerance leading to autoimmune responses to self antigens, development of arthritis and systemic disorders. The identification of the early pathogenetic mechanisms and complex cellular interactions in the synovial membrane would provide conditions for finding a good and highly specific biomarkers for an early diagnosis, prognosis and therapeutic response, and thus for an individualized approach to treatment of RA patients, which would be based on direct blocking of the key pathogenetic mechanism of the disease and the induction of tolerance, rather than suppression of the immune responses.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 48, no. 4, pp. 403-414
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:732767
Publication2012-12-03
Document URLhttp://hrcak.srce.hr/95726
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-12 07:32:49