prikaz prve stranice dokumenta The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening
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Scientific paper - Original scientific paper
The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening
Fetal Diagnosis and Therapy, 17 (2002), 1; 17-21. https://doi.org/10.1159/000047999
Tišlarić, Dubravka; Brajenović-Milić, Bojana; Ristić, Smiljana; Latin, Višnja; Žuvić-Butorac, Marta; Bačić, Josip; Petek, Marjan; Kapović, Miljenko

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Tišlarić, D., Brajenović Milić, B., Ristić, S., Latin, V., Žuvić Butorac, M., Bačić, J. ... Kapović, M. (2002). The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening. Fetal Diagnosis and Therapy, 17. (1), 17-21. doi: 10.1159/000047999

Tišlarić, Dubravka, et al. "The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening." Fetal Diagnosis and Therapy, vol. 17, no. 1, 2002, pp. 17-21. https://doi.org/10.1159/000047999

Tišlarić, Dubravka, Bojana Brajenović Milić, Smiljana Ristić, Višnja Latin, Marta Žuvić Butorac, Josip Bačić, Marjan Petek and Miljenko Kapović. "The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening." Fetal Diagnosis and Therapy 17, no. 1 (2002): 17-21. https://doi.org/10.1159/000047999

Tišlarić, D., et al. (2002) 'The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening', Fetal Diagnosis and Therapy, 17(1), pp. 17-21. doi: 10.1159/000047999

Tišlarić D, Brajenović Milić B, Ristić S, Latin V, Žuvić Butorac M, Bačić J, and sur.. The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening. Fetal Diagnosis and Therapy [Internet]. 2002 [cited 2024 April 26];17(1):17-21. doi: 10.1159/000047999

D. Tišlarić, et al., "The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening", Fetal Diagnosis and Therapy, vol. 17, no. 1, pp. 17-21, 2002. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:669692. [Accessed: 26 April 2024]

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Title (english)The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening The Influence of Smoking and Parity on Serum Markers for Down’s Syndrome Screening
AuthorDubravka Tišlarić
AuthorBojana Brajenović-Milić
AuthorSmiljana Ristić
AuthorVišnja Latin
AuthorMarta Žuvić-Butorac
AuthorJosip Bačić
AuthorMarjan Petek
AuthorMiljenko Kapović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
Objective: To evaluate the impact of smoking and number of previous births on maternal serum levels of α-fetoprotein and free β-subunit of human chorionic gonadotropin (free β-hCG). Methods: The study included 3,252 completed unaffected singleton pregnancies that proceeded beyond 37 weeks’ gestation and resulted with a birth of healthy child. Smoking status of mothers and data concerning gravidity and parity were collected at the sampling date. Serum markers were measured between 13 and 22 gestational weeks, corrected for maternal weight, and converted to multiples of median (MoM) for unaffected pregnancy of the corresponding gestational age. Median MoM values for both markers were examined in relation to both: smoking habits and number of previous births. Results: Smokers had significantly decreased free β-hCG MoM values compared to nonsmokers (p < 0.001). The median levels showed a negative relationship with the number of previous births. The significance of a decreasing trend was proved, both in smokers (p < 0.001) and nonsmokers (p < 0.001). The median maternal serum α-fetoprotein MoM values did not show any significant dependence, neither with regard to smoking (p = 0.65) nor with regard to parity (p = 0.07). Conclusions: The recommendable adjustment of serum markers to smoking habits, especially concerning the free β-hCG levels, would be worthwhile. The evidence of the coexisting influence of parity on serum levels of free β-hCG, both in smokers and nonsmokers, should perhaps be a stimulus for reconsideration of which corrections the screening performance is dependent on.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFetal Diagnosis and Therapy
Numberingvol. 17, no. 1, pp. 17-21
p-ISSN1015-3837
e-ISSN1421-9964
DOIhttps://doi.org/10.1159/000047999
URN:NBNurn:nbn:hr:184:669692
Publication2002
Document URLhttps://doi.org/10.1159/000047999
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2017-08-02 11:18:31