MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES
 II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation

Saalmüller, Armin; Jonjić, Stipan; Bühring, Hans-Jörg; Reddehase, Matthias J.; Koszinowski, Ulrich H.

prikaz prve stranice dokumenta MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation

Scientific paper - Original scientific paper

MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation

Journal of Immunology, 138 (1987), 6; 1852-1857. urn:nbn:hr:184:924665

Saalmüller, Armin; Jonjić, Stipan; Bühring, Hans-Jörg; Reddehase, Matthias J.; Koszinowski, Ulrich H.

Cite this document

APA 6th Edition

Saalmüller, A., Jonjić, S., Bühring, H. J., Reddehase, M. J. & Koszinowski, U. H. (1987). MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation. Journal of Immunology, 138. (6), 1852-1857. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:924665

MLA 8th Edition

Saalmüller, Armin, et al. "MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation." Journal of Immunology, vol. 138, no. 6, 1987, pp. 1852-1857. https://urn.nsk.hr/urn:nbn:hr:184:924665

Chicago 17th Edition

Saalmüller, Armin, Stipan Jonjić, Hans Jörg Bühring, Matthias J. Reddehase and Ulrich H. Koszinowski. "MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation." Journal of Immunology 138, no. 6 (1987): 1852-1857. https://urn.nsk.hr/urn:nbn:hr:184:924665

Harvard

Saalmüller, A., et al. (1987) 'MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation', Journal of Immunology, 138(6), pp. 1852-1857. Available at: https://urn.nsk.hr/urn:nbn:hr:184:924665 (Accessed 06 May 2024)

Vancouver

Saalmüller A, Jonjić S, Bühring HJ, Reddehase MJ, Koszinowski UH. MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation. Journal of Immunology [Internet]. 1987 [cited 2024 May 06];138(6):1852-1857. Available at: https://urn.nsk.hr/urn:nbn:hr:184:924665

IEEE

A. Saalmüller, S. Jonjić, H. J. Bühring, M. J. Reddehase and U. H. Koszinowski, "MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation", Journal of Immunology, vol. 138, no. 6, pp. 1852-1857, 1987. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:924665. [Accessed: 06 May 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:184:924665

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Metadata

Title (english)	MONOCLONAL ANTIBODIES REACTIVE WITH SWINE LYMPHOCYTES II. Detection of an Antigen on Resting T Cells Down-Regulated After Activation
Author	Armin Saalmüller
Author	Stipan Jonjić
Author	Hans-Jörg Bühring
Author	Matthias J. Reddehase
Author	Ulrich H. Koszinowski
Author's institution	University of Rijeka Faculty of Medicine (Department of Histology and Embryology)
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Basic Medical Sciences
Abstract (english)	The expression of an antigen on porcine T lymphocytes detected by murine monoclonal antibody (mAb) 8/1 was investigated by functional studies and dual-parameter immunofluorescence. mAb 8/1 reacts with greater than 95% of thymocytes and in peripheral blood with all T lymphocytes and with cells of the monocyte/macrophage lineage, but not with B cells, erythrocytes, and platelets. Pretreatment of peripheral blood lymphocytes with mAb 8/1 plus complement abrogated the proliferative response in vitro to mitogen, soluble antigen, and MHC determinants. Dual-parameter immunofluorescence revealed that resting porcine T8+ as well as T4+ lymphocytes express the 8/1 antigen, whereas after in vitro activation, cell surface expression of the antigen was low or absent in both T cell subsets. Thus, the 8/1 antigen represents a marker that discriminates between resting and activated T lymphocytes. Distribution and functional criteria indicate that 8/1 represents a novel marker not described before for any other mammalian species.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review - international
Publication version	Published version
Journal title	Journal of Immunology
Numbering	vol. 138, no. 6, pp. 1852-1857
p-ISSN	0022-1767
e-ISSN	1550-6606
URN:NBN	urn:nbn:hr:184:924665
Publication	1987
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2019-04-08 13:59:18