prikaz prve stranice dokumenta Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases
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Scientific paper - Original scientific paper
Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases
Croatian Medical Journal, 60 (2019), 1; 20-25. https://doi.org/10.3325/cmj.2019.60.20
Šegulja, Silvije; Ružić, Alen; Dujmić, Dora; Baždarić, Ksenija; Roganović, Jelena

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Šegulja, S., Ružić, A., Dujmić, D., Baždarić, K. & Roganović, J. (2019). Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases. Croatian Medical Journal, 60. (1), 20-25. doi: 10.3325/cmj.2019.60.20

Šegulja, Silvije, et al. "Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases." Croatian Medical Journal, vol. 60, no. 1, 2019, pp. 20-25. https://doi.org/10.3325/cmj.2019.60.20

Šegulja, Silvije, Alen Ružić, Dora Dujmić, Ksenija Baždarić and Jelena Roganović. "Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases." Croatian Medical Journal 60, no. 1 (2019): 20-25. https://doi.org/10.3325/cmj.2019.60.20

Šegulja, S., et al. (2019) 'Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases', Croatian Medical Journal, 60(1), pp. 20-25. doi: 10.3325/cmj.2019.60.20

Šegulja S, Ružić A, Dujmić D, Baždarić K, Roganović J. Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases. Croatian Medical Journal [Internet]. 2019 February [cited 2024 April 27];60(1):20-25. doi: 10.3325/cmj.2019.60.20

S. Šegulja, A. Ružić, D. Dujmić, K. Baždarić and J. Roganović, "Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases", Croatian Medical Journal, vol. 60, no. 1, pp. 20-25, February 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:306862. [Accessed: 27 April 2024]

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Metadata
Title (english)Simple predictors of the re- occurrence of severe febrile neutropenia episode: a single-center retrospective cohort study in pediatric patients with malignant diseases
AuthorSilvije Šegulja
AuthorAlen Ružić
AuthorDora Dujmić
AuthorKsenija Baždarić
AuthorJelena Roganović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Medical Informatics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Aim To identify the risk factors of a repeated episode of severe febrile neutropenia (FN) and to build an accurate and easy-to-use predictive model. Methods This single-center retrospective cohort study conducted at the Clinical Hospital Center Children’s Hospital Rijeka from January 1, 2008 to December 31, 2016 included pediatric patients with malignant diseases who experienced at least one FN episode. The association of the second severe FN episode appearance with relevant clinical and laboratory data was analyzed by logistic regression. Results Out of 45 patients with one FN episode, 25 (56%) had severe FN and 11 (24%) had repeated severe FNs. Significant predictors of a repeated severe FN episode were the first FN episode duration of 9 or more days and red blood cells ≤3.0 × 1012/L. The predictive model constructed by crossing these two indicators had the accuracy of 87% (95% confidence interval [CI] 73%-94%), sensitivity of 82% (95% CI 53%-97%), and specificity of 88% (95% CI 79%-93%). Conclusion The first FN episode duration and anemia are significantly associated with the risk for severe FN re-occurrence. These factors may be useful in the identification of children with cancer who are at high risk for adverse outcome at any future fever onset and may benefit from early intensive treatment.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 60, no. 1, pp. 20-25
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2019.60.20
URN:NBNurn:nbn:hr:184:306862
Publication2019-02
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406065/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2019-04-03 15:23:16