prikaz prve stranice dokumenta Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes
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Scientific paper - Original scientific paper
Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes
Journal of Experimental Medicine, 169 (1989), 4; 1199-1212. https://doi.org/10.1084/jem.169.4.1199
Jonjić, Stipan; Mutter, W.; Weiland, F.; Reddehase, MJ.; Koszinowski, U H.

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Jonjić, S., Mutter, W., Weiland, F., Reddehase, M. & Koszinowski, U. H. (1989). Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes. Journal of Experimental Medicine, 169. (4), 1199-1212. doi: 10.1084/jem.169.4.1199

Jonjić, Stipan, et al. "Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes." Journal of Experimental Medicine, vol. 169, no. 4, 1989, pp. 1199-1212. https://doi.org/10.1084/jem.169.4.1199

Jonjić, Stipan, W. Mutter, F. Weiland, MJ. Reddehase and U H. Koszinowski. "Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes." Journal of Experimental Medicine 169, no. 4 (1989): 1199-1212. https://doi.org/10.1084/jem.169.4.1199

Jonjić, S., et al. (1989) 'Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes', Journal of Experimental Medicine, 169(4), pp. 1199-1212. doi: 10.1084/jem.169.4.1199

Jonjić S, Mutter W, Weiland F, Reddehase M, Koszinowski UH. Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes. Journal of Experimental Medicine [Internet]. 1989 April 01 [cited 2024 May 13];169(4):1199-1212. doi: 10.1084/jem.169.4.1199

S. Jonjić, W. Mutter, F. Weiland, M. Reddehase and U. H. Koszinowski, "Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes", Journal of Experimental Medicine, vol. 169, no. 4, pp. 1199-1212, April 1989. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:885593. [Accessed: 13 May 2024]

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Metadata
Title (english)Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes
AuthorStipan Jonjić
AuthorW. Mutter
AuthorF. Weiland
AuthorMJ. Reddehase
AuthorU H. Koszinowski
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings. First, an antiviral response of the CD8 subset of T lymphocytes could be not only initiated but also maintained for a long period of time despite a continued absence of the CD4 subset, whereas the production of antiviral antibody proved strictly dependent upon help provided by the CD4 subset. Second, no function in the defense against infection could be ascribed as yet to CD4-CD8- T lymphocytes, which were seen to accumulate to a new subset as a result of depletion of the CD4 subset. This newly arising subset did not substitute for CD4+ T lymphocytes in providing help to B lymphocytes, and was also not effective in controlling the spread of virus in host tissues. As long as a function of these cells in the generation and maintenance of a CD8 subset-mediated response is not disproved, caution is indicated with concern to an autonomy of the CD8 subset. Third, even though with delay, the CD8+ effector cells raised in the CD4 subset-deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Experimental Medicine
Numberingvol. 169, no. 4, pp. 1199-1212
p-ISSN0022-1007
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.169.4.1199
URN:NBNurn:nbn:hr:184:885593
Publication1989-04-01
Document URLhttp://www.jem.org/cgi/doi/10.1084/jem.169.4.1199
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 3.0 Unported (CC BY 3.0) icon
Created on2019-02-27 19:07:20